Trichlorfon predisposes to aneuploidy and interferes with spindle formation in in vitro maturing mouse oocytes

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 564, Issue 2, 2004, Pages 165-178

  Cukurcam, Suna ^a   Sun, Fengyun ^a   Betzendahl, Ilse ^a   Adler, Ilse Dore ^b   Eichenlaub Ritter, Ursula ^a  

^a BIELEFELD UNIVERSITY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Aneuploidy; C banding; Mouse oocytes; Spindle morphology; Trichlorfon

Indexed keywords

ANEUGEN; METRIFONATE;

ANAPHASE; ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL DIVISION; CELL MATURATION; CHROMATID; CHROMOSOME; CHROMOSOME SEGREGATION; CONTROLLED STUDY; FEMALE; GERM CELL; MEIOSIS; METAPHASE; MOUSE; NONHUMAN; OOCYTE; OOCYTE DEVELOPMENT; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ANEUPLOIDY; ANIMALS; CHROMOSOME SEGREGATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MEIOSIS; MICE; MITOTIC SPINDLE APPARATUS; OOCYTES; TRICHLORFON;

MURINAE;

EID: 7044261982     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.08.008     Document Type: Article

References (92)

1. J.M. Parry, A. Al-Obaidly, M. Al-Walhaib, M. Kayani, T. Nabeel, J. Strefford, E.M. Parry, and Spontaneous induced aneuploidy, considerations which may influence chromosome malsegregation Mutat. Res. 504 2002 119 129
2. T. Boveri Zur Frage der Entstehlung maligner Tumoren 1914 Jena Gustave Fischer
3. S.M. Galloway Chromosome aberrations induced in vitro: mechanisms, delayed expression, and intriguing questions Environ. Mol. Mutagen 23 Suppl. 24 1994 44 53
4. D.A. Rew Significance of aneuploidy Br. J. Surg. 81 1994 1416 1422
5. D.K. Griffin The incidence, origin, and etiology of aneuploidy Int. Rev. Cytol. 167 1996 263 296
6. T. Hassold, M. Abruzzo, K. Adkins, D. Griffin, M. Merrill, E. Millie, D. Saker, J. Shen, and M. Zaragoza Human aneuploidy: incidence, origin, and etiology Environ. Mol. Mutagen 28 1996 167 175
7. T. Hassold, and P. Hunt To err (meiotically) is human: the genesis of human aneuploidy Nat. Rev. Genet. 2 2001 280 291
8. U. Eichenlaub-Ritter Parental age-related aneuploidy in human germ cells and offspring: a story of past and present Environ. Mol. Mutagen 28 1996 211 236
9. U. Eichenlaub-Ritter Genetics of oocyte ageing Maturitas 30 1998 143 169
10. U. Eichenlaub-Ritter Ageing and aneuploidy in oocytes Ernst Schering Res Found Workshop 41 2002 111 136
11. A.E. Czeizel, C. Elek, S. Gundy, J. Metneki, E. Nemes, A. Reis, K. Sperling, L. Timar, G. Tusnady, and Z. Viragh Environmental trichlorfon and cluster of congenital abnormalities Lancet 341 1993 539 542
12. E. Reiner, B. Krauthacker, V. Simeon, and M. Skrinjaric-Spoljar Mechanism of inhibition in vitro of mammalian acetylcholinesterase and cholinesterase in solutions of 0,0-dimethyl-2,2,2-trichloro-1-hydroxyethyl phosphonate (Trichlorphon) Biochem. Pharmacol. 24 1975 717 722
13. W. Lorenz Therapeutical experiences in vasomotor rhinitis with special reference to antihistaminics Dtsch Gesundheitsw 10 1955 1679 1686
14. A. Lebrun Preliminary note on the toxicity of an organophosphorus insecticide (dipterex) for man Bull. World Health Organ. 22 1960 579 582
15. M.M. Malagon, S. Garcia-Navarro, A. Ruiz-Navarro, and F. Gracia-Navarro Morphometric evaluation of subcellular changes induced by in vivo TRH treatment in the pituitary gland of Rana perezi: effects on prolactin and thyrotropic cells Cell Tissue Res. 256 1989 391 398
