Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy

Planta Medica

Volumn 75, Issue 12, 2009, Pages 1300-1305

  Huang, Chung Hsiung ^a   Ku, Chun Yao ^a   Jan, Tong Rong ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Diosgenin; Food allergy; IgE; Mast cells; Ovalbumin

Indexed keywords

DIOSGENIN; FOOD ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; OVALBUMIN;

ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; CELL INFILTRATION; CONTROLLED STUDY; DEGRANULATION; DIARRHEA; ENTERITIS; FEEDING; FOOD ALLERGY; GOBLET CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; IN VIVO STUDY; MALE; MAST CELL; MOUSE; NONHUMAN;

ALLERGENS; ANIMALS; DIOSGENIN; DISEASE MODELS, ANIMAL; FOOD HYPERSENSITIVITY; IMMUNOGLOBULIN E; MALE; MICE; MICE, INBRED BALB C;

DIOSCOREA POLYSTACHYA; MURINAE; MUS;

EID: 70449441241     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185578     Document Type: Article

References (24)

1. Choi EM, Koo SJ, Hwang JK. Immune cell stimulating activity of mucopolysaccharide isolated from yam (Dioscorea batatas). J Ethnopharmacol 2004; 91: 1-6
2. Shi HQ, Li MJ, Song AX, Liu XH. RP-HPLC determination of diosgenin in Dioscorea opposita Thunb and D. alata L. Chin J Pharm Anal 2004; 24: 465-467
3. Wanasundera JP, Ravindran G. Nutritional assessment of yam (Dioscorea alata) tubers. Plant Foods Hum Nutr 1994; 46: 33-39
4. Kamisako T, Ogawa H. Regulation of biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: effects of diosgenin and ethinylestradiol. Hepatol Res 2003; 26: 348-352
5. McAnuff MA, HardingWW, Omoruyi FO, Jacobs H, Morrison EY, Asemota HN. Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides. Food Chem Toxicol 2005; 43: 1667-1672
6. Sautour M, Mitaine-Offer AC, Miyamoto T, Dongmo A, Lacaille-Dubois MA. Antifungal steroid saponins from Dioscorea cayenensis. Planta Med 2004; 70: 90-92
7. Yin J, Tezuka Y, Kouda K, Le Tran Q, Miyahara T, Chen Y, Kadota S. In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin. Planta Med 2004; 70: 220-226
8. Kim MJ, Kim HN, Kang KS, Baek NI, Kim DK, Kim YS, Jeon BH, Kim SH. Methanol extract of Dioscoreae Rhizoma inhibits pro-inflammatory cytokines and mediators in the synoviocytes of rheumatoid arthritis. Int Immunopharmacol 2004; 4: 1489-1497
9. Choi EM, Hwang JK. Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage. Fitoterapia 2002; 73: 629-637
10. Jan TR,Wey SP, Kuan CC, LiaoMH, Wu HY. Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice. Planta Med 2007; 73: 421-426
11. Lin JY, Lu S, Liou YL, Liou HL. Increased IgA and IgG serum levels using a novel yam-boxthorn noodle in a BALB/cmousemodel. Food Chem Toxicol 2006; 44: 170-178
12. Grundy J, Matthews S, Bateman B, Dean T, Arshad SH. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002; 110: 784-789
13. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol 2003; 112: 1203-1207
14. Burks W, Helm R, Stanley S, Bannon GA. Food allergens. Curr Opin Allergy Clin Immunol 2001; 1: 243-248
15. Fogg MI, Spergel JM. Management of food allergies. Expert Opin Pharmacother 2003; 4: 1025-1037
16. Burks W, Kulis M, Pons L. Food allergies and hypersensitivity: a review of pharmacotherapy and therapeutic strategies. Expert Opin Pharmacother 2008; 9: 1145-1152
17. Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997; 18: 263-266
18. Brandt EB, Strait RT, Hershko D, Wang Q, Muntel EE, Scribner TA, Zimmermann N, Finkelman FD, Rothenberg ME. Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 2003; 112: 1666-1677
19. Knight AK, Blazquez AB, Zhang S, Mayer L, Sampson HA, Berin MC. CD4 T cells activated in the mesenteric lymph node mediate gastrointestinal food allergy inmice. Am J Physiol Gastrointest Liver Physiol 2007; 293: G1234-G1243
20. van Halteren AG, van der Cammen MJ, Biewenga J, Savelkoul HF, Kraal G. IgE and mast cell response on intestinal allergen exposure: a murine model to study the onset of food allergy. J Allergy Clin Immunol 1997; 99: 94-99
21. Knippels LM, van Wijk F, Penninks AH. Food allergy: what do we learn from animal models? Curr Opin Allergy Clin Immunol 2004; 4: 205-209
22. Iweala OI, Nagler CR. Immune privilege in the gut: the establishment and maintenance of non-responsiveness to dietary antigens and commensal flora. Immunol Rev 2006; 213: 82-100
23. Kim H, Kwack K, Kim DY, Ji GE. Oral probiotic bacterial administration suppressed allergic responses in an ovalbumin-induced allergy mouse model. FEMS Immunol Med Microbiol 2005; 45: 259-267
24. Kim JY, Choi YO, Ji GE. Effect of oral probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) administration on ovalbumin-induced food allergy mouse model. J Microbiol Biotechnol 2008; 18: 1393-1400