Interventional effect of Ginkgo biloba extract on the progression of gastric precancerous lesions in rats

Journal of Digestive Diseases

Volumn 10, Issue 4, 2009, Pages 293-299

  Jiang, Xiao Yun ^a   Qian, Li Ping ^a   Zheng, Xiao Juan ^b   Xia, Yu Ye ^b   Jiang, Yi Bin ^a   Sun, Da Yu ^a  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Institute of Pharmaceutical Industry   (China)

Author keywords

Gastric precancerous lesions; Ginkgo biloba extract; MDA; Oncogene; SOD

Indexed keywords

FAS LIGAND; GINKGO BILOBA EXTRACT; MALONALDEHYDE; METHYLNITRONITROSOGUANIDINE; MYC PROTEIN; PROTEIN BCL 2; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DYSPLASIA; ENZYME ACTIVITY; GENE EXPRESSION; HISTOPATHOLOGY; INTESTINE METAPLASIA; LOW DRUG DOSE; MALE; NONHUMAN; ONCOGENE; PRECANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA; STOMACH TUMOR; TISSUE LEVEL; TREATMENT DURATION; WISTAR RAT;

ANIMALS; ANTIGENS, CD95; ANTIOXIDANTS; APOPTOSIS; BODY WEIGHT; CELL DIVISION; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; GASTRIC MUCOSA; GASTRITIS; GENE EXPRESSION; GINKGO BILOBA; MALONDIALDEHYDE; METHYLNITRONITROSOGUANIDINE; PLANT EXTRACTS; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, WISTAR; SERUM ALBUMIN; STOMACH NEOPLASMS; SUPEROXIDE DISMUTASE;

EID: 70449133778     PISSN: 17512972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-2980.2009.00398.x     Document Type: Article

References (25)

1. Biopsy pathology of stomach and duodenum mucosa. 1981, National Cooperative Group for the Research on Prevention and Treatment of Gastric Cancer (Pathology Group), Liaoning Peoples Publishing House
2. Chunlin W, Fang G, Hailong H, Yongli W. Study progress on pharmacological activities of Ginkgo biloba extract. J Hebei Med 2005, 24:286-7. in Chinese
3. Bridi R, Crossetti FP, Steffen VM, Henriques AT. The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytother Res 2001, 15:449-51.
4. Yufeng J, Jinhuo H, Hongjiang L. Experimental study on antitumor effects of Ginkgo biloba extract. Traditional Chinese Medicinal Res 2005, 18:14-16. in Chinese
5. Yuan G, Xuan G, Liguo A. Research on antitumor effects of Ginkgo biloba flavonoids. Practical J Medicine Pharmacy 2002, 19:770-1. in Chinese
6. Li W, Pretner E, Shen L, Drieu K, Papadopoulos V. Common gene targets of Ginkgo biloba extract (EGb 761) in human tumor cells: relation to cell growth. Anticancer Res 2006, 26:9-22. in Chinese
7. Yang XM, Chen YC, Chen J, Xie JM. Apoptosis study on human or leukaemia cell line U937 induced by ginkgolic acids from Ginkgo biloba L. Food Science 2006, 27:241-6. in Chinese
8. Agha AM, El-Fattah AA, Al-Zuhair HH, Al-Rikabi AC. Chemopreventive effect of Ginkgo biloba extract against benzo(a)pyrene-induced forestomach carcinogenesis in mice: amelioration of doxorubicin cardiotoxicity. J Exp Clin Cancer Res 2001, 20:39-50.
9. Dias MC, Rodrigues MA, Reimberg MC, Barbisan LF. Protective effects of Ginkgo biloba against rat liver carcinogenesis. Chem Biol Interact 2008, 173:32-42.
10. Shangyong Y, Kejun N, Shengjie C, Chuangxin L, Ying K. Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008, 28:68-70. in Chinese
11. Hauns B, Häring B, Köhler S, Mross K, Robben-Bathe P, Unger C. Phase II study with 5-fluorouracil and ginkgo biloba extract (GBE 761 ONC) in patients with pancreatic cancer. Arzneimittelforschung 1999, 49:1030-4.
12. Hauns B, Häring B, Köhler S, Mross K, Robben-Bathe P, Unger C. Phase II study of combined 5-fluorouracil/Ginkgo biloba extract (GBE 761 ONC) therapy in 5-fluorouracil pretreated patients with advanced colorectal cancer. Phytother Res 2001, 15:34-8.
13. Ming SC. Cellular and molecular pathology of gastric carcinoma and precursor lesions: a critical review. Gastric Cancer 1998, 1:31-50.
14. Guiyin S, Weiwen L, Zhiqiang Z, Dianchun F, Rongpu M, Yuanhui L. Effects of free radical on the development of experimental gastric cancer and precancerous lesions. World J Gastroenterol 1998, 6:219-21. in Chinese
15. Farinati F, Cardin R, Degan P. Oxidative DNA damage accumulation in gastric carcinogenesis. Gut 1998, 42:351-6.
16. Qiong P, Xiuling W. Clinical significance of measurement of lipid peroxides in gastric cancer and intestinal metaplasia tissue. Central Plains Med J 2000, 27:50. in Chinese
17. Defeudis FV, Papadopoulos V, Drieu K. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol 2003, 17:405-17.
18. Na Z, Yongyan X, Jing L. Relationship of helicobacter pylori infection with the expression of c-myc, Bcl-2, bax in various gastric mucosal lesions. Cancer 2003, 22:1034-7. in Chinese
19. Hua M, Lin L, Shen L. Gastric mucosal epithelia hyperplasia and the expression of apoptosis-related gene protein in gastric cancer and precancerous lesion. World J Gastroenterol 2004, 12:494-6. in Chinese
20. Sujuan Q, Lingwang Z, Yueming C, Xiuyun Y, Shanlin G, Ge L. Relationship of expression of Bcl-2 protein with gastric cell apoptosis. J Harbin Med Univ 1998, 32:6-7. in Chinese
21. Haifeng L, Weiwen L, Dianchun F, Guoan W, Xiaochun T, Gang C. Regulating effect of expression of Bcl-2 gene in gastric cancer and gastric precancerous lesion and its cell apoptosis. J Third Military Med Univ 2004, 26:580-3. in Chinese
22. Bofen Z, Xuewei Z, Ying X, Yuyang S. Relativity of FAS/FasL with gastrointestinal tumors. J Microbiol 2003, 23:56-62. in Chinese
23. Haifeng L, Weiwen L, Dianchun F, Rongpu M. Relationship of cell apoptosis with the ldeexpression of FasL in gastric precancerous lesion and gastric cancer. World J Gastroenterol 1999, 7:561-3. in Chinese
24. Ohno S, Tachibana M, Shibakita M. Prognostic significance of Fas and FasL system associated apoptosis in gastric carcinomas. Ann Surg Oncol 2000, 7:750-7.
25. Lee TB, Min YD, Lim SC. Fas(Apo-1/CD95) and Fas ligand interaction between gastric cancer cells and immune cells. Gastrolentezol Hepatol 2002, 17:32-8.