P110 and P140 cytadherence-related proteins are negative effectors of terminal organelle duplication in Mycoplasma genitalium

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Pich, Oscar Q ^a,b   Burgos, Raul ^a   Querol, Enrique ^a   Piñol, Jaume ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ADHESIN; BACTERIAL DNA; PROTEIN P110; PROTEIN P140; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BACTERIAL VIRULENCE; CELL ADHESION; CELL MOTILITY; CELL ORGANELLE; CONTROLLED STUDY; DNA CONTENT; DNA REPLICATION; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; MUTATIONAL ANALYSIS; MYCOPLASMA GENITALIUM; NONHUMAN; PHENOTYPE; QUANTITATIVE STUDY; TERMINAL ORGANELLE DUPLICATION; TRANSPOSON; WILD TYPE; BACTERIAL GENE; BACTERIUM ADHERENCE; BIOLOGICAL MODEL; CELL DIVISION; CELL MOTION; COMPUTER PROGRAM; CYTOSKELETON; GENE EXPRESSION REGULATION; METABOLISM; METHODOLOGY; MUTATION; TRANSMISSION ELECTRON MICROSCOPY;

MYCOPLASMA; MYCOPLASMA GENITALIUM; MYCOPLASMATALES;

ADHESINS, BACTERIAL; BACTERIAL ADHESION; CELL ADHESION; CELL DIVISION; CELL MOVEMENT; CYTOSKELETON; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, GENETIC; MUTATION; MYCOPLASMA GENITALIUM; ORGANELLES; PHENOTYPE; SOFTWARE;

EID: 70449369826     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007452     Document Type: Article

References (33)

