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Volumn 21, Issue 3-4, 2009, Pages 316-323

Protein recognition via oligonucleotide-linked small molecules: Utilisation of the hemin-binding aptamer

Author keywords

Aptamers; DNA self assembly; DNAzyme; Protein recognition; Supramolecular chemistry

Indexed keywords


EID: 70449727984     PISSN: 10610278     EISSN: 10290478     Source Type: Journal    
DOI: 10.1080/10610270802549717     Document Type: Article
Times cited : (6)

References (43)
  • 10
    • 70449703051 scopus 로고    scopus 로고
    • ODN moiety is used to direct specific sequences of DNA-linked materials to appropriate columns (containing their complementary sequence) for subsequent selective synthetic transformations. Such an approach enables the conversion of genetic information into chemical functionality that can be used for subsequent target protein-binding
    • ODN moiety is used to direct specific sequences of DNA-linked materials to appropriate columns (containing their complementary sequence) for subsequent selective synthetic transformations. Such an approach enables the conversion of genetic information into chemical functionality that can be used for subsequent target protein-binding
  • 28
    • 33947599087 scopus 로고    scopus 로고
    • The majority of chemical alterations undertaken on aptamers have focused on modifying the core oligonucleotide sequence to improve their drug-like activity (i.e. enhancing nuclease resistance and/or primary target affinity)
    • Shlyahovsky, B.; Li, D.; Katz, E.; Willner, I. Biosens. Bioelectron. 2007, 22, 2570-2576. The majority of chemical alterations undertaken on aptamers have focused on modifying the core oligonucleotide sequence to improve their drug-like activity (i.e. enhancing nuclease resistance and/or primary target affinity)
    • (2007) Biosens. Bioelectron , vol.22 , pp. 2570-2576
    • Shlyahovsky, B.1    Li, D.2    Katz, E.3    Willner, I.4
  • 38
    • 70449724373 scopus 로고    scopus 로고
    • It should be noted that Willner and co-workers have elegantly demonstrated that the allosteric nature of the hemin-binding aptamer (when tethered to other nucleic acid sequences or proteins) can lead to bifunctional molecules capable of detecting various agents of import (including DNA, AMP, lysozyme and glucose)
    • It should be noted that Willner and co-workers have elegantly demonstrated that the allosteric nature of the hemin-binding aptamer (when tethered to other nucleic acid sequences or proteins) can lead to bifunctional molecules capable of detecting various agents of import (including DNA, AMP, lysozyme and glucose).
  • 41
    • 70449720339 scopus 로고    scopus 로고
    • In addition, Kolpashchikov has recently shown that an ODN containing the hemin-binding aptamer can be split into binary components that selfassemble in the presence of a specific DNA sequence and hence can be used as a probe for detecting single nucleotide polymorphism
    • In addition, Kolpashchikov has recently shown that an ODN containing the hemin-binding aptamer can be split into binary components that selfassemble in the presence of a specific DNA sequence and hence can be used as a probe for detecting single nucleotide polymorphism
  • 43
    • 70449714898 scopus 로고    scopus 로고
    • However, to the best of our knowledge, there has been no exploration of using the hemin-binding aptamer linked to a synthetic fragment for targeted protein-binding and detection
    • However, to the best of our knowledge, there has been no exploration of using the hemin-binding aptamer linked to a synthetic fragment for targeted protein-binding and detection.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.