An update on P-glycoprotein and drug resistance in Schistosoma mansoni

Trends in Parasitology

Volumn 25, Issue 12, 2009, Pages 538-539

  James, Catherine E ^a   Hudson, Amanda L ^a   Davey, Mary W ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CYCLOSPORIN A; GLYCOPROTEIN P; INDOMETACIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; PRAZIQUANTEL; RESORUFIN; RNA; VERAPAMIL;

ANTIBIOTIC RESISTANCE; CAENORHABDITIS ELEGANS; DRUG MECHANISM; HUMAN; IMMUNOREACTIVITY; LETTER; NONHUMAN; POLYPHARMACY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

ANIMALS; ANTHELMINTICS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; P-GLYCOPROTEIN; PRAZIQUANTEL; SCHISTOSOMA MANSONI;

SCHISTOSOMA MANSONI;

EID: 70449123539     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2009.09.007     Document Type: Letter

References (16)

1. Ismail M., et al. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am. J. Trop. Med. Hyg. 55 (1996) 214-218
2. William S., et al. Stability and reproductive fitness of Schistosoma mansoni isolates with decreased sensitivity to praziquantel. Int. J. Parasitol. 31 (2001) 1093-1100
3. Geisler M., et al. The ABC of auxin transport: the role of p-glycoproteins in plant development. FEBS Lett. 580 (2006) 1094-1102
4. Glavinas H., et al. The role of ABC transporters in drug resistance, metabolism and toxicity. Curr. Drug Deliv. 1 (2004) 27-42
5. James C.E., et al. Drug resistance mechanisms in helminths: is it survival of the fittest?. Trends Parasitol. 25 (2009) 328-335
6. Lage H. ABC-transporters: implications on drug resistance from microorganisms to human cancers. Int. J. Antimicrob. Agents 22 (2003) 188-199
7. Bosch I.B., et al. Two Schistosoma mansoni cDNAs encoding ATP-binding cassette (ABC) family proteins. Mol. Biochem. Parasitol. 65 (1994) 351-356
8. Ambudkar S.V., et al. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 361-398
9. Sato H., et al. Functional visualization of the excretory system of adult Schistosoma mansoni by the fluorescent marker resorufin. Parasitology 125 (2002) 527-535
10. Sato H., et al. Excretion of fluorescent substrates of mammalian multidrug resistance-associated protein (MRP) in the Schistosoma mansoni excretory system. Parasitology 128 (2004) 43-52
11. Messerli S.M., et al. Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility. Mol. Biochem. Parasitol. 167 (2009) 54-59
12. Hayeshi R., et al. The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux. Eur. J. Pharm. Sci. 29 (2006) 70-81
13. Dupuy J., et al. Influence of anthelmintic drugs on P-glycoprotein transport activity in mdr1-LLC-PK1. J. Vet. Pharmacol. Ther. 29 Suppl 1 (2006) 115
14. Kasinathan, R.S. et al. (2009) Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. FASEB J., doi:10.1096/fj.09-137091
15. Callaghan R., et al. P-glycoprotein: so many ways to turn it on. J. Clin. Pharmacol. 48 (2008) 365-378
16. James C.E., et al. Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans. Int. J. Parasitol. 39 (2009) 213-220