1. Hegermann J, Herrmann R, Mayer F (2002) Cytoskeletal elements in the bacterium Mycoplasma pneumoniae. Naturwissenschaften 89: 453-458.
2. Nakane D, Miyata M (2007) Cytoskeletal "jellyfish" structure of Mycoplasma mobile. Proc Natl Acad Sci U S A 104: 19518-19523.
3. Rosengarten R, Kirchhoff H (1987) Gliding motility of Mycoplasma sp. nov. strain 163K. J Bacteriol 169: 1891-1898.
4. Bredt W, Radestock U (1977) Gliding motility of Mycoplasma pulmonis. J Bacteriol 130: 937-938.
5. Taylor-Robinson D, Bredt W (1983) Motility of Mycoplasma strain G37. Yale J Biol Med 56: 910.
6. Hatchel JM, Balish MF (2008) Attachment organelle ultrastructure correlates with phylogeny, not gliding motility properties, in Mycoplasma pneumoniae relatives. Microbiology 154: 286-295.
7. Hatchel JM, Balish RS, Duley ML, Balish MF (2006) Ultrastructure and gliding motility of Mycoplasma amphoriforme, a possible human respiratory pathogen. Microbiology 152: 2181-2189.
8. Radestock U, Bredt W (1977) Motility of Mycoplasma pneumoniae. J Bacteriol 129: 1495-1501.
9. Fraser CM, Gocayne JD, White O, Adams MD, Clayton RA, et al. (1995) The minimal gene complement of Mycoplasma genitalium. Science 270: 397-403.
10. Herrmann R, Reiner B (1998) Mycoplasma pneumoniae and Mycoplasma genitalium: a comparison of two closely related bacterial species. Curr Opin Microbiol 1: 572-579.
11. Regula JT, Boguth G, Gorg A, Hegermann J, Mayer F, et al. (2001) Defining the mycoplasma 'cytoskeleton': the protein composition of the Triton X-100 insoluble fraction of the bacterium Mycoplasma pneumoniae determined by 2-D gel electrophoresis and mass spectrometry. Microbiology 147: 1045-1057.
12. Gobel U, Speth V, Bredt W (1981) Filamentous structures in adherent Mycoplasma pneumoniae cells treated with nonionic detergents. J Cell Biol 91: 537-543.
13. Pich OQ, Burgos R, Ferrer-Navarro M, Querol E, Pinol J (2008) Role of Mycoplasma genitalium MG218 and MG317 cytoskeletal proteins in terminal organelle organization, gliding motility and cytadherence. Microbiology 154: 3188-3198.
14. Meng KE, Pfister RM (1980) Intracellular structures of Mycoplasma pneumoniae revealed after membrane removal. J Bacteriol 144: 390-399.
15. Hasselbring BM, Krause DC (2007) Cytoskeletal protein P41 is required to anchor the terminal organelle of the wall-less prokaryote Mycoplasma pneumoniae. Mol Microbiol 63: 44-53.
16. Burgos R, Pich OQ, Querol E, Pinol J (2008) Deletion of the Mycoplasma genitalium MG_217 gene modifies cell gliding behaviour by altering terminal organelle curvature. Mol Microbiol 69: 1029-1040.
17. Pich OQ, Burgos R, Ferrer-Navarro M, Querol E, Pinol J (2006) Mycoplasma genitalium mg200 and mg386 genes are involved in gliding motility but not in cytadherence. Mol Microbiol 60: 1509-1519.
18. Boatman ES (1979) Morphology and ultrastructure of the mycoplasmatales. In: Barile MF, Razin S, eds. The mycoplasmas, vol I. New York: Academic Press. pp 63-102.
19. Bredt W (1968) Motility and multiplication of Mycoplasma pneumoniae. A phase contrast study. Pathol Microbiol (Basel) 32: 321-326.
20. Hasselbring BM, Jordan JL, Krause RW, Krause DC (2006) Terminal organelle development in the cell wall-less bacterium Mycoplasma pneumoniae. Proc Natl Acad Sci U S A 103: 16478-16483.
21. Seto S, Layh-Schmitt G, Kenri T, Miyata M (2001) Visualization of the attachment organelle and cytadherence proteins of Mycoplasma pneumoniae by immunofluorescence microscopy. J Bacteriol 183: 1621-1630.
22. Quinlan DC, Maniloff J (1972) Membrane association of the deoxyribonucleic acid growing-point region in Mycoplasma gallisepticum. J Bacteriol 112: 1375-1379.
23. Burgos R, Pich OQ, Querol E, Pinol J (2007) Functional analysis of the Mycoplasma genitalium MG312 protein reveals a specific requirement of the MG312 N-terminal domain for gliding motility. J Bacteriol 189: 7014-7023.
24. Burgos R, Pich OQ, Ferrer-Navarro M, Baseman JB, Querol E, et al. (2006) Mycoplasma genitalium P140 and P110 cytadhesins are reciprocally stabilized and required for cell adhesion and terminal-organelle development. J Bacteriol 188: 8627-8637.
25. Hasselbring BM, Krause DC (2007) Proteins P24 and P41 function in the regulation of terminal-organelle development and gliding motility in Mycoplasma pneumoniae. J Bacteriol 189: 7442-7449.
26. Hu PC, Schaper U, Collier AM, Clyde WA Jr, Horikawa M, et al. (1987) A Mycoplasma genitalium protein resembling the Mycoplasma pneumoniae attachment protein. Infect Immun 55: 1126-1131.
27. Miyata M, Yamamoto H, Shimizu T, Uenoyama A, Citti C, et al. (2000) Gliding mutants of Mycoplasma mobile: relationships between motility and cell morphology, cell adhesion and microcolony formation. Microbiology 146 (Pt 6): 1311-1320.
28. Hasselbring BM, Page CA, Sheppard ES, Krause DC (2006) Transposon mutagenesis identifies genes associated with Mycoplasma pneumoniae gliding motility. J Bacteriol 188: 6335-6345.
29. Mernaugh GR, Dallo SF, Holt SC, Baseman JB (1993) Properties of adhering and nonadhering populations of Mycoplasma genitalium. Clin Infect Dis 17 Suppl 1: S69-78.
30. Lluch-Senar M, Vallmitjana M, Querol E, Pinol J (2007) A new promoterless reporter vector reveals antisense transcription in Mycoplasma genitalium. Microbiology 153: 2743-2752.
31. Hottes AK, Shapiro L, McAdams HH (2005) DnaA coordinates replication initiation and cell cycle transcription in Caulobacter crescentus. Mol Microbiol 58: 1340-1353.
32. Pich OQ, Burgos R, Planell R, Querol E, Pinol J (2006) Comparative analysis of antibiotic resistance gene markers in Mycoplasma genitalium: application to studies of the minimal gene complement. Microbiology 152: 519-527.
33. Tully JG, Rose DL, Whitcomb RF, Wenzel RP (1979) Enhanced isolation of Mycoplasma pneumoniae from throat washings with a newly-modified culture medium. J Infect Dis 139: 478-482.