Rapid determination of losartan and losartan acid in human plasma by multiplexed LC-MS/MS

Journal of Separation Science

Volumn 32, Issue 20, 2009, Pages 3388-3394

  Shah, Hiten J ^a,b,c   Kundlik, Mohan L ^a   Patel, Nitesh K ^a   Subbaiah, Gunta ^a   Patel, Dasharath M ^b   Suhagia, Bhanubhai N ^c   Patel, Chhagan N ^b  

^a Torrent Pharmaceuticals Ltd   (India)

^b Shri Sarvajanik Pharmacy College   (India)

^c L M COLLEGE OF PHARMACY   (India)

Author keywords

Human plasma; Losartan; Losartan acid; Multiplexed LC MS MS; Negative ion electrospray

Indexed keywords

ANALYTES; CONCENTRATION RANGES; CORRELATION COEFFICIENT; HUMAN PLASMA SAMPLES; HUMAN PLASMAS; HYDROFLUMETHIAZIDE; INTERNAL STANDARDS; LC-MS/MS; LOSARTAN; MULTIPLEXING TECHNIQUES; NEGATIVE ION ELECTROSPRAY; PHARMACOKINETIC STUDIES; RAPID DETERMINATION; RUNTIMES; VALIDATED METHODS;

ACIDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MULTIPLEXING; NEGATIVE IONS; PLASMAS;

PLASMA (HUMAN);

HYDROFLUMETHIAZIDE; LOSARTAN; LOSARTAN ACID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NEGATIVE ION ELECTROSPRAY; NORMAL HUMAN; PRIORITY JOURNAL; QUALITY CONTROL; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ACIDS; ANTIHYPERTENSIVE AGENTS; CHROMATOGRAPHY, LIQUID; HUMANS; HYDROFLUMETHIAZIDE; IMIDAZOLES; LOSARTAN; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TETRAZOLES;

EID: 70450159931     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900287     Document Type: Article

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