A human domain antibody and lewis b glycoconjugate that inhibit binding of helicobacter pylori to lewis b receptor and adhesion to human gastric epithelium

Journal of Infectious Diseases

Volumn 200, Issue 10, 2009, Pages 1574-1582

  Younson, Justine ^a   OMahony, Rachel ^b,g   Liu, Haiqun ^c   Grant, Steven ^c   Campion, Colin ^d   Jennings, Lisa ^e   Vaira, Dino ^f   Kelly, Charles G ^a   Roitt, Ivan M ^b   Holton, John ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Domantis   (United Kingdom)

^d Carbohydrate Synthesis   (United Kingdom)

^e GE HEALTHCARE   (United Kingdom)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g Natl Inst for Clinical Excellence   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; ADHESIN BABA; BACTERIUM ANTIBODY; GLYCOCONJUGATE; HUMAN SERUM ALBUMIN; OLIGOSACCHARIDE; POLY DEXTRO LYSINE; UNCLASSIFIED DRUG; BABA PROTEIN, HELICOBACTER PYLORI;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BLOOD GROUP LEWIS SYSTEM; CONTROLLED STUDY; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; MICROBIAL ADHESION; NONHUMAN; PRIORITY JOURNAL; STOMACH EPITHELIUM; STOMACH SECRETION; SURFACE PLASMON RESONANCE; HELICOBACTER INFECTION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; IN VITRO STUDY; MICROBIOLOGY; PASSIVE IMMUNIZATION; STOMACH; STOMACH MUCOSA;

ADHESINS, BACTERIAL; ANTIBODY SPECIFICITY; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN VARIABLE REGION; LEWIS BLOOD-GROUP SYSTEM; STOMACH;

EID: 70449719619     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/644596     Document Type: Article

References (26)

1. Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. Helicobacter pylori virulence and genetic geography. Science 1999; 284: 1328-1333
2. Ilver D, Arnqvist A. Ogren J, et al. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 1998; 279:373-377
3. Gerhard M, Lehn N, Neumayer N, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci USA 1999; 96:12778-12783
4. Olfat FO, Zheng Q, Oleastro M, et al Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. FEMS Immunol Med Microbiol 2005; 44:151-156
5. Guruge JL, Falk PG, Lorenz RG, et al. Epithelial attachment alters the outcome of Helicobacter pylori infection. Proc Natl Acad Sci USA 1998; 95:3925-3930
6. Mahdavi J, Sonden B, Hurtig M, et al Helicobacter pylori SabA adhesinin persistent infection and chronic inflammation. Science 2002; 297: 573-578
7. Bytzer P, OMorain C. Treatment of Helicobacter pylori. Helicobacter 2005; 10(Suppl 1):40-46
8. Koletzko S, Richy F, Bontems P, et al. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 2006; 55:1711-1716
9. Stromqvist M, Falk P, Bergstrom S, et al. Human milk kappa-casein and inhibition of Helicobacter pylori adhesion to human gastricmucosa. J Pediatr Gastroenterol Nutr 1995; 21:288-296
10. Clyne M, Thomas J, Weaver L, Drumm B. In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells. Gut 1997; 40:731-738
11. Gustafsson A, Hultberg A, Sjostrom R, et al. Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine milk. Glycobiology 2006; 16:1-10.
12. Ward ES, Güssow D, Griffiths AD, Jones PT, Winter G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 1989; 341:544-546 (Pubitemid 19252529) (Pubitemid 19252529)
13. Holt LJ, Herring C, Jespers LS, Woolven BP, Tomlinson IM. Domain antibodies: proteins for therapy. Trends Biotechnol 2003; 21:484-490
14. Holliger P, Hudson PJ. Engineered antibody fragments and the rise of single domains. Nat Biotechnol 2005; 23:1126-1135 (Pubitemid 41486394) (Pubitemid 41486394)
15. Bovin NV, Khorlin AY. Synthesis of determinant oligosaccharides of the ABH (type 1) blood group antigen and Leb tetrasaccharide from a common precursor. Bioorganicheskaia Khimiia 1984; 10:853-860
16. Dekany G, Wright K, Toth I. An economical synthesis of Lewis X, sialyl Lewis X and their a-galactosyl analogues. J Carbohydrate Chemistry 1997; 16:983-999 (Pubitemid 127358571)
17. Johnson KJ, Hawkins RE. Affinity maturation of antibodies using phage display. In: McCafferty J, Hoogenboom H, Chiswell D, eds. Antibody engineering, a practical guide. Oxford, United Kingdom: Oxford University Press, 1995:41-58.
18. OMahoney R, Basset C, Holton J, Vaira D, Roitt I. Comparison of image analysis software packages in the assessment of adhesion of micro-organisms to mucosal epithelium using confocal laser scanning microscopy. J Microbiol Methods 2005; 61:105-126 (Pubitemid 40164880) (Pubitemid 40164880)
19. Holton J, Yiu CY, Vaira D. Adhesins of Helicobacter pylori. In: Ed Anand R, Smith P, Warne P. Emerging therapeutic targets. London: Ashley Publications, 1997:21-23
20. De Bernadis F, Liu H, OMahony R, et al. Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. J Infect Dis 2007; 195:149-157
21. Pai JC, Sutherland JN, Maynard JA. Progress toward recombinant antiinfective antibodies. Recent Pat Antiinfect Drug Discov 2009; 4:1-17.
22. Ruprecht RM. Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in Macaque models: experimental approaches. Methods Mol Biol 2009; 525:1-8.
23. Schneemann A, Manchester M. Anti-toxin antibodies in prophylaxis and treatment of inhaled anthrax. Future Microbiol 2009; 4:35-43.
24. Aspholm-Hurtig M, Dailide G, Lahmann M, et al. Functional adaptation of Bab A, the H. pylori ABO blood group antigen binding adhesin. Science 2004; 305:519-522
25. Pant N, Hultberg A, Zhao Y, et al. Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea. J Infect Dis 2006; 194: 1580-1588 (Pubitemid 44851901)
26. Rojo J, Diaz V, de la Fuente JM, et al. Gold glyconanoparticles as new tools in antiadhesive therapy. Chembiochem 2004; 5:291-297 (Pubitemid 39257122) (Pubitemid 39257122)