Molecular dynamics simulations to investigate the relationship between the structural stability and amyloidogenesis of the wild-type and N-terminal hexapeptide deletion N6 2-microglobulin

Molecular Simulation

Volumn 35, Issue 9, 2009, Pages 755-765

  Fang, Po Sheng ^a   Zhao, Jian Hua ^a   Liu, Hsuan Liang ^a   Liu, Kung Tien ^b   Chen, Jenn Tzong ^b   Tsai, Wei Bor ^c   Lin, Hsin Yi ^a   Fang, Hsu Wei ^a   Ho, Yih ^d  

^a NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY   (Taiwan)

^b INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

2 microglobulin; N6 2m; Amyloidogenic intermediate; Dialysis related amyloidosis; K3 peptide; Molecular dynamics simulations

Indexed keywords

AMYLOID FIBRIL; AMYLOID FORMATION; AMYLOIDOGENESIS; AMYLOIDOGENIC INTERMEDIATE; CONFORMATIONAL CHANGE; DIALYSIS-RELATED AMYLOIDOSIS; EX-VIVO; FIBRIL MORPHOLOGY; HAEMODIALYSIS; INITIATION SITES; INTERACTION BETWEEN RESIDUES; K3 PEPTIDE; MOLECULAR DYNAMICS SIMULATIONS; N-TERMINALS; NEUTRAL PH; SELF-ASSOCIATIONS; SOLVENT EXPOSURE; STRUCTURAL STABILITIES; WATER MOLECULE; WILD TYPES;

ASSOCIATION REACTIONS; CONFORMATIONS; DIALYSIS; DYNAMICS; GLYCOPROTEINS; MOLECULAR DYNAMICS; MOLECULES; PEPTIDES; SALT REMOVAL; STABILITY;

AMINES;

EID: 70449587148     PISSN: 08927022     EISSN: 10290435     Source Type: Journal    
DOI: 10.1080/08927020902818005     Document Type: Article

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