16. J. Van Die The inhibition of serum cholinesterase by 0,0-dimethyl 2,2,2-trichloro-hydroxyethyl phosphate and 0,0-dimethyl 0-2,2-dichlorovinyl phosphate Koninkl. Ned. Akad. Wetenschap Proc. Ser. B 60 1957 227 233
17. R.L. Metcalf, R.B. Fukuto, and R.B. March Toxic action of Dipterex and DDVP to the house fly J. Econ. Entomol. 52 1959 44 49
18. J. Miyamoto Non-enzymatic conversion of Dipterex into DDVP and their inhibitory action on enzymes Botyu-Kagaku. 24 1959 130 137
19. I. Nordgren, M. Bergstrom, B. Holmstedt, and M. Sandoz Transformation and action of metrifonate Arch. Toxicol. 41 1978 31 41
20. M. Hallak, and E. Giacobini Physostigmine, tacrine and metrifonate: the effect of multiple doses on acetylcholine metabolism in rat brain Neuropharmacology 28 1989 199 206
21. P.N. Tariot, W. Pendlebury, and R. Hamill Pisa syndrome without neuroleptic exposure in a patient with dementia of the Alzheimer type: a follow-up report J. Geriatr. Psychiatr. Neurol. 10 1997 130
22. T. van Bao, I. Szabo, P. Ruzicska, and A. Czeizel Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication Humangenetik 24 1974 33 57
23. A.E. Czeizel Phenotypic and cytogenetic studies in self-poisoned patients Mutat. Res. 313 1994 175 181
24. A.T. Doherty, S. Ellard, E.M. Parry, and J.M. Parry A study of the aneugenic activity of trichlorfon detected by centromere-specific probes in human lymphoblastoid cell lines Mutat. Res. 372 1996 221 231
25. A. Mehl, V. Rolseth, S. Gordon, M. Bjoraas, E. Seeberg, and F. Fonnum Brain hypoplasia caused by exposure to trichlorfon and dichlorvos during development can be ascribed to DNA alkylation damage and inhibition of DNA alkyltransferase repair Neurotoxicology 21 2000 165 173
26. Y. Tian, H. Ishikawa, and T. Yamauchi Analysis of cytogenetic and developmental effects on pre-implantation, mid-gestation and near-term mouse embryos after treatment with trichlorfon during zygote stage Mutat. Res. 471 2000 37 44
27. F.Y. Sun, T.E. Schmid, E. Schmid, A. Baumgartner, and I.D. Adler Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells Mutagenesis 15 2000 17 24
28. H. Yin, S. Cukurcam, I. Betzendahl, I.D. Adler, and U. Eichenlaub-Ritter Trichlorfon exposure, spindle aberrations and non-disjunction in mammalian oocytes Chromosoma 107 1998 514 522
29. U. Eichenlaub-Ritter, and I. Betzendahl Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes Mutagenesis 10 1995 477 486
30. U. Eichenlaub-Ritter, and I. Boll Age-related non-disjunction, spindle formation and progression through maturation of mammalian oocytes Prog. Clin. Biol. Res. 318 1989 259 269
31. S. Brunet, A.S. Maria, P. Guillaud, D. Dujardin, J.Z. Kubiak, and B. Maro Kinetochore fibers are not involved in the formation of the first meiotic spindle in mouse oocytes, but control the exit from the first meiotic M phase J. Cell Biol. 146 1999 1 12
32. D. Soewarto, H. Schmiady, and U. Eichenlaub-Ritter Consequences of non-extrusion of the first polar body and control of the sequential segregation of homologues and chromatids in mammalian oocytes Hum. Reprod. 10 1995 2350 2360
33. A.K. Tarkowski An air-drying methods for chromosome preparation from mouse eggs Cytogenetics 5 1966 394 400
34. R. LeMaire-Adkins, K. Radke, and P.A. Hunt Lack of checkpoint control at the metaphase/anaphase transition: a mechanism of meiotic non-disjunction in mammalian females J. Cell Biol. 139 1997 1611 1619
