Use of corticosteroids in critically ill septic patients: A review of mechanisms of adrenal insufficiency in sepsis and treatment

Current Drug Targets

Volumn 10, Issue 9, 2009, Pages 887-894

  Annetta, M G ^a   Maviglia, R ^a   Proietti, R ^a   Antonelli, M ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Adrenal insufficiency; CIRCI; Corticosteroids; Corticotropin test; Septic shock; Vasopressor

Indexed keywords

CORTICOSTEROID; CORTICOTROPIN; ETOMIDATE; FLUDROCORTISONE; GLUCOCORTICOID; HYDROCORTISONE; HYPERTENSIVE FACTOR; KETOCONAZOLE; METHYLPREDNISOLONE; METYRAPONE; PLACEBO; STEROID;

ADRENAL FUNCTION; ADRENAL INSUFFICIENCY; ANTIINFLAMMATORY ACTIVITY; CARDIOVASCULAR EFFECT; CLINICAL FEATURE; CLINICAL TRIAL; CONTINUOUS INFUSION; CORTICOTROPIN TEST; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; EVIDENCE BASED MEDICINE; FLUID RESUSCITATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERGLYCEMIA; HYPERNATREMIA; HYPOKALEMIA; HYPOTENSION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INSULIN TOLERANCE TEST; INTENSIVE CARE UNIT; LABORATORY TEST; LOW DRUG DOSE; MEDICAL DECISION MAKING; METABOLIC ACIDOSIS; MYOPATHY; NONHUMAN; PATHOGENESIS; PRACTICE GUIDELINE; PSYCHOSIS; REVIEW; SEPSIS; SEPTIC SHOCK; STEROIDOGENESIS; TREATMENT DURATION; WOUND HEALING IMPAIRMENT;

ADRENAL CORTEX HORMONES; ADRENAL INSUFFICIENCY; CRITICAL ILLNESS; HUMANS; SEPSIS;

EID: 70450162821     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945009789108792     Document Type: Review

References (51)

