How Cα-fluoroalkyl amino acids and peptides interact with enzymes: Studies concerning the influence on proteolytic stability, enzymatic resolution and peptide coupling

Current Topics in Medicinal Chemistry

Volumn 6, Issue 14, 2006, Pages 1483-1498

  Smits, René ^a   Koksch, Beate ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

C fluorinated amino acids; Enzymatic resolution; Fluorine; Non natural amino acids; Peptide coupling; Peptide design; Protein engineering; Proteolytic stability

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; ALANINE DERIVATIVE; ALKYL GROUP; AMIDASE; AMIDE; AMINO ACID DERIVATIVE; ANOREXIGENIC AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTILIPEMIC AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARBON; CARBOXYPEPTIDASE C; CHYMOTRYPSIN A; CLOSTRIPAIN; DIPEPTIDE DERIVATIVE; ENZYME INHIBITOR; ESTERASE; FLUORINE; PAPAIN; PEPTIDE DERIVATIVE; PHENYLALANINE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTIRELIN; PROTIRELIN DERIVATIVE; SUBTILISIN; TRYPSIN; UNINDEXED DRUG;

AMINO ACID SUBSTITUTION; CATALYSIS; CHEMICAL BOND; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC DEGRADATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; FLUORINATION; HORMONE INHIBITION; HUMAN; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SPECTROSCOPY; STRUCTURE ANALYSIS;

AMINO ACIDS; DRUG INTERACTIONS; ENZYME STABILITY; ENZYMES; FLUORINE; HYDROCARBONS, FLUORINATED; MOLECULAR STRUCTURE; PEPTIDES; PROTEIN ENGINEERING;

EID: 33746593245     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802606777951055     Document Type: Review

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