35. G.F. Erickson, and R.A. Sorensen In vitro maturation of mouse oocytes isolated from late, middle, and pre-antral graafian follicles J. Exp. Zool. 190 1974 123 127
36. R.G. Edwards Maturation in vitro of mouse, sheep, cow, pig, rhesus monkey and human ovarian oocytes Nature 208 1965 349 351
37. D.J. Brusick International Commission for Protection Against Environmental Mutagens and Carcinogens. In: Series of Current Issues in Mutagenesis and Carcinogenesis, No. 39 Mutat. Res. 319 1993 243 244
38. W. Dedek, H. Scheufler, and G.W. Fischer The mutagenicity of desmethyltrichlorphone in dominant lethal test on mice (author's translation) Arch. Toxicol. 33 1975 163 168
39. J.W. Allen, J.C. Liang, A.V. Carrano, and R.J. Preston Review of literature on chemical-induced aneuploidy in mammalian male germ cells Mutat. Res. 167 1986 123 137
40. V.L. Dellarco, K.H. Mavournin, and M.D. Waters Aneuploidy Data Review Committee: summary compilation of chemical data base and evaluation of test methodology Mutat. Res. 167 1986 149 169
41. H. Bulsiewicz, L. Rozewicka, H. Januszewska, and J. Bajko Aberrations of meiotic chromosomes induced in mice with insecticides Folia Morphol. (Warsz.) 35 1976 361 368
42. IPCS, Trichlorfon Health and Safety Guide, Health and Safety Guide, No. 66, WHO, Geneva, 1991.
43. F. Sun, I. Betzendahl, Y. Shen, R. Cortvrindt, J. Smitz, and U. Eichenlaub-Ritter Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes Mutagenesis 19 2004 13 25
44. F.J. van der Staay, V.C. Hinz, and B.H. Schmidt Effects of metrifonate, its transformation product dichlorvos, and other organophosphorus and reference cholinesterase inhibitors on Morris water escape behavior in young-adult rats J. Pharmacol. Exp. Ther. 278 1996 697 708
45. C. Morrison, P. Vagnarelli, E. Sonoda, S. Takeda, and W.C. Earnshaw Sister chromatid cohesion and genome stability in vertebrate cells Biochem. Soc. Trans. 31 Part 1 2003 263 265
46. T.S. Kitajima, Y. Miyazaki, M. Yamamoto, and Y. Watanabe Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast EMBO J. 22 2003 5643 5753
47. T.S. Kitajima, S.A. Kawashima, and Y. Watanabe The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis Nature 427 2004 510 517
48. J. Lee, T. Iwai, T. Yokota, and M. Yamashita Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis J. Cell Sci. 116 Part 13 2003 2781 2790
49. U. Eichenlaub-Ritter, E. Vogt, H. Yin, and R. Gosden Spindles, mitochondria and redox potential in ageing oocytes Reprod. Biomed. Online 8 2004 45 58
50. F. Fonnum, and E.A. Lock The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells J. Neurochem. 88 2004 513 531
51. M. Herbert, M. Levasseur, H. Homer, K. Yallop, A. Murdoch, and A. McDougall Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1 Nat. Cell Biol. 2003 5
52. H. Yu Regulation of APC-Cdc20 by the spindle checkpoint Curr. Opin. Cell Biol. 14 2002 706 714
53. N. Steuerwald, J. Cohen, R.J. Herrera, M. Sandalinas, and C.A. Brenner Association between spindle assembly checkpoint expression and maternal age in human oocytes Mol. Hum. Reprod. 7 2001 49 55
54. B.J. Tunquist, P.A. Eyers, L.G. Chen, A.L. Lewellyn, and J.L. Maller Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest J. Cell Biol. 163 2003 1231 1242