1. Parrillo JE. Septic shock-vasopressin, norepinephrine, and urgency. N Engl J Med 2008; 358(9): 954-956
2. Annane D. Improving trials in the critically ill: unique challenge - sepsis. Crit Care Med 2009; 37(1 Suppl): S117-28.
3. Maxime V, Lesur O, Annane D. Adrenal insufficiency in septic shock. Clin Chest Med 2009; 30(1): 17-27.
4. Annane D, Bellissant E. Prognostic value of cortisol response in septic shock. JAMA 2000; 284(3): 308-309
5. Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008; 36(6): 1937-1949
6. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign : International guidelines for management of severe sepsis and septic shock : 2008. Intensive Care Med 2008; 34(1): 17-60.
7. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, et al. Isolation and characterization of a novel APJ receptor. Biochem Biophys Res Commun 1998; 251(2): 471-476
8. Yaguchi H, Tsutsumi K, Shimono K, Omura M, Sasano H, Nishikawa T. Involvement of high density lipoprotein as substrate cholesterol for steroidogenesis by bovine adrenal fasciculo-reticularis cells. Life Sci 1998; 62(16): 1387-1395 (Pubitemid 28143981)
9. Albert SG, DeLeon MJ, Silverberg AB. Possible association between high-dose fluconazole and adrenal insufficiency in critically ill patients. Crit Care Med 2001; 29(3): 668-670 (Pubitemid 32225315)
10. Jacobi J. Corticosteroid replacement in critically ill patients. Crit Care Clin 2006; 22(2): 245-253
11. Ho JT, Al-Musalhi H, Chapman MJ, Quach T, Thomas PD, Bagley CJ, et al. Septic shock and sepsis : a comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab 2006; 91(1): 105-114 (Pubitemid 43069125)
12. Rogerson FM, Fuller PJ. Interdomain interactions in the mineralcorticoid receptor. Mol Cell Endocrinol 2003; 200: 45-55.
13. Cai TQ, Wong B, Mundt SS, Thieringer R, Wright SD, Hermanowski-Vosatka A. Induction of 11 beta-hydrossysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli. J Steroid Biochem Mol Biol 2001; 77: 117-122 (Pubitemid 32476819)
14. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N Engl J Med 2005; 353 : 1711-1723 (Pubitemid 41464710)
15. Galon J, Franchimont D, Hiroi N, Frey G, Boettner A, Ehrhart-Bornstein M, et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J 2002; 16: 61-71. (Pubitemid 34027951)
16. Gonzalez H, Nardi O, Annane D. Relative adrenal failure in the ICU: an identifiable problem requiring treatment. Crit Care Clin 2006; 22: 105-118. (Pubitemid 43037112)
17. Maxime V, Fitting C, Annane D, Cavaillon JM. Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock. J Infect Dis 2005; 191: 138-144 (Pubitemid 40041412)
18. Goldstein IM , Roos D, Weissmann G, Kaplan HB. Influence of corticosteroids on human polymorphonuclear leukocyte function in vitro. Inflammation 1976; 1: 305-315
19. Orlowski J, Lingrel JB. Thyroid and glucocorticoid hormones regulate the expression of multiple Na, K-ATPase genes in cultured neonatal rat cardiac myocytes. J Biol Chem 1990; 265: 3462-3470 (Pubitemid 20087338)
20. Prasongsukarn K, Abel JG, Jamieson WR, Cheung A, Russell JA, Walley KR, et al. The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery : a prospective randomized trial. J Thorac Cardiovasc Surg 2005; 130: 93-98. (Pubitemid 40941674)
21. Halonen J, Halonen P, Järvinen O, Taskinen P, Auvinen T, Tarkka M, et al. Corticosteroids for the prevention of atrial fibrillation after cardiac surgery : a randomized controlled trial. JAMA 2007; 297: 1562-1567 (Pubitemid 46588369)
22. Chappell D, Jacob M, Hofmann-Kiefer K, Bruegger D, Rehm M, Conzen P, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology 2007; 107: 776-784 (Pubitemid 351325970)
23. Bateman A, Singh A, Kral T, Solomon S. The immunehypothalamic-pituitary- adrenal axis. Endocr Rev 1989; 10: 92-112.
24. Soni A, Pepper GM, Wyrwinski PM, Ramirez NE, Simon R, Pina T, et al. Adrenal insufficiency occurring during septic shock : incidence, outcome, and relationship to peripheral cytokine levels. Am J Med 1995; 98: 266-271
25. Natarajan R, Ploszaj S, Horton R, Nadler J. Tumor necrosis factor and interleukin-1 are potent inhibits of angiotensin 2 induced aldosterone synthesis. Endocrinology 1989; 125: 3084-3089 (Pubitemid 20010686)
26. Sharshar T, Annane D, de la Grandmaison GL, Brouland JP, Hopkinson NS, Françoise G. The neuropathology of septic shock. Brain Pathol 2004; 14: 21-33.
27. Sharshar T, Gray F, de la Grandmaison GL, Hopkinson NS, Ross E, Dorandeu A, et al. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003; 362: 1799-1805. (Pubitemid 37494758)
28. Maxime V, Siami S, Annane D. Metabolism mediators in sepsis : the abnormal pituitary response. Crit Care Med 2007; 35: S596-S601. (Pubitemid 47312201)
29. Karanth S, Lyson K, McCann SM. Role of nitric oxide in interleukin-2 induced corticotropin releasing factor release from incubated hypothalami. Proc Natl Acad Sci USA 1993; 90: 3383-3387 (Pubitemid 23111370)
30. Chien JY, Jerng JS, Yu CJ, Yang PC. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med 2005; 33: 1688-1693 (Pubitemid 41153691)
31. van Leeuwen HJ, Heezius EC, Dallinga GM, van Strijp JA, Verhoef J, van Kessel KP. Lipoprotein metabolism in patients with severe sepsis. Crit Care Med 2003; 31: 1359-1366 (Pubitemid 36583844)
32. van der Voort PH, Gerritsen RT, Bakker AJ, Boerma EC, Kuiper MA, de Heide L. HDL-cholesterol level and cortisol response to synacthen in critically ill patients. Intensive Care Med 2003; 29: 2199-2203.
33. Prigent H, Maxime V, Annane D. Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit Care 2004; 8:243-252 (Pubitemid 39144714)
34. Marik PE, Zaloga GP. Adrenal insufficiency in the critically ill: a new look at an old problem. Chest 2002; 122: 1784-1796 (Pubitemid 35366095)
35. Annane D, Sébille V, Troché G, Raphaël JC, Gajdos P, Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283: 1038-1045 (Pubitemid 30112218)
36. Marik PE, Zaloga GP. Adrenal insufficiency during septic shock. Crit Care Med 2003; 31: 141-145
37. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisones on mortality in patients with septic shock. JAMA 2002; 288: 862-871 (Pubitemid 34898534)
38. Loisa P, Uusaro A, Ruokonen E. A single adrenocorticotropic hormone stimulation test does not reveal adrenal insufficiency in septic shock. Anesth Analg 2005; 101: 1792-1798 (Pubitemid 41720638)
39. Arafah BM. Hypothalamic-pituitary adrenal function during critical illness: limitations of current assessment methods. J Clin Endocrinol Metab 2006; 91: 3725-3745
40. Veterans Administration Systemic Sepsis Cooperative Study Group. Effect of high dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987; 317: 659-665
41. Lefering R, Neugebauer EA. Steroid controversy in sepsis and septic shock: a metaanalysis. Crit Care Med 1995; 23: 1294-1303.
42. El Azab SR, Rosseel PM, de Lange JJ, Groeneveld AB, van Strik R, van Wijk EM, et al. Dexamethasone decreases the pro and antiinflammatory cytokine ratio during cardiac surgery. Br J Aneasth 2002; 88: 496-501.
43. Marik PE. Critical illness-related corticosteroid insufficiency. Chest 2009; 135: 181-193
44. Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998; 26: 645-650 (Pubitemid 28201409)
45. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358: 111-124
46. Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev 2004; 1: CD002243.
47. Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis : results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007; 167: 1655-2163 (Pubitemid 47280347)
48. Lekkou A, Karakantza M, Mouzaki A, Kalfarentzos F, Gogos CA. Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diagn Lab Immunol 2004; 11: 161-167 (Pubitemid 38090671)
49. Annane D, Cavaillon JM. Corticosterids in sepsis : from bench to bedside? Shock 2003; 20: 197-207.
50. Kaufmann I, Briegel J, Schliephake F, Hoelzl A, Chouker A, Hummel T, et al. Stress doses of hydrocortisone in septic shock: beneficial effects on opsonization-dependent neutrophil function. Intensive Care Med 2008; 34: 344-349 (Pubitemid 351207639)
51. De Jonghe B, Lacherade JC, Durand MC, Sharshar T. Critical illness neuromuscular syndromes. Neurol Clin 2008; 26: 507-520