Hawthorn extract reduces infarct volume and improves neurological score by reducing oxidative stress in rat brain following middle cerebral artery occlusion

International Journal of Developmental Neuroscience

Volumn 27, Issue 8, 2009, Pages 799-803

  Elango, Chinnasamy ^a   Jayachandaran, Kasevan Sawaminathan ^a   Niranjali Devaraj, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Cerebral ischemia reperfusion; Hawthorn extract; Middle cerebral artery occlusion; Oxidative stress; Stroke

Indexed keywords

CRATAEGUS EXTRACT; GLUTATHIONE; MALONALDEHYDE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; BRAIN INFARCTION; CRATAEGUS; GLUTATHIONE; INFARCTION, MIDDLE CEREBRAL ARTERY; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; CRATAEGUS; RATTUS;

EID: 70449526089     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2009.08.008     Document Type: Article

References (32)

1. Armagan G., Kanit L., Terek C.M., Sozmen E.Y., and Yalcin A. The levels of glutathione and nitrite-nitrate and the expression of Bcl-2 mRNA in ovariectomized rats treated by raloxifene against kainic acid. International Journal of Neuroscience 119 2 (2009) 227-239
2. Bahorun T., Trotin F., Pommery J., Vasseur J., and Pinkas M. Antioxidant activities of Crataegus monogyna extracts. Planta Medica 60 4 (1994) 323-328
3. Bahorun T., Gressier B., Trotin F., Brunet C., Dine T., Luyckx M., Vasseur J., Cazin M., Cazin J.C., and Pinkas M. Oxygen species scavenging activity of phenolic extracts from hawthorn fresh plant organs and pharmaceutical preparations. Arzneimittel-Forschung 46 11 (1996) 1086-1089
4. Bondy S.C. The relation of oxidative stress and hyperexcitation to neurological disease. Proceedings of Society for Experimental Biology and Medicine 208 4 (1995) 337-345
5. Brainin M., Teuschl Y., and Kalra L. Acute treatment and long-term management of stroke in developing countries. Lancet Neurology 6 6 (2007) 553-561
6. Brixius K., Willms S., Napp A., Tossios P., Ladage D., Bloch W., Mehlhorn U., and Schwinger R.H. Crataegus special extract WS 1442 induces an endothelium-dependent, NO-mediated vasorelaxation via eNOS-phosphorylation at serine1177. Cardiovascular Drugs and Therapy 20 3 (2006) 177-184
7. Bromont C., Marie C., and Bralet J. Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats. Stroke 20 7 (1989) 918-924
8. Chatterjee S.S., Koch E., Jaggy H., and Krzeminski T. In vitro and in vivo studies on the cardioprotective action of oligomeric procyanidins in a Crataegus extract of leaves and blooms. Arzneimittel-Forschung 47 7 (1997) 821-825
9. Cui K., Luo X., Xu K., and Ven Murthy M.R. Role of oxidative stress in neurodegeneration: recent developments in assay methods for oxidative stress and nutraceutical antioxidants. Progress in Neuro-psychopharmacology and Biological Psychiatry 28 5 (2004) 771-799
10. Estévez A.G., Radi R., Barbeito L., Shin J.T., Thompson J.A., and Beckman J.S. Peroxynitrite-induced cytotoxicity in PC12 cells: evidence for an apoptotic mechanism differentially modulated by neurotrophic factors. Journal of Neurochemistry 65 4 (1995) 1543-1550
11. Feigin V.L., Lawes C.M., Bennett D.A., and Anderson C.S. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurology 2 1 (2003) 43-53
12. Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs & Aging 18 9 (2001) 685-716
13. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., and Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265 5180 (1994) 1883-1885
14. Jayalakshmi R., and Niranjali Devaraj S. Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats. Journal of Pharmacy and Pharmacology 56 7 (2004) 921-926
15. Jayalakshmi R., Thirupurasundari C.J., and Devaraj S.N. Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol-induced myocardial infarction in rats. Molecular and Cellular Biochemistry 292 1-2 (2006) 59-67
16. Khan M., Elango C., Ansari M.A., Singh I., and Singh A.K. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. Journal of Neurochemistry 102 2 (2007) 365-377
17. Lee Y.A., Kim Y.J., Cho E.J., and Yokozawa T. Ameliorative effects of proanthocyanidin on oxidative stress and inflammation in streptozotocin-induced diabetic rats. Journal of Agricultural and Food Chemistry 14 55 (23) (2007) 9395-9400
18. Ljubuncic P., Portnaya I., Cogan U., Azaizeh H., and Bomzon A. Antioxidant activity of Crataegus aronia aqueous extract used in traditional Arab medicine in Israel. Journal of Ethnopharmacology 101 1-3 (2005) 153-161
19. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 1 (1989) 84-91
20. Long S.R., Carey R.A., Crofoot K.M., Proteau P.J., and Filtz T.M. Effect of hawthorn (Crataegus oxycantha) crude extract and chromatographic fractions on multiple activities in a cultured cardiomyocyte assay. Phytomedicine 13 9-10 (2006) 643-650
21. Mandel S., and Youdim M.B. Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases. Free Radical Biology and Medicine 37 3 (2004) 304-317
22. Miller N.D. Botanical influences on cardiovascular disease. Alternative Medicine Review 3 6 (1998) 423-430
23. Molan A.L., De S., and Meagher L. Antioxidant activity and polyphenol content of green tea flavan-3-ols and oligomeric proanthocyanidins. International Journal of Food Sciences and Nutrition 12 (2008) 1-10
24. Nazam Ansari M., Bhandari U., Islam F., and Tripathi C.D. Evaluation of antioxidant and neuroprotective effect of ethanolic extract of Embelia ribes Burm in focal cerebral ischemia/reperfusion-induced oxidative stress in rats. Fundamental and Clinical Pharmacology 22 3 (2008) 305-314
25. Peters O., Back T., Lindauer U., Busch C., Megow D., Dreier J., and Dirnagl U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. Journal of Cerebral Blood Flow and Metabolism 18 2 (1998) 196-205
26. Slemmer J.E., Shacka J.J., Sweeney M.I., and Weber J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Current Medicinal Chemistry 15 4 (2008) 404-414
27. Thiyagarajan M., and Sharma S.S. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sciences 74 8 (2004) 969-985
28. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Analytical Biochemistry 27 3 (1969) 502-522
29. Traystman R.J., Kirsch J.R., and Koehler R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. Journal of Applied Physiology 71 4 (1991) 1185-1195
30. Vakili A., and Zahedi khorasani M. Post-ischemic treatment of pentoxifylline reduces cortical not striatal infarct volume in transient model of focal cerebral ischemia in rat. Brain Research 1144 (2007) 186-191
31. Veveris M., Koch E., and Chatterjee S.S. Crataegus special extract WS 1442 improves cardiac function and reduces infarct size in a rat model of prolonged coronary ischemia and reperfusion. Life Sciences 74 15 (2004) 1945-1955
32. Zhang D.L., Zhang Y.T., Yin J.J., and Zhao B.L. Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. Journal of Neurochemistry 90 1 (2004) 211-219