55. M. Pakaski, Z. Rakonczay, and P. Kasa Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro Neurochem. Int. 38 2001 219 226
56. M. Pakaski, Z. Rakonczay, I. Fakla, H. Papp, and P. Kasa In vitro effects of metrifonate on neuronal amyloid precursor protein processing and protein kinase C level Brain Res. 863 2000 266 270
57. P. De Sarno, M. Pomponi, E. Giacobini, X.C. Tang, and E. Williams The effect of heptyl-physostigmine, a new cholinesterase inhibitor, on the central cholinergic system of the rat Neurochem. Res. 14 1989 971 977
58. L.S. Katz, and J.K. Marquis Modulation of central muscarinic receptor binding in vitro by ultralow levels of the organophosphate paraoxon Toxicol. Appl. Pharmacol. 101 1989 114 123
59. L.S. Volpe, T.M. Biagioni, and J.K. Marquis In vitro modulation of bovine caudate muscarinic receptor number by organophosphates and carbamates Toxicol. Appl. Pharmacol. 78 1985 226 234
60. Z. Raconczay, and H. Papp Effects of chronic metrifonate treatment on cholinergic enzymes and the blood-brain barrier Neurochem. Int. 9 2001 520 528
61. F. Eusebi, F. Mangia, and L. Alfei Acetylcholine-elicited responses in primary and secondary mammalian oocytes disappear after fertilisation Nature 277 1979 651 653
62. C. Caratsch, F. Eusebi, and A. Salustri Acetylcholine receptors in monkey and rabbit oocytes J. Cell Physiol. 121 1984 415 418
63. F. Eusebi, N. Pasetto, and G. Siracusa Acetylcholine receptors in human oocytes J. Physiol. 346 1984 321 330
64. S. Fritz, K.J. Fohr, S. Boddien, U. Berg, C. Brucker, and A. Mayerhofer Functional and molecular characterization of a muscarinic receptor type and evidence for expression of choline-acetyltransferase and vesicular acetylcholine transporter in human granulosa-luteal cells J. Clin. Endocrinol. Metab. 84 1999 1744 1750
65. S. Fritz, I. Wessler, R. Breitling, W. Rossmanith, S.R. Ojeda, G.A. Dissen, A. Amsterdam, and A. Mayerhofer Expression of muscarinic receptor types in the primate ovary and evidence for non-neuronal acetylcholine synthesis J. Clin. Endocrinol. Metab. 86 2001 349 354
66. M. Li, P. Morley, J.L. Schwartz, J.F. Whitfield, and B.K. Tsang Muscarinic cholinergic stimulation elevates intracellular pH in chicken granulosa cells by a Ca(2+)-dependent, Na(+)-independent mechanism Endocrinology 131 1992 235 239
67. P. Morley, B.K. Tsang, J.F. Whitfield, and J.L. Schwartz The effect of muscarinic cholinergic agonists on intracellular calcium and progesterone production by chicken granulosa cells Endocrinology 130 1992 663 670
68. M.R. Luck Cholinergic stimulation, through muscarinic receptors, of oxytocin and progesterone secretion from bovine granulosa cells undergoing spontaneous luteinization in serum-free culture Endocrinology 126 1990 1256 1263
69. J. Carroll, and K. Swann Spontaneous cytosolic calcium oscillations driven by inositol trisphosphate occur during in vitro maturation of mouse oocytes J. Biol. Chem. 267 1992 11196 11201
70. M.J. Berridge, P.H. Cobbold, and K.S. Cuthbertson Spatial and temporal aspects of cell signalling Philos. Trans. R. Soc. Lond. B: Biol. Sci. 320 1988 325 343
71. M.J. Berridge Inositol trisphosphate and diacylglycerol: two interacting second messengers Annu. Rev. Biochem. 56 1987 159 193
72. 2+ storage organelles in non-muscle cells: heterogeneity and functional assignment Biochim. Biophys. Acta 1055 1990 130 140
