Study on preparation conditions for polylactide nanoparticles loaded cyclosporine A and its oral bioavailability in rats

Yaoxue Xuebao

Volumn 39, Issue 1, 2004, Pages 68-71

  Wang, Xue Qing ^a   Zhang, Tao ^b   He, Ying ^a   Zhang, Liang ^a   Zhang, Qiang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b NONE

Author keywords

Bioavailability; Cyclosporine A; Nanoparticles; Polylactide; Solvent nosolvent method

Indexed keywords

ACETONE; CYCLOSPORIN A; SOLVENT; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; POLYESTER; POLYLACTIDE;

ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; DRUG ABSORPTION; DRUG ELIMINATION; NANOPARTICLE; NONHUMAN; RAT; ANIMAL; DELAYED RELEASE FORMULATION; MALE; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; RANDOMIZATION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; DELAYED-ACTION PREPARATIONS; IMMUNOSUPPRESSIVE AGENTS; MALE; NANOTECHNOLOGY; POLYESTERS; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 3242799015     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. R) [J]. Drugs, 1995,50(5):924-941.
2. Lavelle EC, Sharif S, Thomas NW, et al. The importance of gastrointestinal uptake of particles in the design of oral delivery systems [J]. Adv Drug Deliv Rev, 1995,18(1):5-17.
3. Desai MP, Labhasetwar V, Amidon GL, et al. Gastrointestinal of biodegradable microparticles [J]. Pharm Res, 1996,13(12):1838-1845.
4. The Pharmacopoeia Commission of P. R. of China. Pharmacopoeia of the Peoples' Republic of China [S]. Part II. Beijing: Chemical Industry Press, 2000. Appendix 202.
5. Li HS, Ye GQ, Zhao JL, et al. Improved high performance liquid chromatographic determination of cyclosporine A in whole blood samples of rat and rabbit [J]. West China J Pharm Sci, 1999,14(2):89-92.