The influence of platelet-rich plasma on angiogenesis during the early phase of tendon healing

Foot and Ankle International

Volumn 30, Issue 11, 2009, Pages 1101-1106

  Lyras, Dimitrios N ^a   Kazakos, Konstantinos ^a   Verettas, Dionysios ^a   Polychronidis, Alekos ^a   Tryfonidis, Marios ^a   Botaitis, Sotirios ^a   Agrogiannis, George ^a   Simopoulos, Constantinos ^a   Kokka, Anna ^a   Patsouris, Efstratios ^a  

^a NONE

Author keywords

Growth factors; Platelet rich plasma; Rabbits; Tendon healing

Indexed keywords

CD31 ANTIGEN; COLLAGEN FIBER; HEMATOXYLIN; MONOCLONAL ANTIBODY; SODIUM CHLORIDE;

ACHILLES TENDON; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; FEMALE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROSCOPY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RABBIT; TENDON; TENDON INJURY; THROMBOCYTE RICH PLASMA; TISSUE REPAIR;

ACHILLES TENDON; ANIMALS; BIOMECHANICS; COLLAGEN; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PHYSIOLOGIC; PLATELET-RICH PLASMA; RABBITS; RUPTURE; TENDON INJURIES; WOUND HEALING;

EID: 70449629968     PISSN: 10711007     EISSN: None     Source Type: Journal    
DOI: 10.3113/FAI.2009.1101     Document Type: Article

References (31)

