The influence of age at onset and gender on the HLA-DQA1, DQB1 association in Chinese children with insulin dependent diabetes mellitus

Human Immunology

Volumn 60, Issue 11, 1999, Pages 1131-1137

  Chen, Bai Hsiun ^a   Chiang, Cheng Hua ^a   Lin, Shiu Ru ^a   Chao, Mei Gyn ^a   Tsai, Shih Tse ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Age at onset; DQB1; Gender; HLA DQA1; Insulin dependent diabetes mellitus; PCR SSP

Indexed keywords

HLA DQ ANTIGEN;

ARTICLE; CHILD; CHINESE; CONTROLLED STUDY; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HLA SYSTEM; HUMAN; IMMUNOGENETICS; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADOLESCENT; AGE OF ONSET; ALLELES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHINA; DIABETES MELLITUS, TYPE 1; FEMALE; GENE FREQUENCY; HAPLOTYPES; HLA-DQ ANTIGENS; HUMANS; INFANT; MALE; SEX CHARACTERISTICS;

EID: 0345476897     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(99)00106-8     Document Type: Article

References (40)

1. Hirayama K., Matsushita S., Kikushi I., Iuchi M., Ohta M., Sasazuki T. HLA-DQ is epistatic to HLA-DR in controling the immune response to shistosomal antigen in humans. Nature. 327:1987;426.
2. Sasazuki T., Kikuchi I., Hirayama K., Matsushita S., Ohta N., Nishimura Y. HLA-linked immune suppression in humans. Immunology. 2:(suppl):1989;21.
3. Altmann D.M., Dansom S.D., Marsh S.G.E. What is the basis for HLA-DQ associations with autoimmune disease? Immunol Today. 12:1991;267.
4. Todd J.A., Acha-Orben H., Bell J.I., et al. A molecular basis for MHC class II-associated autoimmunity. Science. 240:1988;1003.
5. Nishimura Y, Thorsby E, Roningen KS, et al: General organization and overview of the disease component. In Tsuji K, Aizawa M, Sasazuki T, et al (eds): HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. Vol. I. Oxford, Oxford University Press, 1992:693.
6. Gepts W. The pathology of the pancreas in human diabetes. Andreani D., DiMario U., Federin K.F., Heding L.G. Immunology in Diabetes. 1984;21 Kimptom, London.
7. Eisenbarth G.S. Type I diabetes mellitus a chronic autoimmune disease . N Eng J Med. 314:1986;1360.
8. Svejgaad A., Platz P., Ryder L.P. Joint report Insulin-dependent diabetes mellitus . Terasaki P. Histocompatibility Testing 1980. 1980;638 UCLA Tissue Typing Laboratory, Los Angeles.
9. Svejgaad A., Platz P., Ryder L.P. HLA and disease 1982-a survey. Immunol Rev. 70:1983;193.
10. Bertrams J., Baur M.P. Disease report insulin-dependent diabetes mellitus . Albert E., Baur M., Mayr W. Histocompatibility Testing 1984. 1984;348 Springer-Verlag, Berlin.
11. Thomson G. HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet. 36:1984;1309.
12. Tiwari JL, Terasaki PI: Juvenile diabetes mellitus (insulin-dependent). In HLA and Disease Association. New York, Springer-Verlag, 1985:185.
13. Thomson G., Robinson W.P., Kuhner M.K., et al. Genetic heterogeneity, modes of inheritance, and risk estimate for a joint study of Caucasians with insulin-dependent diabetes mellitus. Am J Hum Genet. 43:1988;799.
14. Owerbach D., Lernmark A., Platz P., et al. HLA-D region beta chain DNA endonuclease fragment differ between HLA-DR identical healthy and insulin-dependent diabetic individuals. Nature. 303:1983;815.
15. Arnheim N., Strange C., Eflich H. Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragment and human diease studies of the HLA class II loci . Proc Natl Acad Sci USA. 1985 82:1983;6970.
16. Cohe-Haguenauer O., Robbins E., Massart C.C., et al. A systematic study of HLA class II-beta DNA restriction fragment in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA. 82:1985;3335.
17. Bohme J., Carlsson B., Wallin J., et al. Only one DQ-beta restriction fragments pattern of each DR specificity is associated with insulin-dependent diabetes mellitus. J Immunol. 137:1986;941.
18. Festenstein H., Awad J., Hitman G.A., et al. New HLA DNA polymorphism associated with autoimmune disease. Nature. 322:1986;64.
