Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent cryptosporidium infections in young children

Journal of Infectious Diseases

Volumn 200, Issue 10, 2009, Pages 1540-1547

  Carmolli, Marya ^a   Dugga, Priya ^b   Haque, Rashidul ^d   Lindow, Janet ^a   Mondal, Dinesh ^d   Petri Jr , William A ^c   Mourningstar, Phoenix ^a   Larsson, Catherine J ^a   Sreenivasan, Meera ^a   Khan, Salwa ^a   Kirkpatrick, B D ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

Author keywords

[No Author keywords available]

Indexed keywords

MANNOSE BINDING LECTIN; MANNOSE BINDING LECTIN 2; PLASMA PROTEIN; MBL2 PROTEIN, HUMAN;

ALLELE; AMEBIASIS; ARTICLE; BANGLADESH; CHILD; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM; DNA POLYMORPHISM; ENTAMOEBA HISTOLYTICA; FEMALE; FOLLOW UP; GIARDIA LAMBLIA; GIARDIASIS; HAPLOTYPE; HUMAN; INFECTION RISK; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; RECURRENT INFECTION; ANIMAL; GENETICS; IMMUNOLOGY; PROMOTER REGION; PROSPECTIVE STUDY; RISK; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SPOROZOITE;

ANIMALS; CHILD; CHILD, PRESCHOOL; CRYPTOSPORIDIOSIS; FEMALE; HAPLOTYPES; HUMANS; IMMUNITY, INNATE; MALE; MANNOSE-BINDING LECTIN; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; RISK FACTORS; SPOROZOITES;

EID: 70449708038     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/606013     Document Type: Article

References (41)