1. Amiel, D; Akeson, W; Harwood, FL; Frank, CB: Stress deprivation effect on metabolic turnover of medial collateral ligament collagen. A comparison between nine- and 12-week immobilization. Clin Orthop. 172:265-270, 1983.
2. Anitua, E: Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. J Oral Implantol. 14:529-535, 1999.
3. Anitua, E; Sánchez, M; Nurden, AT; et al.: Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A. 77(2):285-293, 2006. http://dx.doi.org/10. 1002/jbm.a.30585 (Pubitemid 47233530)
4. Aspenberg, P; Virchenko, O: Platelet concentrate injection improves Achilles tendon repair in rats Acta Orthop Scand. 75(1):93-99, 2004. http://dx.doi.org/10.1080/00016470410001708190
5. Bhatia, A; Nanda, S; Gupta, U; Gupta, S; Reddy, BS: Topical phenytoin suspension and normal saline in the treatment of leprosy trophic ulcers: a randomized, double-blind, comparative study. J Dermatolog Treat. 15(5):321-327, 2004. http://dx.doi.org/10.1080/ 09546630410018085
6. Chan, BP; Chan, KM; Maffulli, N;Webb, S; Lee, KK: Effect of basic fibroblast growth factor. An in vitro study of tendon healing. Clin Orthop Relat Res. 342:239-247, 1997. http://dx.doi.org/10.1097/00003086- 199709000-00031
7. Chan, BP; Fu, S; Qin, L; et al.: Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: a rat patellar tendon model. Acta Orthopaedica Scandinavica. 71:513-518, 2000. http://dx.doi.org/10.1080/ 000164700317381234
8. De Mos, M; van der Windt, AE; Jahr, H; et al.: Can platelet-rich plasma enhance tendon repair? A cell culture study. Am J Sports Med. 36(6):1171-1178, 2008. http://dx.doi.org/10.1177/0363546508314430
9. DelRossi, AJ; Cernaianu, AC; Vertrees, RA; et al.: Platelet-rich plasma reduces postoperative blood loss after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 100(2):281-286, 1990.
10. Fenwick, SA; Hazleman, BL; Riley, GP: The vasculature and its role in the damaged and healing tendon. Arthritis Res. 4:252-260, 2002. http://dx.doi.org/10.1186/ar416
11. Fernandez, R; Griffiths, R: Water for wound cleansing. Cochrane Database Syst Rev. 23(1):CD003861, 2008.
12. Ferrara, N: Vascular endothelial growth factor: Basic science and clinical progress. Endocr Rev. 25:581-611, 2004. http://dx.doi.org/10.1210/ er.2003-0027 (Pubitemid 39099316)
13. Ferrara, N; Davis-Smyth, T: The biology of vascular endothelial growth factor. Endocr Rev. 18:4-25, 1997. http://dx.doi.org/10.1210/ er.18.1.4 (Pubitemid 27076453)
14. Fox, SB; Leek, RD; Weekes, MP; et al.: Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis. J Pathol. 177:275-283, 1995. http://dx.doi.org/10.1002/path.1711770310
15. Hee, HT; Majd, ME; Holt, RT; Myers, L: Do autologous growth factors enhance transforaminal lumbar interbody fusion? Eur Spine J. 12(4):400-407, 2003. http://dx.doi.org/10.1007/s00586-003-0548-5
16. Hildebrand, KA; Woo, SL-Y; Smith, DW; et al.: The Effects of Platelet-Derived Growth Factor-BB on Healing of the Rabbit Medial Collateral Ligament. An In Vivo Study. Am J Sports Med. 26(4):549-554, 1998.
17. Ju, YJ; Tohyama, H; Kondo, E; et al.: Effects of Local Administration of Vascular Endothelial Growth Factor on Properties of the in Situ Frozen-Thawed Anterior Cruciate Ligament in Rabbits. Am J Sports Med. 34(1):84-91, 2006. http://dx.doi.org/10.1177/0363546505278700
18. Kazakos, K; Lyras, DN; Verettas, D; Tilkeridis, K; Tryfonidis, M: The use of autologous platelet-rich plasma gel as an aid in the management of acute trauma wounds. Injury 2008 [Epub ahead of print] PMID: 18703188.
19. Lyras, D; Kazakos, K; Verettas, D; et al.: Immunohistochemical study of angiogenesis after local administration of platelet-rich plasma in a patellar tendon defect. Int Orthop 2009 [Epub ahead of print] PMID: 19205700.
20. Maffulli, N; Moller, HD; Evans, CH: Tendon healing: can it be optimised? Growth factors may be useful in tendon healing, possibly introduced using gene therapy. Br J Sports Med. 36:315-316, 2002. http://dx.doi.org/10.1136/bjsm.36.5. 315
21. Margolis, DJ; Kantor, J; Santanna, J; Strom, BL; Berlin, JA: Effectiveness of platelet releasate for the treatment of diabetic neuropathic foot ulcers. Diabetes Care. 24:483-488, 2001. http://dx.doi.org/10.2337/diacare. 24.3.483 (Pubitemid 32198417)
22. Marx, RE: Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 10:225-228, 2001.
23. Molloy, T; Wang, Y; Murrell, G: The roles of growth factors in tendon and ligament healing. Sports Med. 33:381-394, 2003. http://dx.doi.org/10.2165/ 00007256-200333050-00004 (Pubitemid 36560710)
24. Petersen, W; Pufe, T; Unterhauser, F; et al.: The splice variants 120 and 164 of the angiogenic peptide vascular endothelial cell growth factor (VEGF) are expressed during Achilles tendon healing. Arch Orthop Trauma Surg. 123:475-480, 2003. http://dx.doi.org/10.1007/s00402-003- 0490-3
25. Petersen, W; Unterhauser, F; Pufe, T; et al.: The angiogenic peptide vascular endothelial growth factor (VEGF) is expressed during the remodeling of free tendon grafts in sheep. Arch Orthop Trauma Surg. 123:168-174, 2003. (Pubitemid 36747764)
26. Pierce, GF; Mustoe, TA; Altrock, BW; Deuel, TF; Thomason, A: Role of platelet-derived growth factor in wound healing. J Cell Biochem. 45:319-326, 1991. http://dx.doi.org/10.1002/jcb.240450403
27. Pufe, T; Petersen,WJ; Mentlein, R; Tillmann, BN: The role of vasculature and angiogenesis for the pathogenesis of degenerative tendons disease. Scand J Med Sci Sports. 15:211-222, 2005. http://dx.doi. org/10.1111/j.1600-0838.2005. 00465.x (Pubitemid 41032385)
28. Sánchez, M; Anitua, E; Azofra, J; et al.: Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 35(20):245-251, 2007. (Pubitemid 46145405)
29. Soffer, E; Ouhayoun, JP; Anagnostou, F: Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95:521-528, 2003. http://dx.doi.org/10.1067/moe.2003.152
30. Welsh, WJ: Autologous platelet gel-clinical function and usage in plastic surgery. Cosmetic Derm. 13:13-18, 2000.
31. Whitman, DH; Berry, RL; Green, DM: Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 55:1294-9, 1997. http://dx.doi.org/10.1016/S0278- 2391(97)90187-90197