19. Nepom B.S., Palmer J., Kin S.J., Hanson J.A., Holbeck S.L., Nepom G.T. Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med. 164:1986;345.
20. Schreuder G.M.T., Tilanus G.L., Bontrop R.E., et al. HLA- DQ polymorphism associated with resistence to type I diabetes detected with monoclonal antibodies, isoelectric point differences and restriction fragment length polymorphism. J Exp Med. 164:1986;938.
21. Tai B.D., Boyle A.L. DR4 and susceptibility to type I diabetes mellitus discrimination of high riskand low risk DR4 hoplotypes on the basis of TA10 typing . Tissue Antigens. 28:1986;65.
22. Todd J.A., Mijovic C., Fletcher J., Jenkins D., Bradwell A.R., Barnett A.H. Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature. 338:1989;587.
23. Hu C.Y., Allen M., Chuang L.M., Lin B.J., Gyllensten U. Association of insulin-dependent diabetes mellitus in Taiwan with HLA class II DQB1 and DRB1 alleles. Hum Immunol. 38:1993;105.
24. Huang H.S., Huang M.J., Huang C.C., Huang B.Y., Wang P.W., Lin J.D. A strong association of HLA-DR 3/4 heterozygotes with insulin-dependent diabetes mellitus among Chinese in Taiwan. J Formosan Med Assoc. 87:1988;1.
25. Huang H.S., Huang M.J., Huang C.C. Assessment of the association of HLA-DR 3/4 heterozygous with diabetes mellitus and non-diabetes mellitus. J Formosan Med Assoc. 91:1992;233.
26. Ju L.Y., San Y.P., Semana G., et al. Aspartic acid at position 57 of the HLA-DQB chain in insulin-dependent diabetes mellitus an association with one DRw9-DQw9subtype in the Chinese population . Tissue Antigen. 37:1991;218.
27. Olerup O., Aldener A., Fogdell A. HLAa-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours. Tissue Antigens. 41:1993;119.
28. Caillat-Zucman S., Garchon H.J., Timsit J., Assan R., Boitard C., Djilali-Saiah I., Bougneres P., Bach J.F. Age dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest. 90:1992;2242.
29. Chan S.H., Thai A.C., Lin Y.N., Wee G.B. Influence of gender and age at onset on the HLA association in Chinese with insulin-dependent diabetes mellitus. Hum Immuol. 44:1995;175.
30. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 29:1979;1039.
31. Huang H.S., Peng J.T., She J.Y., Zhang L.P., Chao C.C.K., Liu K.H., She J.X. HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population. Hum Immuol. 44:1995;210.
32. Chuang L.M., Jou T.S., Wu H.P., Chang H.M., Ysai W.Y., Hsieh R.P., Chen K.H., Lin B.J., Tai T.Y. HLA DQA! Genotypes and its interaction with HLA DQB1 in Chinese IDDM living in Taiwan. Proce Nat Sci Council, ROC. 19:1995;73.
33. Aparicio J.M.R., Wakisaka A., Takada A., Matsuura N., Aizawa M. HLAa-Dq system and insulin-dependent diabetes mellitus in Japanese does it contribute to the development of IDDM as it does in Causasians? Immunogenetics. 28:1988;240.
34. Awata T., Kuzuya T., Matsuda A., Iwamoto Y., Kanazawa Y. Genetic analysis of HLAa class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects. Diabetologica. 35:1992;419.
35. Ikegami H., Kawaguchi Y., Yamato E., Kuwata S., Takunaga K., Noma Y., Shima K., Ogihara T. Analysis by polymerase chain reaction of histocompatibility leukocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 75:1992;1381.
36. Thorsby E., Roningen K.S. Particular HLA-DQ molecules play a dominant role in determing susceptibility or resistance to type 1 (insulin dependent) diabetes mellitus. Diabetologica. 36:1993;371.
37. Sugihara S., Sakamaki T., Konda S., Murata A., Wataki K., Kobayashi Y., Minamitani K., Miyamoto S., Sasaki N., Niimi H. Association of HLA-DR, DddQ genotype with different beta-cell functions at IDDM diagnosis in Japanese children. Diabetes. 46:1997;1893.
38. Yasunaga S, Kimura A, Hamaguchi K, Ronningen KS, Sasazuki T: different contribution of HLAa-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). 47: 37, 1996.
39. Tai B.D., Harrison L.C., Drummond B.P., Stewart V., Varney M.D., Honeyman M.C. HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum Immunol. 42:1995;116.
40. Penny M.A., Jenkins D., Mijovic C.H., et al. Susceptibility in IDDM in a Chinese population. Diabetes. 41:1991;914.