Optimized conditions for the extraction of eupatilin in Artemisia asiatica by pressurized liquid extraction

Separation Science and Technology

Volumn 44, Issue 8, 2009, Pages 1772-1783

  Kim, Seung Hyun ^a   Park, Jin Ho ^a   Kim, Bo Ram ^a   Kim, Eun Ju ^b   Kim, Hyo Jin ^c   Cho, Yekyung ^b   Lee, Ki Yong ^b   Sung, Sang Hyun ^b  

^a Elcomscience Co Ltd   (South Korea)

^b Seoul National University   (South Korea)

^c Dongduk Women's University   (South Korea)

Author keywords

Artemisia asiatica; Ethanol proportion; Eupatilin; Pressurized liquid extraction; Temperature

Indexed keywords

ARTEMISIA ASIATICA; CENTRAL COMPOSITE DESIGNS; DIODE ARRAY DETECTORS; EFFECT OF TEMPERATURE; EUPATILIN; EXTRACTION EFFICIENCIES; HIGH TEMPERATURE; OPTIMIZED CONDITIONS; PRESSURIZED LIQUID EXTRACTION; RESPONSE SURFACE ANALYSIS; TWO PARAMETER;

CHROMATOGRAPHIC ANALYSIS; ETHANOL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; SURFACE ANALYSIS; THERMAL EFFECTS;

SOLVENT EXTRACTION;

ALCOHOL; COMPOSITE; DETECTOR; EXTRACTION METHOD; PATTERN (PLAN);

EID: 70449515108     PISSN: 01496395     EISSN: 15205754     Source Type: Journal    
DOI: 10.1080/01496390902775794     Document Type: Article

References (18)

1. Kinghorn, A.D. (2001) Pharmacognosy in the 21st century. J. Pharm. Pharmacol, 53: 135.
2. Lim, B.O.; Chung, H.G.; Lee, W.H.; Lee, H.W.; Suk, K. (2008) Inhibition of microglial neurotoxicity by ethanol extract of Artemisia asiatica Nakai. Phytother. Res., 22: 279.
3. Oh, T.Y.; Shin, C.Y.; Shon, Y.S.; Kim, D.H.; Ahn, B.O.; Lee, E.B.; Park, C.H. (2005) Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats. World J. Gastroenterol., 11: 7430.
4. Choi, E.J.; Oh, H.M.; Na, B.R.; Ramesh, T.P.; Lee, H.J.; Choi, C.S.; Choi, S.C.; Oh, T.Y.; Choi, S.J.; Chae, J.R.; Kim, S.W.; Jun, C.D. (2008) Eupatilin protects gastric epithelial cells from oxidative damage and down-regulates genes responsible for the cellular oxidative stress. Pharm. Res., 25: 1355.
5. Park, S.C.; Yoon, J.H.; Kim, W.; Gwak, G.Y.; Kim, K.M.; Lee, S.H.; Lee, S.M.; Lee, H.S. (2006) Eupatilin attenuates bile acid-induced hepatocyte apoptosis. J. Gastroenterol., 41: 772.
6. Lee, S.H.; Bae, E.A.; Park, E.K.; Shin, Y.W.; Baek, N.I.; Han, E.J.; Chung, H.G.; Kim, D.H. (2007) Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. Int. Immunopharma- col., 7: 1678.
7. Yang, J. (1995) DA-9601, an Artemisiae extract of antiulcer agent. Final report of Good Health R&D Program, Ministry of Health and Welfare, Republic of Korea.
8. Wang, L.; Weller, C.L. (2006) Recent advances in extraction of nutraceuticals from plants. Trends Food Sci. Technol., 17: 300.
9. Seidel, V. (2006) Extraction. In: Natural Product Isolation, 2nd Ed.; Sarker, S.D.; Latif, Z.; Gray, A.I. eds.; Humana Press: New Jersey, U.S.A.
10. Huie, C.W. (2002) A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants. Anal. Bioanal. Chem., 373: 23.
11. Ryu, S.N.; Kang, S.S.; Kim, J.S.; Ku, B.I. (2004) Quantitative analysis of eupatilin and jaceosidin in Artemisia herba. Korean J. Crop Sci., 49: 452.
12. Escarpa, A.; Gonzalez, M.C. (1999) Fast separation of (poly)phenolic compounds from apples and pears by high-performance liquid chromatography with diode-array detection. J. Chromatogr. A, 830: 301.
13. Silva, E.M.; Rogez, H.; Larondelle, Y. (2007) Optimization of extraction of phenolics from Inga edulis leaves using response surface methodology. Sep. Pur. Technol., 55: 381.
14. Urbonavičiut, A.; Jakstas, V.; Kornysova, O.; Janulis, V.; Marusk, A. (2006) Capillary electrophoretic analysis of flavonoids in single-styled hawthorn (Crataegus monogyna Jacq.) ethanolic extracts. J. Chromatogr. A, 1112: 339.
15. Luthria, D. (2008) Influence of experimental conditions on the extraction of phenolic compounds from parsley (Petroselinum crispum) flakes using a pressurized liquid extractor. Food Chem., 107: 745.
16. Mukhopadhyay, S.; Luthria, D.L.; Robbins, R.J. (2006) Optimization of extraction process for phenolic acids from black cohosh (Cimicifuga racemosa) by pressurized liquid extraction. J. Sci. Food Agric., 86: 156.
17. Rostagno, M.A.; Palma, M.; Barroso, C.G. (2004) Pressurized liquid extraction of isoflavones from soybeans. Anal. Chim. Acta, 522: 169.
18. Myer, R.H.; Montgomery, D.C. (1995) Response surface methodology: Process and product optimization using designed experiments; Wiley & Sons Inc.: New York, U.S.A.