The effects of antipsychotics on brain structure: What have we learnt from structural imaging of schizophrenia?

Psychological Medicine

Volumn 39, Issue 11, 2009, Pages 1781-1782

  Borgwardt, S J ^a,b,c   Smieskova, R ^a,b   Fusar Poli, P ^c   Bendfeldt, K ^b   Riecher Rossler A ^a  

^a Psychiatric Outpatient Department   (Slovakia)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antipsychotics; ARMS; Brain structure; MRI; Schizophrenia

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE;

BRAIN SIZE; DRUG EFFECT; GRAY MATTER; HUMAN; IMAGE ANALYSIS; NEUROIMAGING; NONHUMAN; NOTE; RISK BENEFIT ANALYSIS; SCHIZOPHRENIA;

ANTIPSYCHOTIC AGENTS; BASAL GANGLIA; BRAIN; FRONTAL LOBE; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE IMAGING; ORGAN SIZE; PSYCHOTIC DISORDERS; REFERENCE VALUES; SCHIZOPHRENIA; TEMPORAL LOBE; THALAMUS;

EID: 70449627599     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291709006060     Document Type: Note

References (10)

1. Borgwardt SJ, McGuire PK, Aston J, Gschwandtner U, Pfluger MO, Stieglitz RD, Radue EW, Riecher-Rossler A (2008). Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophrenia Research 106, 108-114.
2. DeLisi LE (2008). Reviewing the 'facts about schizophrenia': a possible or impossible task? Schizophrenia Research 102, 19-20.
3. Fusar-Poli P, Perez J, Broome M, Borgwardt S, Placentino A, Caverzasi E, Cortesi M, Veggiotti P, Politi P, Barale F, McGuire P (2007). Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 31, 465-484.
4. Job DE, Whalley HC, Johnstone EC, Lawrie SM (2005). Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage 25, 1023-1030.
5. Konopaske GT, Dorph-Petersen KA, Sweet RA, Pierri JN, Zhang W, Sampson AR, Lewis DA (2008). Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biological Psychiatry 63, 759-765.
6. Navari S, Dazzan P (2009). Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychological Medicine. Published online: 2 April 2009. doi:10.1017/S0033291709005315.
7. Pantelis C, Velakoulis D, McGorry PD, Wood SJ, Suckling J, Phillips LJ, Yung AR, Bullmore ET, Brewer W, Soulsby B, Desmond P, McGuire PK (2003). Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361, 281-288.
8. Riecher-Rossler A, Gschwandtner U, Aston J, Borgwardt S, Drewe M, Fuhr P, Pfluger M, Radu W, Schindler C, Stieglitz RD (2007). The Basel early-detection-of-psychosis (FEPSY) study-design and preliminary results. Acta Psychiatrica Scandinavica 115, 114-125.
9. Smieskova R, Fusar-Poli P, Allen P, Bendfeldt K, Stieglitz RD, Drewe J, Radu EW, McGuire PK, Riecher A, Borgwardt SJ (in press). The effects of antipsychotics on the brain: What have we learnt from structural neuroimaging of schizophrenia?-a systematic review. Current Pharmaceutical Design.
10. Wood SJ, Pantelis C, Velakoulis D, Yucel M, Fornito A, McGorry PD (2008). Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophrenia Bulletin 34, 322-329.