Determination of plasma concentrations of losartan in patients by HPLC using solid phase extraction and UV detection

International Journal of Pharmaceutics

Volumn 204, Issue 1-2, 2000, Pages 17-22

  Yeung, Pollen K F ^a   Jamieson, Angela ^b   Smith, Gareth J ^b   Fice, Debbra ^b   Pollak, P Timothy ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NONE

Author keywords

EXP3174; HPLC; Losartan; Metabolism; Pharmacokinetics; Plasma

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ACETONITRILE; AMMONIUM DERIVATIVE; LOSARTAN POTASSIUM; METHANOL; SODIUM AZIDE;

ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; ENVIRONMENTAL TEMPERATURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; REPRODUCIBILITY; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION;

ANTIHYPERTENSIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMAN; HYPERTENSION; IMIDAZOLES; LOSARTAN; SUPPORT, NON-U.S. GOV'T; TETRAZOLES;

EID: 0034690944     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00453-1     Document Type: Article

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3. Fluconazole but not itraconazole decreases the metabolism of losartan to E-3174
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10. Comparison of liquid chromatography, capillary electrophoresis and super-critical fluid chromatography in the determination of losartan postassium drug substance in Cozaar tablets
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