Preoperative statin treatment reduces systemic inflammatory response and myocardial damage in cardiac surgery

European Journal of Cardio-thoracic Surgery

Volumn 36, Issue 6, 2009, Pages 998-1005

  Martínez Comendador, José Manuel ^a   Alvarez, José Rubio ^a   Mosquera, Ignacio ^b   Sierra, Juan ^a   Adrio, Belén ^a   Carro, Javier G ^a   Fernández, Angel ^a   Bengochea, José ^a  

^a University Hospital of Santiago de Compostela   (Spain)

^b HOSPITAL JUAN CANALEJO   (Spain)

Author keywords

Extracorporeal circulation; Inflammation; Statins

Indexed keywords

ATORVASTATIN; CREATINE KINASE; CREATINE KINASE MB; HEPARIN; HEPARINA ROVI; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MEVINOLIN; PRAVASTATIN; SIMVASTATIN; TROPONIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY SURGERY; CREATINE KINASE BLOOD LEVEL; FEMALE; HEART MUSCLE INJURY; HEART SURGERY; HEART VALVE SURGERY; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

AGED; BIOLOGICAL MARKERS; BLOOD SPECIMEN COLLECTION; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEART VALVES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MIDDLE AGED; POSTOPERATIVE CARE; PREANESTHETIC MEDICATION; PROSPECTIVE STUDIES; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 70449528639     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2009.05.022     Document Type: Article

References (24)

1. Pritisanac A., Gulbins H., Rosendahl U., and Ennker J. Outcome of heart surgery procedures in octogenarians: is age really not an issue?. Expert Rev Cardiovasc Ther 5 (2007) 243-250 [review]
2. Murphy G.J., and Angelini G.D. Side effects of cardiopulmonary bypass: what is the reality?. J Card Surg 19 (2004) 481-488 [review]
3. Halter J., Steinberg J., Fink G., Lutz C., Picone A., Maybury R., Fedors N., DiRocco J., Lee H.M., and Nieman G. Evidence of systemic cytokine release in patients undergoing cardiopulmonary bypass. J Extra Corpor Technol 37 (2005) 272-277
4. Millar A.B., Armstrong L., van der Linden J., Moat N., Ekroth R., Westwick J., Scallan M., and Lincoln C. Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass. Ann Thorac Surg 56 (1993) 1499-1502
5. Sander M., von Heymann C., von Dossow V., Spaethe C., Konertz W.F., Jain U., and Spies C.D. Increased interleukin-6 after cardiac surgery predicts infection. Anesth Analg 102 June (6) (2006) 1623-1629
6. Schwartz G.G., Olsson A.G., Ezekowitz M.D., Ganz P., Oliver M.F., Waters D., Zeither A., Chaitman B.R., Leslie S., and Stern T. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. The MIRACL study: a randomized controlled trial. J Am Med Assoc 285 (2001) 1711-1718
7. Simes R.J., Marschner I.C., Hunt D., Colquhoun D., Sullivan D., Stewart R.A., Hague W., Keech A., Thompson P., White H., Shaw J., and Tonkin A. Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Trial. To what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels?. Circulation 105 (2002) 1162-1169
8. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360 (2002) 7-22
9. Wenke K., Meiser B., Thiery J., Nagel D., von Scheidt W., Steinbeck G., Seidel D., and Reichart B. Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial. Circulation 96 (1997) 1398-1402
10. Davignon J. Beneficial cardiovascular pleiotropic effects of statins. Circulation 109 Suppl. III (2004) III39-III43
11. Clark L.L., Ikonomidis J.S., Crawford Jr. F.A., Crumbley III A., Kratz J.M., and Stroud M.R. Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery. an 8-year retrospective cohort study. J Thorac Cardiovasc Surg 131 (2006) 679-685
12. Collard C.D., Body S.C., Shernan S.K., Wang S., Mangano D.T., Multicenter Study of Perioperative Ischemia (MCSPI) Research Group Inc.; Ischemia Research, and Education Foundation (IREF) Investigators. Preoperative statin therapy is associated with reduced cardiac mortality after coronary artery bypass graft surgery. J Thorac Cardiovasc Surg 132 (2006) 392-400
13. Fedoruk L.M., Wang H., Conaway M.R., Kron I.L., and Johnston K.C. Statin therapy improves outcomes after valvular heart surgery. Ann Thorac Surg 85 May (5) (2008) 1521-1525 [discussion 1525-6]
14. Virani S.S., Nambi V., Lee V.V., Elayda M., Reul R.M., Wilson J.M., and Ballantyne C.M. Does preoperative statin therapy improve outcomes in patients undergoing isolated cardiac valve surgery?. Am J Cardiol 102 9 (2008) 1235-1239
15. Chello M., Patti G., Candura D., Mastrobuoni S., Di Sciascio G., Agrò F., Carassiti M., and Covino E. Effects of atorvastatin on systemic inflammatory response alter coronary bypass surgery. Crit Care Med 34 (2006) 660-667
16. Brull D.J., Sanders J., Rumley A., Lowe G.D., Humphries S.E., and Montgomery H.E. Statin therapy and the acute inflammatory response after coronary artery bypass grafting. Am J Cardiol 88 (2001) 431-433
17. Liakopoulos O.J., Dorge H., Schmitto J.D., Nagorsnik U., Grabedunkel J., and Schoendube F.A. Effects of preoperative statin therapy on cytokines after cardiac surgery. Thorac Cardiovasc Surg 54 (2006) 250-254
18. Chello M., Anselmo A., Spadaccio C., Patti G., Goffredo C., Di Sciascio G., and Covino E. Simvastatin increases neutrophil apoptosis and reduces inflammatory reaction alter coronary surgery. Ann Thorac Surg 83 (2007) 1374-1380
19. Knayzer B., Abramov D., Natalia B., Tovbin D., Ganiel A., and Katz A. Atrial fibrillation and plasma troponin I elevation after cardiac surgery: relation to inflammation-associated parameters. J Card Surg 22 (2007) 117-123
20. Cremer J., Martin M., Redl H., Bahrami S., Abraham C., Graeter T., Haverich A., Schlag G., and Borst H.G. Systemic inflammatory response syndrome after cardiac operations. Ann Thorac Surg 61 (1996) 1714-1720
21. Fransen E.J., Diris J.H., Maessen J.G., Hermens W.T., and van Dieijen-Visser M.P. Evaluation of "new" cardiac markers for ruling out myocardial infarction after coronary artery bypass grafting. Chest 122 (2002) 1316-1321
22. Adabag A.S., Rector T., Mithani S., Harmala J., Ward H.B., Kelly R.F., Nguyen J.T., McFalls E.O., and Bloomfield H.E. Prognostic significance of elevated cardiac troponin I after heart surgery. Ann Thorac Surg 83 (2007) 1744-1750
23. Croal B.L., Hillis G.S., and Gibson P.H. Relationship between postoperative cardiac troponin I levels and outcome of cardiac surgery. Circulation 114 (2006) 1468-1475
24. Vermes E., Mesguich M., Houel R., Soustelle C., Le Besnerais P., Hillion M.L., and Loisance D. Cardiac troponin I release after open heart surgery: a marker of myocardial protection?. Ann Thorac Surg 70 (2000) 2087-2090