Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli

Blood Pressure

Volumn 18, Issue 5, 2009, Pages 286-293

  Mustonen, Erja ^a   Pohjolainen, Virva ^a   Aro, Jani ^a   Pikkarainen, Sampsa ^a   Leskinen, Hanna ^a   Ruskoaho, Heikki ^a   Rys, Jaana ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Cardiac remodeling; Extracellular matrix; Matrix Gla protein; Mechanical stretch; Pressure overload

Indexed keywords

ANGIOTENSIN II; ARGININE; BRAIN NATRIURETIC PEPTIDE; EARLY GROWTH RESPONSE FACTOR 1; ENDOTHELIN 1; MATRIX G1A PROTEIN; MATRIX PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; HEART INFARCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE HYPERTROPHY; HEART RATE; HEART VENTRICLE OVERLOAD; HEART VENTRICLE REMODELING; MALE; MEAN ARTERIAL PRESSURE; MECHANICAL STRESS; MUSCLE CELL; NEWBORN; NONHUMAN; OSMOTIC MINIPUMP; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRETCHING; UPREGULATION;

ANGIOTENSIN II; ANIMALS; ANIMALS, NEWBORN; ARGININE VASOPRESSIN; CALCIUM-BINDING PROTEINS; CELLS, CULTURED; ENDOTHELIN-1; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STRESS, MECHANICAL; UP-REGULATION;

EID: 70450172631     PISSN: 08037051     EISSN: 16511999     Source Type: Journal    
DOI: 10.1080/08037050903244643     Document Type: Article

References (50)

1. Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev. 1999;79:215-262.
2. Deschamps AM, S pinale FG. Matrix modulation and heart failure: New concepts question old beliefs. Curr Opin Cardiol. 2005;20:211-216.
3. Fedak PW, Verma S, Weisel RD, Li RK. Cardiac remodeling and failure From molecules to man (Part II). Cardiovasc Pathol. 2005;14:49-60. (Pubitemid 40381300)
4. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997;386:78-81.
5. Fraser JD, Price PA. Lung, heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla protein. Implications for the possible functions of matrix Gla protein and for the tissue distribution of the gamma-carboxylase. J Biol Chem. 1988;263:11033-11036.
6. Hale JE, F raser JD, Price PA. The identifi cation of matrix Gla protein in cartilage. J Biol Chem. 1988;263:5820-5824.
7. Owen TA, Aronow MS, B arone LM, B ettencourt B, S tein GS, Lian JB. Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: Dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures. Endocrinology. 1991;128:1496-1504.
8. Barone LM, Owen TA, Tassinari MS, B ortell R, S tein GS, Lian JB. Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis. J Cell Biochem. 1991;46:351-365.
9. Bostrom K, Z ebboudj AF, Y ao Y, Lin TS, Torres A. Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells. J Biol Chem. 2004;279:52904-52913.
10. Shanahan CM, W eissberg PL, M etcalfe JC. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Circ Res. 1993;73:193-204.
11. Cancela ML, Price PA. R etinoic acid induces matrix Gla protein gene expression in human cells. Endocrinology. 1992;130:102-108.
12. Shanahan CM, C ary NR, M etcalfe JC, W eissberg PL. H igh expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J Clin Invest. 1994;93:2393-2402.
13. Shanahan CM, Proudfoot D, Farzaneh-Far A, Weissberg PL. The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr. 1998;8:357-375.
14. Demer LL, Tintut Y. Mineral exploration: Search for the mechanism of vascular calcification and beyond: The 2003 Jeffrey M. Hoeg Award lecture. Arterioscler Thromb Vasc Biol. 2003;23:1739-1743.
15. Schurgers LJ, Cranenburg EC, V ermeer C. Matrix Gla-protein: The calcification inhibitor in need of vitamin K. Thromb Haemost. 2008;100:593-603.
16. Mirotsou M, Dzau VJ, P ratt RE, Weinberg EO. Physiological genomics of cardiac disease: Quantitative relationships between gene expression and left ventricular hypertrophy. Physiol Genomics. 2006;27:86-94.
17. Weinberg EO, M irotsou M, G annon J, D zau VJ, L ee RT, Pratt RE. Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload. Physiol Genomics. 2003;12:113-127.
18. Hwang DM, Dempsey AA, Lee CY, Liew CC. Identification of differentially expressed genes in cardiac hypertrophy by analysis of expressed sequence tags. Genomics. 2000;66:1-14.
19. Blaxall BC, S pang R, R ockman HA, K och WJ. Differential myocardial gene expression in the development and rescue of murine heart failure. Physiol Genomics. 2003;15:105-114.
20. Rysa J, L eskinen H, I lves M, R uskoaho H. D istinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure. Hypertension. 2005;45:927-933.
21. Nishimoto SK, Nishimoto M. Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development. Matrix Biol. 2005;24: 353-361.
22. Magga J, M arttila M, M antymaa P, V uolteenaho O, Ruskoaho H. Brain natriuretic peptide in plasma, atria, and ventricles of vasopressin- and phenylephrine-infused conscious rats. Endocrinology. 1994;134:2505-2515.
23. Romppanen H, P uhakka J, F oldes G, Szokodi II, Vuolteenaho O, Tokola H, et al. Endothelin-1-independent and angiotensin II-independent induction of adrenomedullin gene expression. Hypertension. 2001;37:84-90.
24. Rysa J, A ro J, R uskoaho H. E arly left ventricular gene expression profi le in response to increase in blood pressure. Blood Press. 2006;15:375-383.
25. Foldes G, Suo M, S zokodi I, L ako-Futo Z, d eChatel R, Vuolteenaho O, et al. Factors derived from adrenals are required for activation of cardiac gene expression in angiotensin IIinduced hypertension. Endocrinology. 2001;142:4256-4263.
26. Suo M, H autala N, F oldes G, S zokodi I, T oth M, Leskinen H, et al. Posttranscriptional control of BNP gene expression in angiotensin II-induced hypertension. Hypertension. 2002;39:803-808.
27. Tenhunen O, Soini Y, Ilves M, Rysa J, Tuukkanen J, Serpi R, et al. p38 Kinase rescues failing myocardium after myocardial infarction: Evidence for angiogenic and anti-apoptotic mechanisms. FASEB J. 2006;20:1907-1909.
28. Pikkarainen S, T okola H, K erkela R, I lves M, M akinen M, Orzechowski HD, et al. Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1639-R1645.
29. Pikkarainen S, Tokola H, Majalahti-Palviainen T, Kerkela R, Hautala N, Bhalla SS, et al. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. J Biol Chem. 2003;278:23807-23816.
30. van Wamel JE, Ruwhof C, van der Valk-Kokshoorn EJ, Schrier PI, van der Laarse A. Rapid gene transcription induced by stretch in cardiac myocytes and fibroblasts and their paracrine Influence on stationary myocytes and fibroblasts. Pflugers Arch. 2000;439:781-788.
31. Magga J, V uolteenaho O, T okola H, M arttila M, R uskoaho H. Involvement of transcriptional and posttranscriptional mechanisms in cardiac overload-induced increase of B-type natriuretic peptide gene expression. Circ Res. 1997;81:694-702.
32. Farzaneh-Far A, Weissberg PL, Proudfoot D, Shanahan CM. Transcriptional regulation of matrix Gla protein. Z Kardiol. 2001;90 Suppl 3 :38-42.
33. Bostrom KI. C ell differentiation in vascular calcification. Z Kardiol. 2000;89 Suppl 2 :69-74.
34. Sweatt A, Sane DC, Hutson SM, Wallin R. Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats. J Thromb Haemost. 2003; 1:178-185.
35. Murshed M, Schinke T, M cKee MD, Karsenty G. Extracellular matrix mineralization is regulated locally; Different roles of two gla-containing proteins. J Cell Biol. 2004;165: 625-630.
36. Proudfoot D, Shanahan CM. Molecular mechanisms mediating vascular calcification: Role of matrix Gla protein. Nephrology (Carlton). 2006;11:455-461.
37. Gilbert KA, R annels SR. Matrix Gla protein modulates branching morphogenesis in fetal rat lung. Am J Physiol Lung Cell Mol Physiol. 2004;286:L1179-L1187.
38. Villarreal FJ, Dillmann WH. Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen. Am J Physiol. 1992;262:H1861-H1866.
39. Hilfi ker-Kleiner D, Kaminski K, K aminska A, F uchs M, Klein G, Podewski E, et al. Regulation of proangiogenic factor CCN1 in cardiac muscle: Impact of ischemia, pressure overload, and neurohumoral activation. Circulation. 2004;109:2227-2233.
40. Shi-Wen X, L eask A, A braham D. R egulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 2008;19:133-144.
41. Mustonen E, Aro J, P uhakka J, Ilves M, Soini Y, Leskinen H, et al. Thrombospondin-4 expression is rapidly upregulated by cardiac overload. Biochem Biophys Res Commun. 2008; 373: 186-191.
42. Chapman D, Weber KT, Eghbali M. Regulation of fibrillar collagen types I and III and basement membrane type IV collagen gene expression in pressure overloaded rat myocardium. Circ Res. 1990;67:787-794. (Pubitemid 20315010)
43. Crawford DC, C hobanian AV, B recher P. Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat. Circ Res. 1994;74:727-739.
44. Mirotsou M, Dzau VJ, Pratt RE, Weinberg EO. Physiological genomics of cardiac disease: Quantitative relationships between gene expression and left ventricular hypertrophy. Physiol Genomics. 2006;27:86-94.
45. Kieffer P, R obert A, Capdeville-Atkinson C, Atkinson J, Lartaud-Idjouadiene I. Age-related arterial calcification in rats. Life Sci. 2000;66:2371-2381.
46. Pfeffer JM, P feffer MA, M irsky I, B raunwald E. R egression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acad Sci U S A. 1982;79:3310-3314.
47. Herrmann SM, W hatling C, B rand E, N icaud V, Gariepy J, Simon A, et al. Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction. Arterioscler Thromb Vasc Biol. 2000;20:2386-2393.
48. Gygi SP, R ochon Y, Franza BR, A ebersold R. C orrelation between protein and mRNA abundance in yeast. Mol Cell Biol. 1999;19:1720-1730.
49. Tuomisto TT, Riekkinen MS, Viita H, Levonen AL, Yla-Herttuala S. Analysis of gene and protein expression during monocyte-macrophage differentiation and cholesterol loading-cDNA and protein array study. Atherosclerosis. 2005;180:283-291.
50. Komuro I. Molecular mechanism of mechanical stress-induced cardiac hypertrophy. Jpn Heart J. 2000;41:117-129.