Development of an ex vivo method for evaluation of precorneal residence of topical ophthalmic formulations

AAPS PharmSciTech

Volumn 10, Issue 3, 2009, Pages 796-805

  Liu, Quan ^a   Wang, Youmin ^b  

^a TEMPLE UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Ex vivo; Ophthalmic formulation; Perfusion; Residence; Retention

Indexed keywords

AGENTS ACTING ON THE EYE; ALGINIC ACID; CALCIUM CHLORIDE; CARBOPOL 974P; CARBOXYMETHYLCELLULOSE; HYALURONIC ACID; HYDROXYPROPYLMETHYLCELLULOSE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG FORMULATION; DRUG RETENTION; EX VIVO STUDY; FLOW KINETICS; FLOW RATE; FLUORESCENCE MICROSCOPY; MEMBRANE PERMEABILITY; NONHUMAN; PERFUSION; RAT; VISCOELASTICITY;

ADMINISTRATION, TOPICAL; ALGINATES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CORNEA; ELASTICITY; EXCIPIENTS; MALE; METHYLCELLULOSE; MODELS, STATISTICAL; MUCINS; OPHTHALMIC SOLUTIONS; PHARMACEUTICAL SOLUTIONS; POLYVINYLS; RATS; RHEOLOGY; SPECTROMETRY, FLUORESCENCE; VISCOSITY;

EID: 70449525334     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9266-6     Document Type: Article

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