Low dose nitrite enhances perfusion after fluid resuscitation from hemorrhagic shock

Resuscitation

Volumn 80, Issue 12, 2009, Pages 1431-1436

  Cabrales, Pedro ^a  

^a LA JOLLA BIOENGINEERING INSTITUTE   (United States)

Author keywords

Functional capillary density; Hemorrhage; Microcirculation; Nitric oxide; Perfusion; Reperfusion

Indexed keywords

HETASTARCH; METHEMOGLOBIN; OXYHEMOGLOBIN; SODIUM NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CAPILLARY DENSITY; CONTROLLED STUDY; FLUID RESUSCITATION; HEART RATE; HEMODYNAMICS; HEMORRHAGIC SHOCK; HYPOVOLEMIC SHOCK; ISCHEMIA; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; SYRIAN HAMSTER; VASCULAR RESISTANCE; VASOCONSTRICTION; VENOUS RETURN;

ANALYSIS OF VARIANCE; ANIMALS; CRICETINAE; FLUID THERAPY; HEMODYNAMICS; HETASTARCH; MALE; MICROCIRCULATION; SHOCK, HEMORRHAGIC; SODIUM NITRITE;

EID: 70449697916     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2009.09.005     Document Type: Article

References (34)

1. Cabrales P., Intaglietta M., and Tsai A.G. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation 75 (2007) 124-134
2. Cabrales P., Tsai A.G., and Intaglietta M. Exogenous nitric oxide induces protection during hemorrhagic shock. Resuscitation (2009)
3. Tsai A.G., and Intaglietta M. The unusual properties of effective blood substitutes. Keio J Med 51 (2002) 17-20
4. Salazar Vazquez B.Y., Wettstein R., Cabrales P., et al. Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation. Biochim Biophys Acta 1784 (2008) 1421-1427
5. Lundvall J., and Gustafsson D. Impairment during marked hypotension of the plasma volume control in hemorrhage. Acta Physiol Scand 114 (1982) 371-378
6. Colantuoni A., Bertuglia S., and Intaglietta M. Quantitation of rhythmic diameter changes in arterial microcirculation. Am J Physiol 246 (1984) H508-H517
7. Endrich B., Asaishi K., Götz A., and Messmer K. Technical report: a new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med 177 (1980) 125-134
8. Tsai A.G., Friesenecker B., McCarthy M., et al. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am J Physiol 275 (1998) H2170-H2180
9. Cabrales P., Tsai A.G., Frangos J.A., and Intaglietta M. Role of endothelial nitric oxide in microvascular oxygen delivery and consumption. Free Radic Biol Med 39 (2005) 1229-1237
10. Winterbourn C.C. Reaction of superoxide with hemoglobin. CRC handbook of methods for oxygen radical research. 1st ed. (1985), CRC Press, Boca Raton, FL p. 137-41
11. Cabrales P., Tsai A.G., and Intaglietta M. Microvascular pressure and functional capillary density in extreme hemodilution with low and high plasma viscosity expanders. Am J Physiol 287 (2004) H363-H373
12. Tsai A.G., Cabrales P., Winslow R.M., and Intaglietta M. Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia. Am J Physiol Heart Circ Physiol 285 (2003) H1537-H1545
13. Intaglietta M., Silverman N.R., and Tompkins W.R. Capillary flow velocity measurements in vivo and in situ by television methods. Microvasc Res 10 (1975) 165-179
14. Lipowsky H.H., and Zweifach B.W. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res 15 (1978) 93-101
15. Intaglietta M., and Tompkins W.R. Microvascular measurements by video image shearing and splitting. Microvasc Res 5 (1973) 309-312
16. Lundberg J.O., and Weitzberg E. NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol 25 (2005) 915-922
17. Kugler P., and Drenckhahn D. Intrinsic source of stomach NO. Nature 370 (1994) 25-26
18. Cosby K., Partovi K.S., Crawford J.H., et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9 (2003) 1498-1505
19. Kozlov A.V., Staniek K., and Nohl H. Nitrite reductase activity is a novel function of mammalian mitochondria. FEBS Lett 454 (1999) 127-130
20. Zhang Z., Naughton D.P., Blake D.R., et al. Human xanthine oxidase converts nitrite ions into nitric oxide (NO). Biochem Soc Trans 25 (1997) 524S
21. Groner W., Winkelman J.W., Harris A.G., et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 5 (1999) 1209-1212
22. Slaaf D.W., Tangelder G.J., Reneman R.S., et al. A versatile incident illuminator for intravital microscopy. Int J Microcirc Clin Exp 6 (1987) 391-397
23. Ince C. The microcirculation is the motor of sepsis. Crit Care 9 Suppl. 4 (2005) S13-S19
24. De Backer D., Creteur J., Preiser J.C., et al. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 166 (2002) 98-104
25. De Backer D., Creteur J., Dubois M.J., et al. Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 147 (2004) 91-99
26. Spronk P.E., Ince C., Gardien M.J., et al. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 360 (2002) 1395-1396
27. Dejam A., Hunter C.J., Tremonti C., et al. Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation 116 (2007) 1821-1831
28. Lundberg J.O., Weitzberg E., and Gladwin M.T. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7 (2008) 156-167
29. Bennett B.M., McDonald B.J., Nigam R., and Simon W.C. Biotransformation of organic nitrates and vascular smooth muscle cell function. Trends Pharmacol Sci 15 (1994) 245-249
30. McGuire J.J., Anderson D.J., and Bennett B.M. Inhibition of the biotransformation and pharmacological actions of glyceryl trinitrate by the flavoprotein inhibitor, diphenyleneiodonium sulfate. J Pharmacol Exp Ther 271 (1994) 708-714
31. Maragos C.M., Morley D., Wink D.A., et al. Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 34 (1991) 3242-3247
32. Md S., Moochhala S.M., and Siew-Yang K.L. The role of inducible nitric oxide synthase inhibitor on the arteriolar hyporesponsiveness in hemorrhagic-shocked rats. Life Sci 73 (2003) 1825-1834
33. Thiemermann C., Szabo C., Mitchell J.A., and Vane J.R. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci USA 90 (1993) 267-271
34. Cabrales P., Tsai A.G., and Intaglietta M. Is resuscitation from hemorrhagic shock limited by blood oxygen-carrying capacity or blood viscosity?. Shock 27 (2007) 380-389