Treatment of Fistulizing Inflammatory Bowel Disease

Gastroenterology Clinics of North America

Volumn 38, Issue 4, 2009, Pages 595-610

  Schwartz, David A ^a   Maltz, Brad E ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Abscess; Anti TNF; Biologic agents; Crohn disease; Fistula; Inflammatory bowel disease; Perianal; Treatment

Indexed keywords

ADALIMUMAB; ANTIBIOTIC AGENT; AST 120; AZATHIOPRINE; CERTOLIZUMAB PEGOL; CIPROFLOXACIN; CYCLOSPORIN; IMMUNOMODULATING AGENT; INFLIXIMAB; MERCAPTOPURINE; METRONIDAZOLE; NATALIZUMAB; PLACEBO; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; TUMOR NECROSIS FACTOR ANTIBODY;

ANUS FISTULA; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIARRHEA; DIGESTIVE SYSTEM FISTULA; DIGITAL RECTAL EXAMINATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; DRUG TOLERABILITY; ENDOSCOPIC ECHOGRAPHY; ENTERITIS; ENTEROCUTANEOUS FISTULA; FISTULOGRAPHY; GLOSSITIS; HEADACHE; HUMAN; HYPERBARIC OXYGEN; INSOMNIA; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; RASH; RECTOVAGINAL FISTULA; REMISSION; REVIEW; SENSORY NEUROPATHY; SIDE EFFECT; TASTE DISORDER; TOTAL PARENTERAL NUTRITION; TREMOR;

CROHN DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL FISTULA; MAGNETIC RESONANCE IMAGING; RECTAL FISTULA; TREATMENT OUTCOME;

EID: 70350771267     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gtc.2009.07.009     Document Type: Review

References (82)

1. Schwartz D.A., Loftus Jr. E.V., Tremaine W.J., et al. The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota. Gastroenterology 122 (2002) 875-880
2. Hellers G., Bergstrand O., Ewerth S., et al. Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 21 (1980) 525-527
3. Tang L.Y., Rawsthorne P., and Bernstein C.N. Are perineal and luminal fistulas associated in Crohn's disease? A population-based study. Clin Gastroenterol Hepatol 4 (2006) 1130-1134
4. Michelassi F., Stella M., Balestracci T., et al. Incidence, diagnosis, and treatment of enteric and colorectal fistulae in patients with Crohn's disease. Ann Surg 218 (1993) 660-666
5. Hughes L.E. Clinical classification of perianal Crohn's disease. Dis Colon Rectum 35 (1992) 928-932
6. Hughes L.E. Surgical pathology and management of anorectal Crohn's disease. J R Soc Med 71 (1978) 644-651
7. Parks A.G., Gordon P.H., and Hardcastle J.D. A classification of fistula in ano. Br J Surg 63 (1976) 1-12
8. American Gastroenterological Association medical position statement: perianal Crohn' disease. Gastroenterology 125 (2003) 1503-1507
9. Makowiec F., Jehle E.C., Becker H.D., et al. Perianal abscess in Crohn's disease. Dis Colon Rectum 40 (1997) 443-450
10. Williamson P.R., Hellinger M.D., Larach S.W., et al. Twenty-year review of the surgical management of perianal Crohn's disease. Dis Colon Rectum 38 (1995) 389-392
11. Regueiro M., and Mardini H. Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 9 (2003) 98-103
12. Bayer I., and Gordon P.H. Selected operative management of fistula in ano in Crohn's disease. Dis Colon Rectum 37 (1994) 760-765
13. Van Beers B., Grandin C., Kartheuser A., et al. MRI of complicated anal fistulae: comparison with digital examination. J Comput Assist Tomogr 18 (1994) 87-90
14. Glass R.E., Ritchie J.K., Lennard-Jones J.E., et al. Internal fistulas in Crohn's disease. Dis Colon Rectum 28 (1985) 557-561
15. Fazio V.W., Wilk P., Turnbull Jr. R.B., et al. The dilemma of Crohn's disease: ileosigmoidal fistula complicating Crohn's disease. Dis Colon Rectum 20 (1977) 381-386
16. Kuijpers H.C., and Schulpen T. Fistulography for fistulain ano. Is it useful?. Dis Colon Rectum 28 (1985) 103-104
17. Weisman R.I., Orsay C.P., Pearl R.K., et al. The role of fistulography in fistula in ano. Report of five cases. Dis Colon Rectum 34 (1991) 181-184
18. Schratter-Sehn A.U., Lochs H., Vogelsang H., et al. Endoscopic ultrasonography versus computed tomography in the differential diagnosis of perianorectal complications in Crohn's disease. Endoscopy 25 (1993) 582-586
19. Van Outryve M.J., Pelckmans P.A., Michielsen P.P., et al. Value of transrectal ultrasonography in Crohn's disease. Gastroenterology 101 (1991) 1171-1177
20. Fishman E.K., Wolf E.J., Jones B., et al. CT evaluation of Crohn's disease: effect on patient management. AJR Am J Roentgenol 148 (1987) 537-540
21. Berliner L., Redmond P., Purow E., et al. Computed tomography in Crohn's disease. Am J Gastroenterol 77 (1982) 548-553
22. Goldberg H.I., Gore R.M., Margulis A.R., et al. Computed tomography in the evaluation of Crohn disease. AJR Am J Roentgenol 140 (1983) 277-282
23. Lunniss P.J., Barker P.G., Sultan A.H., et al. Magnetic resonance imaging of fistula in ano. Dis Colon Rectum 37 (1994) 708-718
24. Lunniss P.J., