Topical phenytoin suspension and normal saline in the treatment of leprosy trophic ulcers: A randomized, double-blind, comparative study

Journal of Dermatological Treatment

Volumn 15, Issue 5, 2004, Pages 321-327

  Bhatia, Ashima ^a,b   Nanda, S ^a   Gupta, U ^a   Gupta, S ^a   Reddy, B S N ^a  

^a MAULANA AZAD MEDICAL COLLEGE   (India)

^b SFS DDA Flats   (India)

Author keywords

Healing; Leprosy; Normal saline; Phenytoin; Trophic ulcers

Indexed keywords

PHENYTOIN; SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GINGIVA HYPERPLASIA; GRANULATION TISSUE; HUMAN; LEPROSY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SUSPENSION; TROPHIC ULCER; ULCER HEALING;

ACUTE DISEASE; ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LEPROSY; MALE; MIDDLE AGED; PHENYTOIN; SKIN ULCER; SODIUM CHLORIDE; SUSPENSIONS; WOUND HEALING;

EID: 7044226373     PISSN: 09546634     EISSN: None     Source Type: Journal    
DOI: 10.1080/09546630410018085     Document Type: Article

References (22)

1. Dharmendra, ed. Leprosy. Kothari: Bombay, 1978.
2. Bansal NK, Mukul, Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy. Int J Dermatol (1993) 32: 210-13.
3. Geater JG, The accurate measurement and recording of plantar ulcers. Lepr Rev (1978) 46: 195-8.
4. Bogaert H, Saleta B, Sanchez E, Garcia B, Trophic leprosy ulcers: treatment with topical and systemic phenytoin. Int J Dermatol (1990) 29: 156-7.
5. Shapiro M, Acceleration of gingival wound healing in nonepileptic patients receiving diphenylhydantoin sodium. Excerpta Med Surg (1958) 167: 41-53.
6. Pendse AK, Sharma A, Sodani A, Handa S, Topical phenytoin in wound healing. Int J Dermatol (1993) 32: 214-17.
7. El Zayat SG, Preliminary experience with topical phenytoin in wound healing in a war zone. Mil Med (1989) 154: 178-80.
8. Muthukumarasamy MG, Sivakumar G, Manoharan G, Topical phenytoin in diabetic foot ulcers. Diabetes Care (1991) 14: 909-11.
9. Smith BH, Moore M, Jain K, Report on the first international conference on the Uses of Phenytoin in Dermatology. Int J Dermatol (1988) 27: 528-30.
10. Lodha SC, Lohiya ML, Vyas MC et al, The role of phenytoin in the healing of large abscess cavities. Br J Surg (1991) 78: 105-8.
11. Smith BH, Bogoch S, Dreyfus J, eds. The broad range of clinical use of phenytoin. Bioelectrical modulator. Bibliography and review. Dreyfus Medical Foundation: New York, 1988.
12. Rodrigeuz-Noriega E, Esparza-Ahumda S, Andrade-Perez JS et al, Treatment of soft tissue ulcerations with topical diphenylhydantoinate. Invest Med Int (1983) 10: 184-6.
13. Malhotra YK, Amin SS, The role of topical phenytoin in trophic ulcers of leprosy in India. Int J Lepr (1991) 59: 337-8.
14. Modaghegh S, Salehian B, Tavassoli M et al, Use of phenytoin in healing of war and non-war wounds. A pilot study of 25 cases. Int J Dermatol (1989) 28: 347-50.
15. Mandiola-Gonzalez JF, Espejo-Plscencia I, Chapa-Alvarez JR, Rodriguez-Noriega E, Sodium diphenylhydantoin in burns: effects on pain and healing, Invest Med Int (1983) 10: 449-51.
16. Shirk MB, Phenytoin: wound healing. Micromedex (1992-1995) 77.
17. Thomas AC, Wysocki AB, The healing wound: a comparison of three clinically useful methods of measurement. Decubitus (1990) 3: 18-25.
18. Genever PG, Cunliffe WJ, Wood EJ, Influence of the extracellular matrix on flbroblast responsiveness to phenytoin using in vitro wound healing methods. Br J Dermatol (1995) 133: 231-5.
19. Matsuo A, Yajima T, Cell proliferation and collagen flbrogenesis of cultured flbroblasts. Jpn J Oral Bio/ (1985) 27: 56-63.
20. Shafer WG, Response of radiated human gingival fibroblast-like cells to Dilantin sodium in tissue culture. J Dent Res (1965) 44: 671-7.
21. Moy LS, Tan EML, Holness R, Uitto J, Phenytoin modulates connective tissue metabolism and cell proliferation in human skin flbroblast cultures. Arch Dermatol (1985) 121: 79-83.
22. Kasai S, Hachamine K, Effect of diphenylhydantoin sodium on the synthesis of collagen by some flbroblastic cell lines including gingival derived cell lines. Bull Tokyo Dent Coll (1974) 15: 53-62.