Engineering protein stability and specificity using fluorous amino acids: The importance of packing effects

Biochemistry

Volumn 48, Issue 45, 2009, Pages 10810-10817

  Buer, Benjamin C ^a   De La Salud Bea, Roberto ^a   Al Hashimi, Hashim M ^a   Marsh, E Neil G ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROUS; FOLDED PROTEINS; HELIX BUNDLE; HYDROPHOBIC AMINO ACIDS; HYDROPHOBIC CORE; PACKING EFFECTS; PHYSICOCHEMICAL PROPERTY; PROTEIN STABILITY; SIDE CHAINS; STABILIZING EFFECTS; THERMODYNAMICALLY STABLE;

AMINATION; AMINES; HYDROPHOBICITY; ORGANIC ACIDS; PROTEINS;

AMINO ACIDS;

ALPHA4 INTEGRIN; AMINO ACID; FLUOROCARBON; FLUOROUS AMINO ACID; LEUCINE; LEVO 5,5,5,5',5',5' HEXAFLUOROLEUCINE; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; ENZYME SPECIFICITY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACIDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN ENGINEERING; PROTEINS; THERMODYNAMICS;

EID: 70449562250     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901481k     Document Type: Article

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