Effects of preoperative statin therapy on cytokines after cardiac surgery

Thoracic and Cardiovascular Surgeon

Volumn 54, Issue 4, 2006, Pages 250-254

  Liakopoulos, Oliver J ^a,b   Dorge H ^a   Schmitto, J D ^a   Nagorsnik, U ^a   Grabedunkel J ^a   Schoendube, F A ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Cardiovascular surgery; Cytokines; Inflammatory response; Statins

Indexed keywords

ATORVASTATIN; CYTOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; I KAPPA B; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN; PRAVASTATIN; SIMVASTATIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DRUG EFFECT; FEMALE; HEART MUSCLE BIOPSY; HEART SURGERY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL;

AGED; ANTI-INFLAMMATORY AGENTS; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS; FEMALE; HEART ARREST, INDUCED; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; MALE; POSTOPERATIVE COMPLICATIONS; PRAVASTATIN; PROSPECTIVE STUDIES; PYRROLES; SIMVASTATIN; TIME FACTORS;

EID: 33745291076     PISSN: 01716425     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-923836     Document Type: Article

References (20)

1. Christenson JT. Preoperative lipid control with simvastatin protects coronary artery bypass grafts from obstructive graft disease. Am J Cardiol 2001; 88: 896-899
2. Knatterud GL, Rosenberg Y, Campeau L et al. Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators. Circulation 2000; 102: 157-165
3. Pan W, Pintar T, Anton J, Lee VV, Vaughn WK, Collard CD. Statins are associated with a reduced incidence of perioperative mortality after coronary artery bypass graft surgery. Circulation 2004; 110: 45-49
4. Schonbeck U, Libby P. Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents? Circulation 2004; 109: 18-26
5. Brull DJ, Sanders J, Rumley A, Lowe GD, Humphries SE, Montgomery HE. Statin therapy and the acute inflammatory response after coronary artery bypass grafting. Am J Cardiol 2001; 88: 431-433
6. Lazar HL, Bao Y, Zhang Y, Bernard SA. Pretreatment with statins enhances myocardial protection during coronary revascularization. J Thorac Cardiovasc Surg 2003; 125: 1037-1042
7. Hennein HA, Ebba H, Rodriguez JL et al. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization. J Thorac Cardiovasc Surg 1994; 108: 626-635
8. Onai Y, Suzuki J, Kakuta T et al. Inhibition of Ikappa B phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res 2004; 63: 51-59
9. Valen G, Paulsson G, Vaage J. Induction of inflammatory mediators during reperfusion of the human heart. Ann Thorac Surg 2001; 71: 226-232
10. Christman JW, Lancaster LH, Blackwell TS. Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 1998; 24: 1131-1138
11. Dichtl W, Dulak J, Frick M et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23: 58-63
12. Chello M, Mastroroberto P, Patti G et al. Simvastatin attenuates leucocyte-endothelial interactions after coronary revascularisation with cardiopulmonary bypass. Heart 2003; 89: 538-543
13. Liakopoulos OJ, Mühlfeld C, Koschinsky M, Coulibaly MO, Schoendube FA, Dörge H. Progressive loss of myocardial contractile function despite unimpaired coronary blood flow after cardiac surgery. Basic Res Cardiol 2005; 100: 75-83
14. Wan S, LeClerc JL, Vincent JL. Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation. Ann Thorac Surg 1997; 63: 269-276
15. Massy ZA, Kim Y, Guijarro C, Kasiske BL, Keane WF, O'Donnell MP. Low-density lipoprotein-induced expression of interleukin-6, a marker of human mesangial cell inflammation: effects of oxidation and modulation by lovastatin. Biochem Biophys Res Commun 2000; 267: 536-540
16. Florens E, Salvi S, Peynet J et al. Can statins reduce the inflammatory response to cardiopulmonary bypass? A clinical study. J Card Surg 2001; 16: 232-239
17. Sadeghi MM, Collinge M, Pardi R, Bender JR. Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. J Immunol 2000; 165: 2712-2718
18. Hölschermann H, Schuster D, Parviz B, Haberbosch W, Tillmanns H, Muth H. Statins prevent NF-κB transactivation independently of the IKK-pathway in human endothelial cells. Atherosclerosis 2006; 185: 240-245, Epub 2005 Jul 26
19. Rao S, Porter DC, Chen X, Herliczek T, Lowe M, Keyomarsi K. Lovastatin mediated G1 arrest is through inhibition of the proteosome, independent of hydroxymethyl glutaryl-CoA reductase. Proc Natl Acad Sci USA 1999; 96: 7797-7802
20. Ludwig A, Friedel B, Metzkow S et al. Effect of statins on the proteosomal activity in mammalian endothelial and vascular smooth cell muscle cells. Biochem Pharmacol 2005; 70: 520-526