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1
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47949087545
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WO 2003/002531 A., CAN 138: 900712003
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(a) Haffner, C. D.; McDougald, D. L.; Randhawa, A. S.; Reister, S. M.; Lenhard, J. M. PCT Int. Appl. WO 2003/002531 A, 2003; CAN 138: 900712003.
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Haffner, C.D.1
McDougald, D.L.2
Randhawa, A.S.3
Reister, S.M.4
Lenhard, J.M.5
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3
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34547223622
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(a) For recent reports, see: Hanson, R. L.; Goldberg, S. L.; Brzozowski, D. B.; Tully, T. P.; Cazzulino, D.; Parker, W. L.; Lyngberg, O. K.; Vu, T. C.; Wong, M. K.; Patel, R. N. Adv. Synth. Catal. 2007, 349, 1369.
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Hanson, R.L.1
Goldberg, S.L.2
Brzozowski, D.B.3
Tully, T.P.4
Cazzulino, D.5
Parker, W.L.6
Lyngberg, O.K.7
Vu, T.C.8
Wong, M.K.9
Patel, R.N.10
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4
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34248999413
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(b) Feng, J.; Zhang, Z.; Wallace, M. B.; Stafford, J. A.; Kaldor, S. W.; Kassel, D. B.; Navre, M.; Shi, L.; Skene, R. J.; Asakawa, T.; Takeuchi, K.; Xu, R.; Webb, D. R.; Gwaltney, S. L. J. Med. Chem. 2007, 50, 2297.
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Feng, J.1
Zhang, Z.2
Wallace, M.B.3
Stafford, J.A.4
Kaldor, S.W.5
Kassel, D.B.6
Navre, M.7
Shi, L.8
Skene, R.J.9
Asakawa, T.10
Takeuchi, K.11
Xu, R.12
Webb, D.R.13
Gwaltney, S.L.14
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5
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34247204289
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(c) Pei, Z.; Li, X.; von Geldern, T. W.; Longnecker, K.; Pireh, D.; Stewart, K. D.; Bakes, B. J.; Lai, C.; Lubben, T. H.; Ballaron, S. J.; Beno, D. W. A.; Kempf-Grote, A. J.; Sham, H. L.; Trevillyan, J. M. J. Med. Chem. 2007, 50, 1983.
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Pei, Z.1
Li, X.2
Von Geldern, T.W.3
Longnecker, K.4
Pireh, D.5
Stewart, K.D.6
Bakes, B.J.7
Lai, C.8
Lubben, T.H.9
Ballaron, S.J.10
Beno, D.W.A.11
Kempf-Grote, A.J.12
Sham, H.L.13
Trevillyan, J.M.14
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6
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36349006502
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(a) Patterson, D. E.; Xie, S.; Jones, L. A.; Osterhout, M. H.; Henry, C. G.; Roper, T. D. Org. Process Res. Dev. 2007, 11, 624.
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Patterson, D.E.1
Xie, S.2
Jones, L.A.3
Osterhout, M.H.4
Henry, C.G.5
Roper, T.D.6
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7
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53149137375
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(b) For another approach to 4, see: Deng, G.; Ye, D.; Li, Y.; He, L.; Zhou, Y.; Wang, J.; Li, J.; Jiang, H.; Liu, H. Tetrahedron 2008, 64, 10512.
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Deng, G.1
Ye, D.2
Li, Y.3
He, L.4
Zhou, Y.5
Wang, J.6
Li, J.7
Jiang, H.8
Liu, H.9
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8
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18644382329
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(c) For a synthesis of 2 see: Doi, M.; Nishi, Y.; Kiritoshi, N.; Iwata, T.; Nago, M.; Nakano, H.; Uchiyama, S.; Nakazawa, T.; Wakamiya, T.; Kobayashi, Y. Tetrahedron 2002, 58, 8453.
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Doi, M.1
Nishi, Y.2
Kiritoshi, N.3
Iwata, T.4
Nago, M.5
Nakano, H.6
Uchiyama, S.7
Nakazawa, T.8
Wakamiya, T.9
Kobayashi, Y.10
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9
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28944443142
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Dunn, P. J.; Hoffman, W.; Kang, Y.; Mitchell, J. C.; Snowden, M. J. Org. Process Res. Dev. 2005, 9, 956.
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Org. Process Res. Dev.
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Dunn, P.J.1
Hoffman, W.2
Kang, Y.3
Mitchell, J.C.4
Snowden, M.J.5
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10
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70449388405
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Data from GSK Process Safety group. Energy of decomposition determined by DSC testing at 2 K/min. Maximum operating temperature determined by ARC testing
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Data from GSK Process Safety group. Energy of decomposition determined by DSC testing at 2 K/min. Maximum operating temperature determined by ARC testing.
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11
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0037013834
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(a) Garrett, C. E.; Jiang, X.; Prasad, K.; Repic, O. Tetrahedron Lett. 2002, 43, 4161.
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Tetrahedron Lett
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Garrett, C.E.1
Jiang, X.2
Prasad, K.3
Repic, O.4
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13
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70449341046
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T3P is a registered trademark of Clariant
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T3P is a registered trademark of Clariant.
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14
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84985579731
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(a) Wissmann, H.; Kleiner, H. J. Angew. Chem., Int. Ed. Engl. 1980, 19, 133.
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Wissmann, H.1
Kleiner, H.J.2
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15
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39049118455
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(b) Boggs, S. D.; Cobb, J. D.; Gudmundsson, K. S.; Jones, L. J.; Matsuoka, R. T.; Millar, A.; Patterson, D. E.; Samano, V.; Trone, M. D.; Xie, S.; Zhou, X.-M. Org. Process Res. Dev. 2007, 11, 539.
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Org. Process Res. Dev.
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Boggs, S.D.1
Cobb, J.D.2
Gudmundsson, K.S.3
Jones, L.J.4
Matsuoka, R.T.5
Millar, A.6
Patterson, D.E.7
Samano, V.8
Trone, M.D.9
Xie, S.10
Zhou, X.-M.11
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16
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2942628374
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(c) Helal, C. J.; Kang, Z.; Lucas, J. C.; Bohall, B. R. Org. Lett. 2004, 6, 1853.
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Helal, C.J.1
Kang, Z.2
Lucas, J.C.3
Bohall, B.R.4
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18
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70449417139
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The identity of the intermediates 7 and 8 are based on LC-MS analysis
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The identity of the intermediates 7 and 8 are based on LC-MS analysis.
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