Relative bioavailability of cyclosporine A-loaded hydroxypropyl methylcellulose phthalate nanoparticles for oral administration in rats

Yaoxue Xuebao

Volumn 39, Issue 6, 2004, Pages 463-466

  Wang, Xue Qing ^a   Dai, Jun Dong ^a   Zhang, Qiang ^a   Zhang, Tao ^b   Xia, Gui Min ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b North China Pharmaceutical Corporation   (China)

Author keywords

Cyclosporine A; Hydroxypropyl methylcellulose phthalate; Nanoparticle; Relative bioavailability

Indexed keywords

CYCLOSPORIN A; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NANOPARTICLE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; MALE; METHYLCELLULOSE; NANOSTRUCTURES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 7044249338     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Desai MP, Labhasetwar V, Amidon GL, et al. Gastrointestinal of biodegradable microparticles [J]. Pharm Res, 1996,13(12):1838-1845.
2. Molpeceres J, Guzman M, Aberturas MR, et al. Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement [J]. J Pharm Sci, 1996,85(2):206-213.
3. El-Shabouri MH. Positively charged nanoparticles for improving the oral bioavailability of cyclosporine-A [J]. Int J Pharm, 2002,249(1-2):101-108.
4. Jaeghere FD, Allémann E, Kubel F, et al. Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: effect of the particle size and nutritional state [J]. J Controlled Release, 2000,68(3):291-298.
5. Wang XQ, Zhang T, He Y, et al. Study on preparation conditions for polylactide nanoparticles loaded cyclosporines A and its oral bioavailability in rats [J]. Acta Pharm Sin, 2004,39(1):68-71.
6. Eldridge JH, Hammond CJ, Meulbroek JA, et al. Controlled vaccine release in the gut-associated lymphoid tissues I: orally administered biodegradable microspheres target the Peyer's patches [J]. J Controlled Release, 1990,11(2):205-214.