Involvement of MAP kinase cascades in Smad7 transcriptional regulation

Biochemical and Biophysical Research Communications

Volumn 289, Issue 2, 2001, Pages 376-381

  Uchida, Keiko ^a   Suzuki, Hitoe ^a   Ohashi, Teiko ^a   Nitta, Kosaku ^a   Yumura, Wako ^a   Nihei, Hiroshi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Gel shift assay; Smad; Smad7 promoter; TGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; SMAD PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HYPEROSMOLALITY; NEGATIVE FEEDBACK; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSCRIPTION REGULATION;

EID: 0035976739     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5984     Document Type: Article

References (16)

1. Identification of Smad7, a TGF-β-inducible antagonist of TGF-β signaling
2. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
3. Blockade of TGF-β signaling in T cells prevents the development of experimental glomerulonephritis
4. Inhibition of transforming growth factor-β/SMAD signaling by the interferon-gamma/STAT pathway
5. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factorβ
6. Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
7. Isolation and characterization of kidney-specific ClC-K1 chloride channel gene promoter
8. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
9. Transcription factor ATF2 regulation by JNK signal transduction pathway
10. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
11. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-β signaling
12. Regulation of Smad7 promoter by direct association with Smad3 and Smad4
13. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
14. Interdependent SMAD and JNK signaling in transforming growth factor-β-mediated transcription
15. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members
16. The role of the Smad3 protein in phorbol ester-induced promoter expression