Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice

European Journal of Neuroscience

Volumn 16, Issue 12, 2002, Pages 2317-2323

  Ma, Dan ^a   Allen, Nicholas D ^b   Van Bergen, Yfke C H ^a   Jones, Camilla M E ^a   Baum, Michael J ^c   Keverne, E Barry ^a   Brennan, Peter A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c Boston University   (United States)

Author keywords

Anosmia; Nitroreductase; Olfactory epithelium; Vomeronasal organ

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; NITROREDUCTASE; OLFACTORY MARKER PROTEIN; PHEROMONE; PRODRUG; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; CELL KILLING; CONTROLLED STUDY; CONVALESCENCE; CYTOTOXICITY; FEMALE; FUNCTION TEST; HABITUATION; MALE; MOUSE; NERVE INJURY; NEUROANATOMY; NONHUMAN; OLFACTORY DISCRIMINATION; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY DYSFUNCTION; SENSORY NERVE CELL; TRANSGENIC MOUSE; VOMERONASAL ORGAN;

ANIMALS; AZIRIDINES; CELL COUNT; CELL DEATH; EPITHELIAL CELLS; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROTOXINS; NITROREDUCTASES; OLFACTORY MARKER PROTEIN; OLFACTORY RECEPTOR NEURONS; PREGNANCY; SEX ATTRACTANTS; VOMERONASAL ORGAN;

EID: 0036925539     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02303.x     Document Type: Article

References (22)

1. Brennan, P.A. (1999) Bruce effect. In Knobil, E. & Neill, J.D (eds), Encyclopedia of Reproduction. Academic Press, San Diego, pp. 433-438.
2. Brown, R.E., Singh, P.B. & Roser, B. (1987) The major histocompatibility complex and the chemosensory recognition of individuality in rats. Physiol. Behav., 40, 65-73.
3. Buiakova, O.I., Baker, H., Scott, J.W., Farbman, A., Kream, R., Grillo, M., Franzen, L., Richman, M., Davis, L.M., Abbondanzo, S., Stewart, C.L. & Margolis, F.L. (1996) Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Proc. Natl. Acad. Sci. USA, 93, 9858-9863.
4. Burd, G.D. (1993) Morphological study of the effects of intranasal zinc sulfate irrigation on the mouse olfactory epithelium and olfactory bulb. Microsc. Res. Techn., 24, 195-213.
5. Cui, W., Gusterson, B. & Clark, A.J. (1999) Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway. Gene Ther., 6, 764-770.
6. Cummings, D.M., Emge, D.K., Small, S.L. & Margolis, F.L. (2000) Pattern of olfactory bulb innervation returns after recovery from reversible peripheral deafferentation. J. Comp. Neurol., 421, 362-373.
7. Døving, K.B. & Trotier, D. (1998) Structure and function of the vomeronasal organ. J. Exp. Biol., 21, 2913-2925.
8. 4 irrigation on behavior, biochemistry and morphology. Brain Res., 140, 271-285.
9. Humphries, R.E., Robertson, D.H.L., Beynon, R.J. & Hurst, J.L. (1999) Unravelling the chemical basis of competitive scent marking in house mice. Anim. Behav., 58, 1177-1190.
10. Isles, A.R., Ma, D., Milsom, C., Skynner, M., Cui, W., Clark, J., Keverne, E.B. & Allen, M. (2001) Conditional ablation of neurons in transgenic mice. J. Neurobiol., 47, 183-193.
11. Johnston, R.A. (1998) Pheromones, the vomeronasal system, and communication. Ann. N.Y. Acad. Sci., 855, 333-348.
12. Kishimoto, J., Keverne, E.B., Hardwick, J. & Emson, P. (1993) Localization of nitric oxide sythase in the mouse olfactory and vomeronasal system: A histochemical, immunological and in situ hybridization study. Eur. J. Neurosci., 5, 1684-1694.
13. Knox, R.J., Friedlos, F. & Boland, M.P. (1993) The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). Cancer Metastasis Rev., 12, 195-212.
14. Lloyd-Thomas, A. & Keverne, E.B. (1982) Role of the brain and accessory olfactory system in the block to pregnancy in mice. Neuroscience, 7, 907-913.
15. Lu, X-C.M. & Slotnick, B.M. (1998) Olfaction in rats with extensive lesions of the olfactory bulbs: Implications for odor coding. Neuroscience, 84, 849-866.
16. Meredith, M. (1994) Chronic recording of vomeronasal pump activation in awake behaving hamsters. Physiol. Behav., 56, 345-354.
17. Meredith, M. (1998) Vomeronasal, olfactory, hormonal convergence in the brain. Ann. N. Y. Acad. Sci., 855, 349-361.
18. Pitha, J. (1985) Amorphous water soluble derivatives of cyclodextrins: Non-toxic dissolution enhancing excipients. J. Pharm. Sci., 74, 987-990.
19. Schwob, J.E., Youngentob, S.L. & Mezza, R.C. (1995) Reconstitution of the rat olfactory epithelium after methyl bromide-induced lesion. J. Comp. Neurol., 359, 15-37.
20. Stowers, L., Holy, T.E., Meister, M., Dulac, C. & Koentges, G. (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science, 295, 1493-1500.
21. Sundberg, H., Døving, K., Novikov, S. & Ursin, H. (1982) A method for studying responses and habituation to odors in rats. Behav. Neural Biol., 34, 113-119.
22. Youngentob, S.L., Schwob, J.E., Sheehe, P.R. & Youngentob, L.M. (1997) Odorant threshold following methyl bromide-induced lesions of the olfactory epithelium. Physiol. Behav., 62, 1241-1252.