Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPARγ and PI3K

Journal of Ethnopharmacology

Volumn 126, Issue 3, 2009, Pages 533-537

  Kumar, Ramadhar ^a   Balaji, S ^a   Uma, T S ^a   Sehgal, P K ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

Fruit extracts; Glucose transporter (Glut 4); L6 myotubes; Momordica charantia (MC); Peroxisome proliferator activator receptor gamma (PPAR ); Phosphotidylinositol 3 kinase (PI3K)

Indexed keywords

ANTIDIABETIC AGENT; CHLOROFORM; CYCLOHEXIMIDE; GLUCOSE TRANSPORTER 4; INSULIN; MESSENGER RNA; MOMORDICA CHARANTIA EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; ROSIGLITAZONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ETHNOPHARMACOLOGY; FRUIT; GENE EXPRESSION REGULATION; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; MYOBLAST; MYOTUBE; NONHUMAN; PROTEIN SYNTHESIS; RAT; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; MOMORDICA CHARANTIA; PLANT EXTRACTS; PPAR GAMMA; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

MOMORDICA CHARANTIA;

EID: 70449687888     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.08.048     Document Type: Article

References (36)

1. Anandharajan R., Pathmanathan K., Shankernarayanan N.P., Viswakarma R.A., and Balakrishnan A. Upregulation of Glut-4 and PPARγ by an isoflavone from Pterocarpus marsupium on L6 myotubes: a possible mechanism of action. Journal of Ethnopharmacology 97 (2005) 253-260
2. Bandyopadhyay G., Standaert M.L., Galloway L., Moscat J., and Farese R.V. Evidence for involvement of protein kinase C (PKC)-z and non-involvement of diacylglycerolsensitive PKCs in insulin-stimulated glucose transport in L6 myotubules. Endocrinology 138 (1997) 4721-4731
3. Ben W.C., Roffey A., Atwal S., Timothy J., and Stan K. Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3 L1 adipose cells. Journal of Ethnopharmacology 112 (2007) 77-84
4. Brain K.R., and Turner T.D. The Practical Evaluation of Phytopharmaceuticals. 2nd ed. (1975), Bristol Wright Sciencetechnica pp. 81-82
5. Buhl E.S., Jessen N., Schmitz O., Steen B., Pedersen S.B., Pedersen O., Holman G.D., and Lund S. Chronic treatment with 5-aminoimidazole-4 carboxamide-1-b-D-ribofuranoside increases insulin-stimulated glucose uptake and GLUT-4 translocation in rat skeletal muscles in a fiber type-specific manner. Diabetes 50 (2001) 12-17
6. Ciaraldi T.P., Huber-Khudsen K., Hickman M., and Olefsky J.M. Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents. Metabolism 44 (1995) 976-981
7. Chuang C.Y., Hsu C., Chao C.Y., Wein Y.S., Kuo Y.H., and Huang C.J. Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARalpha in bitter gourd (Momordica charantia L.). Journal of Biomedical Science 13 (2006) 763-772
8. Desvergne B., and Wahli W. Peroxisome proliferatoractivated receptors: nuclear control of metabolism. Endocrine Reviews 20 (1999) 649-688
9. Evans W.C. Trease and Evans' Pharmacognosy. 14th ed. (1996), W.B. Sounders Company Limited, London, England 545-546
10. Grover J.K., and Yadav S.P. Pharmacological actions and potential uses of Momordica charantia: a review. Journal of Ethnopharmacology 93 (2004) 123-132
11. Hall L.R., Mehlotra R.K., Higgins A.W., Haxhiu M.A., and Pearlman E. An essential role for interleukin-5 and eosinophils in helminth-induced airway hyper-responsiveness. Infection and Immunity 66 (1998) 4425-4430
12. Kausch C., Kru tzfeldt J., Witke A., Rettig A., Bachmann O., Rett K., Matthaei S., Machicao F., Ha ring H.U., and Stumvoll M. Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochemical and Biophysical Research Communications 280 (2001) 664-674
13. Kellerer M., Lammers R., and Haring H.U. Insulin signal transduction: possible mechanism for insulin resistance. Experimental and Clinical Endocrinology & Diabetes 107 (1999) 97-106
14. Khanna P., Jain S.C., Panagariya A., and Dixit V.P. Hypoglycaemic activity of polypeptide-p from a plant source. Journal of Natural Products 44 (1981) 648-655
