Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples

Tetrahedron

Volumn 65, Issue 51, 2009, Pages 10535-10543

  Fang, Zhenglai ^a   Agoston, Gregory E ^b   Ladouceur, Gaetan ^b   Treston, Anthony M ^b   Wang, LiQuan ^c   Cushman, Mark ^a,d  

^a PURDUE UNIVERSITY   (United States)

^b ENTREMED INC   (United States)

^c XENOBIOTIC LABORATORIES INC   (United States)

^d Purdue University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; 6 HYDROXY 2 METHOXY 13 METHYL 6,8,9,11,12,13,14,15,16,17 DECAHYDRO 7H 20 OXACYCLOPROPA[16,17]CYCLOPENTA[A]PHENANTHRENE 3 CARBOXYLIC ACID AMIDE; 6 HYDROXY 2 METHOXY 13 METHYL 7,8,9,11,12,13,14,15 OCTAHYDRO 6H CYCLOPENTA[A]PHENANTHRENE 3 CARBOXAMIDE; ANTINEOPLASTIC AGENT; DNA; DRUG METABOLITE; ENMD 1198; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; DNA SYNTHESIS; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPOXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROXYLATION; IC 50; MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

EID: 70449572348     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.10.046     Document Type: Article

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