Lack of aspartoacylase activity disrupts survival and differentiation of neural progenitors and oligodendrocytes in a mouse model of Canavan disease

Journal of Neuroscience Research

Volumn 87, Issue 15, 2009, Pages 3415-3427

  Kumar, Shalini ^a   Biancotti, Juan Carlos ^a   Matalon, Reuben ^b   De Vellis, Jean ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Apoptosis; Demyelination; Gene expression; Histone acetylation; Oligodendrocyte progenitors; Proliferation

Indexed keywords

ASPARTOACYLASE; BROXURIDINE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HISTONE H2B; HISTONE H3; KI 67 ANTIGEN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CANAVAN DISEASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DEATH; CELL FATE; CELL LINEAGE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE FUNCTION; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION;

AMIDOHYDROLASES; ANIMALS; BIOLOGICAL MARKERS; BRAIN; CANAVAN DISEASE; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONES; MICE; MICE, KNOCKOUT; MYELIN PROTEINS; NERVE DEGENERATION; OLIGODENDROGLIA; PROTEIN TRANSPORT; RNA, MESSENGER; STEM CELLS;

EID: 70449346685     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22233     Document Type: Article

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