15. Koivisto U.M., Martinez-Valdez H., Bilan P.J., Burdett E., Ramlal T., and Klip A. Differential regulation of the GLUT1 and GLUT4 glucose transport systems by glucose and insulin in L6 muscle cells in culture. Journal of Biological Chemistry 266 (1991) 615-2621
16. Laville M., Auboeuf D., Khalfallah Y., Vega N., Riou J.P., and Vidal H. Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle. Journal of Clinical Investigation 98 (1996) 43-49
17. Lotlikar M.M., and Rajarama R. Pharmacology of a hypoglycemic principle isolated from the fruits of Momordica charantia. Indian Journal of Pharmacy 28 (1966) 129-133
18. Mosman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65 (1983) 55-63
19. Mukherjee P.K., Maiti K., Mukherjee K., and Houghton P.J. Leads from Indian medicinal plants with hypoglycemic potentials. Journal of Ethnopharmacology 106 (2006) 1-28
20. Ntambi J.M., and Young Cheul K. Adipocyte differentiation and gene expression. The Journal of Nutrition 130 (2000) 3122S-3126S
21. Okada T., Kawano T., Sakakibara T., Hazeki O., and Ui M. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and anti-lipolysis in rat adipocytes-studies with a selective inhibitor wortmannin. Journal of Biological Chemistry 269 (1994) 3568-3573
22. Petersen K.F., Krssak M., Inzucchi S., Cline G.W., Dufour S., and Shulman G.I. Mechanism of troglitazone action in type 2 diabetes. Diabetes 49 (2000) 827-831
23. Rathi S., Grover J.K., and Vats V. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytotherapy Research 16 (2002) 236-243
24. Sahni S.K., Turpin L.C., Brown T.L., and Sporn L.A. Involvement of protein kinase C in Rickettsia rickettsii induced transcriptional activation of the host endothelial cell. Infection and Immunity 67 (1999) 6418-6423
25. Shimaya A., Kurosaki E., Shioduka K., Nakano R., Shibasaki M., and Shikama H. YM268 increases the glucose uptake, cell differentiation, and mRNA expression of glucose transporter in 3T3-L1 adipocytes. Hormone and Metabolic Research 30 (1998) 543-548
26. Singh J., Hundal H.S., Wackerhage H., Hope M., Belle M., Cummings E., and Adeghate E. Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes. Molecular and Cellular Biochemistry 216 (2004) 1-6
27. Sitasawad S., Shewade Y., and Bhonde R. Role of bittergourd fruit juice in STZ induced diabetic state in vivo and in vitro. Journal of Ethnopharmacology 73 (2000) 71-79
28. Suba V., Murugesan T., Arunachalam G., Mandal S.C., and Saha B.P. Anti-diabetic potential of Barleria lupulina extract in rats. Phytomedicine 11 (2004) 202-205
29. Taylor L. Technical data report for bitter melon (Momordica charantia). Herbal Secrets of the Rainforest. 2nd ed. (2002), Sage Press Inc. pp. 1-103
30. Tsakiridis T., McDowell H.E., Walker T., Downes C.P., Hundal H.S., Vranic M., and Klip A. Multiple roles of phosphatidlyionosital 3 kinase in regulation of glucose transport, aminoacid transport and glucose transporters in L6 skeletal muscle cells. Endocrinology 136 (1995) 4315-4322
31. Virdi J., Sivakami S., Shahani S., Suthar A.C., Banavlaikar M.M., and Biyani M.K. Antihyperglycemic effects of three extracts from Momordica charantia. Journal of Ethnopharmacology 88 (2003) 107-111
32. Venkatesh S., Reddy G.D., Reddy B.M., Ramesh M., and Appa Rao A.V.N. Antihyperglycemic activity of Caralluma attenuata. Fitoterapia 74 (2003) 274-279
33. Welihinda J., and Karunanayake E.H. Extra-pancreatic effects of Momordica charantia in rats. Journal of Ethnopharmacology 17 (1986) 247-255
34. Yasui Y., Hosokawa M., Sahara T., Suzuki R., Ohgiya S., Kohno H., Tanaka T., and Miyashita K. Bitter gourd seed fatty acid rich in 9c, 11t, 13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 73 (2005) 113-119
35. Yonemitsu S., Nishimura H., Shintani M., Inoue R., Yamamoto Y., Masuzaki H., Ogawa Y., Hosoda K., Inoue G., Hayashi T., and Nakao K. Troglitazone induces GLUT4 translocation in L6 myotubes. Diabetes 50 (2001) 1093-1101
36. Ziel F.H., Venkatesan N., and Davidson M.B. Glucose transport is rate limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes 37 (1988) 885-890