HPLC assays to simultaneously determine the angiotensin-AT1 antagonist losartan as well as its main and active metabolite EXP 3174 in biological material of humans and rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 16, Issue 5, 1998, Pages 863-873

  Soldner, Andrea ^a   Spahn Langguth, Hildegard ^b   Mutschler, Ernst ^a  

^a GOETHE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Antagonists; Bile; Blood; EXP 3174; Losartan; Nonpeptide Angiotensin AT1; Plasma; Rats; Reversed phase high performance liquid chromatography; Solid phase extraction; Tissues; Urine

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN ANTAGONIST; LOSARTAN;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INTRAPERITONEAL DRUG ADMINISTRATION; LIQUID LIQUID EXTRACTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; STANDARD; VALIDATION PROCESS;

ANGIOTENSIN I; ANIMALS; ANTIHYPERTENSIVE AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMIDAZOLES; LOSARTAN; RATS; RECEPTORS, ANGIOTENSIN; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; TETRAZOLES; TISSUE DISTRIBUTION;

EID: 0031932550     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(97)00128-3     Document Type: Article

References (8)

1. Duncia J.V., Carini D.J., Chiu A.T., Johnson A.L., Price W.A., Wong P.C., Wexler R.R., Timmermans P.B.M.W.M. Med. Res. Rev. 12:1992;149-191.
2. Timmermans P.B.M.W.M., Wong P.C., Chiu A.T., Herblin W.F., Benfield P., Carini D.J., Lee R.J., Wexler R.R., Saye J.M., Smith R.D. Pharmacol. Rev. 45:1993;205-251.
3. Wong P.C., Price W.A., Chiu A.T., Duncia J.V., Carini D.J., Wexler R.R., Johnson A.L., Timmermans P.B.M.W.M. J. Pharm. Exp. Ther. 255:1990;211-217.
4. Stearns R.A., Miller R.R., Doss G.A., Chakravarty P.K., Rosegay A., Gatto G.J., Chiu S.H.-L. Drug Metab. Disp. 20:1992;281-287.
5. Stearns R.A., Chakravarty P.K., Chen R., Chiu S.H.-L. Drug Metab. Disp. 23:1995;207-215.
6. V.J. Dzau, Circulation 77, (Suppl. I) (1988) I4-I13.
7. Shah V.P., Midha K.K., Dighe S., McGilveray I.J., Skelly J.P., Yacobi A., Layloff T., Viswanathan C.T., Cook C.E., McDowall R.D., Pittman K.A., Spector S. Eur. J. Drug Metab. Pharmacokinet. 16(4):1991;249-255.
8. Furtek C.I., Lo M.-W. J. Chromatogr. Biomed. Appl. 573:1992;295-301.