73. A. Mayerhofer, N. Dimitrijevic, and L. Kunz The expression and biological role of the non-neuronal cholinergic system in the ovary Life Sci. 72 2003 2039 2045
74. + channel in the ovary: identification, characterization, and functional involvement in steroidogenesis J. Clin. Endocrinol. Metab. 87 2002 5566 5574
75. C.C. Felder Muscarinic acetylcholine receptors: signal transduction through multiple effectors FASEB J. 9 1995 619 625
76. M.P. Caulfield Muscarinic receptors - characterization, coupling and function Pharmacol. Ther. 58 1993 319 379
77. 2+ oscillations via m3/m4 muscarinic receptors in the mouse oocyte Pflugers Arch. 447 2003 321 327
78. G.M. Fuller, and B.R. Brinkley Structure and control of assembly of cytoplasmic microtubules in normal and transformed cells J. Supramol. Struct. 5 1976 497 514
79. E. Nishida, and H. Kumagai Calcium sensitivity of sea urchin tubulin in in vitro assembly and the effects of calcium-dependent regulator (CDR) proteins isolated from sea urchin eggs and porcine brains J. Biochem. (Tokyo) 87 1980 143 151
80. S.A. Berkowitz, and J. Wolff Intrinsic calcium sensitivity of tubulin polymerization. The contributions of temperature, tubulin concentration, and associated proteins J. Biol. Chem. 256 1981 11216 11223
81. K. Sogabe, N.F. Roeser, J.A. Davis, S. Nurko, M.A. Venkatachalam, and J.M. Weinberg Calcium dependence of integrity of the actin cytoskeleton of proximal tubule cell microvilli Am. J. Physiol. 271 2, Part 2 1996 292 303
82. P.T. Tran, P. Joshi, and E.D. Salmon How tubulin subunits are lost from the shortening ends of microtubules J. Struct. Biol. 118 1997 107 118
83. M. Schliwa The role of divalent cations in the regulation of microtubule assembly. In vivo studies on microtubules of the heliozoan axopodium using the ionophore A23187 J. Cell Biol. 70 1976 527 540
84. D.P. Kiehart Studies on the in vivo sensitivity of spindle microtubules to calcium ions and evidence for a vesicular calcium-sequestering system J. Cell Biol. 88 1981 604 617
85. ++-calmodulin causes a localized depolymerization of microtubules J. Cell Biol. 97 1983 1918 1924
86. S. Choudhary, K. Joshi, and K.D. Gill Possible role of enhanced microtubule phosphorylation in dichlorvos induced delayed neurotoxicity in rat Brain Res. 897 2001 60 70
87. S.M. Downs, J. Cottom, and M. Hunzicker-Dunn Protein kinase C and meiotic regulation in isolated mouse oocytes Mol. Reprod. Dev. 58 2001 101 115
88. M.M. Viveiros, M. O'Brien, K. Wigglesworth, and J.J. Eppig Characterization of protein kinase C-delta in mouse oocytes throughout meiotic maturation and following egg activation Biol. Reprod. 69 2003 1494 1499
89. Y.Q. Su, and J.J. Eppig Evidence that multifunctional calcium/calmodulin-dependent protein kinase II (CaM KII) participates in the meiotic maturation of mouse oocytes Mol. Reprod. Dev. 61 2002 560 569
90. F.J. van der Staay, V.C. Hinz, and B.H. Schmidt Effects of metrifonate, its transformation product dichlorvos, and other organophosphorus and reference cholinesterase inhibitors on Morris water escape behavior in young-adult rats J. Pharmacol. Exp. Ther. 278 1996 697 708
91. W. Dedek Guanine N7-alkylation in mice in vivo by metrifonate - discussion of possible genotoxic risks in mammals Acta Pharamacol. Toxicol. 49 suppl V 1981 40 50
92. W. Dedek, and H. Schwartz Studien zur applikation und zum metabolismus von Trichlorphon in der veterinärmedizin Atompraxis 12 1966 603