A role for protein ubiquitination in VEGFR-2 signalling and angiogenesis

Biochemical Society Transactions

Volumn 37, Issue 6, 2009, Pages 1189-1192

  Rahimi, Nader ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Endothelial cell; Phospholipase C 1 (PLC 1); Ubiquitination; Vascular endothelial growth factor receptor 2 (VEGFR 2)

Indexed keywords

CBL PROTEIN; PHOSPHOLIPASE C GAMMA1; UBIQUITIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; ENDOTHELIUM CELL; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ENDOTHELIAL CELLS; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOLIPASE C GAMMA; PROTO-ONCOGENE PROTEINS C-CBL; SIGNAL TRANSDUCTION; UBIQUITIN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTORS;

MUS;

EID: 70450163031     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0371189     Document Type: Article

References (20)

1. Hanahan, D. and Folkman, J. (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364
2. Rahimi, N. (2006) VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front. Biosci. 11, 818-829
3. Meyer, R.D., Sacks, D.B. and Rahimi, N. (2008) IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS ONE 3, e3848
4. Meyer, R.D., Latz, C. and Rahimi, N. (2003) Recruitment and activation of phospholipase Cγ 1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells. J. Biol. Chem. 278, 16347-16355
5. Takahashi, T., Yamaguchi, S., Chida, K. and Shibuya, M. (2001) A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLCγ and DNA synthesis in vascular endothelial cells. EMBO J. 20, 2768-2778
6. Griner, E.M. and Kazanietz, M.G. (2007) Protein kinase C and other diacylglycerol effectors in cancer. Nat. Rev. Cancer 7, 281-294
7. Pawson, T. and Nash, P. (2000) Protein-protein interactions define specificity in signal transduction. Genes Dev. 14, 1027-1047
8. Liao, H.J., Kume, T., McKay, C., Xu, M.J., Ihle, J.N. and Carpenter, G. (2002) Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J. Biol. Chem. 277, 9335-9341
9. Covassin, L.D., Siekmann, A.F., Kacergis, M.C., Laver, E., Moore, J.C., Villefranc, J.A., Weinstein, B.M. and Lawson, N.D. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Dev. Biol. 329, 212-226
10. Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. and Shibuya, M. (2005) Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl. Acad. Sci. U.S.A. 102, 1076-1081
11. Singh, A.J., Meyer, R.D., Navruzbekov, G., Shelke, R., Duan, L., Band, H., Leeman, S.E. and Rahimi, N. (2007) A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCγ 1 activation and angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 104, 5413-5418
12. Hochstrasser, M. (2009) Origin and function of ubiquitin-like proteins. Nature 458, 422-429
13. Ravid, T. and Hochstrasser, M. (2008) Diversity of degradation signals in the ubiquitin-proteasome system. Nat. Rev. Mol. Cell Biol. 9, 679-690
14. Schwartz, A.L. and Ciechanover, A. (2009) Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu. Rev. Pharmacol. Toxicol. 49, 73-79
15. Tonks, N.K. (2006) Protein tyrosine phosphatases: from genes, to function, to disease. Nat. Rev. Mol. Cell Biol. 7, 833-846
16. 292 negative regulatory phosphorylation site of ZAP-70. J. Biol. Chem. 272, 33140-33144
17. Singh, A.J., Meyer, R.D., Band, H. and Rahimi, N. (2005) The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol. Biol. Cell. 16, 2106-2118
18. Graham, L.J., DeBell, K.E, Veri, M., Stoica, B., Mostowski, H., Bonvini, E. and Rellahan, B. (2000) Differential effects of Cbl and 70Z/ 3 Cbl on T cell receptor-induced phospholipase C. 1 activity. FEBS Lett. 470, 273-280
19. Swaminathan, G. and Tsygankov, A.Y. (2006) The Cbl family proteins: ring leaders in regulation of cell signaling. J. Cell. Physiol. 209, 21-43
20. Murphy, M.A., Schnall, R.G., Venter, D.J., Barnett, L., Bertoncello, I., Thien, C.B., Langdon, W.Y. and Bowtell, D.D. (1998) Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol. Cell. Biol. 18, 4872-4882