1. Turner MW. The role of mannose-binding lectin in health and disease. Mol Immunol 2003; 40:423-429 (Pubitemid 37244035) (Pubitemid 37244035)
2. Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003; 37:1496-1505 (Pubitemid 37494678) (Pubitemid 37494678)
3. Cambi A, Koopman M, Figdor CG. How C-type lectins detect pathogens. Cell Microbiol 2005; 7:481-488 (Pubitemid 40439447) (Pubitemid 40439447)
4. Miller ME. A familial, plasma-associated defect of phagocytosis: a new cause of recurrent bacterial infections. Lancet 1968; 292:60-63
5. Super M, Thiel S, Lu J, Levinsky RJ, Turner MW. Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet 1989; 2:1236-1239 (Pubitemid 19284122)
6. Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 2000; 68: 688-693 (Pubitemid 30056524) (Pubitemid 30056524)
7. Capparelli R, Iannaccone M, Palumbo D, et al. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. J Infect Dis 2009; 199:666-672
8. Kelly P, Jack DL, Naeem A, et al. Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. Gastroenterology 2000; 119:1236-1242
9. Ezekowitz RA. Role of the mannose-binding lectin in innate immunity. J Infect Dis 2003; 187:S335-9.
10. Super M, Ezekowitz RA. The role of mannose-binding proteins in host defense. Infect Agents Dis 1992; 1:194-199
11. Turner MW. Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today 1996; 17:532-540
12. Garred P, Larsen F, Madsen HO, Koch C. Mannose-binding lectin deficiency-revisited. Mol Immunol 2003; 40:73-84.
13. Ohlenschlaeger T, Garred P, Madsen HO, Jacobsen S. Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus. N Engl J Med 2004; 351:260-267 (Pubitemid 38916043) (Pubitemid 38916043)
14. Eisen DP, Dean MM, Boermeester MA, et al. Low serum mannosebinding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis 2008; 47:510-516
15. Fidler KJ, Wilson P, Davies JC, Turner MW, Peters MJ, Klein NJ. Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin. Intensive Care Med 2004; 30:1438-1445 (Pubitemid 38951729)
16. Rantala A, Lajunen T, Juvonen R, et al. Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men. J Infect Dis 2008; 198:1247-1253
17. Kirkpatrick BD, Huston CD, Wagner D, et al. Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. Clin Infect Dis 2006; 43:289-294 (Pubitemid 44078898) (Pubitemid 44078898)
18. Casanova JL, Abel L. Human mannose-binding lectin in immunity: friend, foe, or both? J Exp Med 2004; 199:1295-1299 (Pubitemid 38685721) (Pubitemid 38685721)
19. Garred P, Larsen F, Seyfarth J, Fujita R, Madsen HO. Mannose-binding lectin and its genetic variants. Genes Immun 2006; 7:85-94. (Pubitemid 43336050) (Pubitemid 43336050)
20. Madsen HO, Satz ML, Hogh B, Svejgaard A, Garred P. Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol 1998; 161:3169-3175 (Pubitemid 28425746)
21. Juliger S, Luckner D, Mordmuller B, et al. Promoter variants of the human mannose-binding lectin gene show different binding. Biochem Biophys Res Commun 2000; 275:617-622 (Pubitemid 30682924) (Pubitemid 30682924)
22. Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. BMJ 1997; 314:1229-1232 (Pubitemid 27173906)
23. Hilgendorff A, Heidinger K, Pfeiffer A, et al. Association of polymorphisms in the mannose-binding lectin gene and pulmonary morbidity in preterm infants. Genes Immun 2007; 8:671-677 (Pubitemid 350238437) (Pubitemid 350238437)
24. Koch A, Melbye M, Sorensen P, et al. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 2001; 285:1316-1321 (Pubitemid 32216146)
25. Thorarinsdottir HK, Ludviksson BR, Vikingsdottir T, et al. Childhood levels of immunoglobulins and mannan-binding lectin in relation to infections and allergy. Scand J Immunol 2005; 61:466-474 (Pubitemid 40695018) (Pubitemid 40695018)
26. Hibberd ML, Sumiya M, Summerfield JA, Booy R, Levin M. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Meningococcal Research Group. Lancet 1999; 353:1049-1053 (Pubitemid 29149913) (Pubitemid 29149913)
27. Luty AJ, Kun JF, Kremsner PG. Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. J Infect Dis 1998; 178:1221-1224
28. Lima AA, Moore SR, Barboza MS Jr, et al. Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil. J Infect Dis 2000; 181:1643-1651
29. Newman RD, Sears CL, Moore SR, et al. Longitudinal study of Cryptosporidium infection in children in northeastern Brazil. J Infect Dis 1999; 180:167-175
30. Haque R, Duggal P, Ali IM, et al. Innate and acquired resistance toamebiasis in Bangladeshi children. J Infect Dis 2002; 186:547-552 (Pubitemid 34876265) (Pubitemid 34876265)
31. Rossignol JF, Ayoub A, Ayers MS. Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of nitazoxanide. J Infect Dis 2001; 184:103-106 (Pubitemid 32568508)
32. Haque R, Mondal D, Kirkpatrick BD, et al. Epidemiologic and clinical characteristics of acute diarrhea with emphasis on Entamoeba histolytica infections in preschool children in an urban slum of Dhaka, Bangladesh. Am J Trop Med Hyg 2003; 69:398-405.
33. Steffensen R, Thiel S, Varming K, Jersild C, Jensenius JC. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods 2000; 241:33-42. (Pubitemid 30468508) (Pubitemid 30468508)
34. Alagarasu K, Selvaraj P, Swaminathan S, Raghavan S, Narendran G, Narayanan PR. Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India. Tuberculosis (Edinb) 2007; 87:535-543 (Pubitemid 47589041) (Pubitemid 47589041)
35. Catano G, Agan BK, Kulkarni H, et al. Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations. J Infect Dis 2008; 198:72-80. (Pubitemid 351920292) (Pubitemid 351920292)
36. Thio CL, Mosbruger T, Astemborski J, et al. Mannose binding lectin genotypes influence recovery from hepatitis B virus infection. J Virol 2005; 79:9192-9196 (Pubitemid 40934830) (Pubitemid 40934830)
37. Naito H, Ikeda A, Hasegawa K, et al. Characterization of human serum mannan-binding protein promoter. J Biochem 1999; 126:1004-1012 (Pubitemid 30014445)
38. Arnold JN, Dwek RA, Rudd PM, Sim RB. Mannan binding lectin and its interaction with immunoglobulins in health and in disease. Immunol Lett 2006; 106:103-110
39. Jack DL, Read RC, Tenner AJ, Frosch M, Turner MW, Klein NJ. Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. J Infect Dis 2001; 184:1152-1162
40. Agnew DG, Lima AA, Newman RD, et al. Cryptosporidiosis in northeastern Brazilian children: association with increased diarrhea morbidity. J Infect Dis 1998; 177:754-760
41. Kirkpatrick BD, Daniels MM, Jean SS, et al. Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children. J Infect Dis 2002; 186:94-101.