The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a chinese population

Liver International

Volumn 29, Issue 9, 2009, Pages 1383-1388

  Cao, Bangwei ^a   Liu, Xing ^b   Hou, Fang ^a   Li, Wende ^c   Han, Zhonggang ^c   Zhang, Qipeng ^c   Dai, Yue ^a   Xu, Changqing ^d   Qi, Huimin ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Haplotype; Hepatitis virus B; MxA gene; Promoter; Susceptibility

Indexed keywords

ADENINE; CYTOSINE; DNA; GUANINE; MYXOVIRUS RESISTANCE PROTEIN A; THYMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MYXOVIRUS RESISTANCE PROTEINS;

ADULT; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HAPLOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INFECTION SENSITIVITY; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VIRUS RESISTANCE; GENETICS; MIDDLE AGED;

ADULT; CASE-CONTROL STUDIES; FEMALE; GTP-BINDING PROTEINS; HAPLOTYPES; HEPATITIS B; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC;

EID: 70449715733     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02053.x     Document Type: Article

References (25)

1. Custer B, Sullivan SD, Hazlet TK, et al. Global epidemiology of hepatitis B virus. J Clin Gastroenterol 2004; 38: S158-68.
2. Shi M, Qian S, Chen WW, et al. Hepatitis B virus (HBV) antigen-pulsed monocyte-derived dendritic cells from HBV-associated hepatocellular carcinoma patients significantly enhance specific T cell responses in vitro. Clin Exp Immunol 2007; 147: 277-86.
3. Ganem D, Prince A.M. Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 2004; 350: 1118-29.
4. Chu CM, Liaw Y.F. Natural history of chronic hepatitis B virus infection: an immunopathological study. J Gastroenterol Hepatol 1997; 12: S218-22.
5. Gish R.G. Improving outcomes for patients with chronic hepatitis B. Curr Gastroenterol Rep 2007; 9: 14-22.
6. Cao B, Yang H, Ding H, et al. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population. Clin Chem Lab Med 2007; 45: 333-8.
7. Liu M, Cao B, Zhang H, et al. Association of interferongamma gene haplotype in the Chinese population with hepatitis B virus infection. Immunogenetics 2006; 58: 859-64.
8. Carroll TD, Matzinger SR, Genesca M, et al. Interferoninduced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication. J Immunol 2008; 180: 2385-95.
9. Kong XF, Zhang XX, Gong QM, et al. MxA induction may predict sustained virologic responses of chronic hepatitis B patients with IFN-alpha treatment. J Interferon Cytokine Res 2007; 27: 809-18.
10. Oelschlegel R, Kruger DH, Rang A. MxA-independent inhibition of Hantaan virus replication induced by type I and type II interferon in vitro. Virus Res 2007; 127: 100-5.
11. Torisu H, Kusuhara K, Kira R, et al. Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. Neurology 2004; 62: 457-60.
12. Holzinger D, Jorns C, Stertz S, et al. Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J Virol 2007; 81: 7776-85.
13. Knapp S, Yee LJ, Frodsham AJ, et al. Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and P.K.R. Genes Immun 2003; 4: 411-9.
14. He J, Feng D, de Vlas SJ, et al. Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study. BMC Infect Dis 2006; 6: 106.
15. Xu C, Qi S, Gao L, et al. Genetic polymorphisms of LMP/ TAP gene and hepatitis B virus infection risk in the Chinese population. J Clin Immunol 2007; 27: 534-41.
16. Bahr MJ, el Menuawy M, Boeker KH, et al. Cytokine gene polymorphisms and the susceptibility to liver cirrhosis in patients with chronic hepatitis C. Liver Int 2003; 23: 420-5.
17. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162-9.
18. Seeger C, Mason W.S. Hepatitis B virus biology. Microbiol Mol Biol Rev 2000; 64: 51-68.
19. Guo H, Jiang D, Zhou T, et al. Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation. J Virol 2007; 81: 12472-84.
20. Gordien E, Rosmorduc O, Peltekian C, et al. Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein. J Virol 2001; 75: 2684-91.
21. Horisberger M.A. Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins. J Virol 1992; 66: 4705-9.
22. Reichelt M, Stertz S, Krijnse-Locker J, et al. Missorting of LaCrosse virus nucleocapsid protein by the interferoninduced MxA GTPase involves smooth ER membranes. Traffic 2004; 5: 772-84.
23. Hijikata M, Mishiro S, Miyamoto C, et al. Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites ((123 and (88) in vivo and in vitro. Intervirology 2001; 44: 379-82.
24. Peng XM, Lei RX, Gu L, et al. Influences of MxA gene (88 G/T and IFN-gamma 1874 A/T on the natural history of hepatitis B virus infection in an endemic area. Int J Immunogenet 2007; 34: 341-6.
25. Kao J.H. Appropriate use of interferon for treatment of chronic hepatitis B. Hepatol Res 2007; 37: S47-54.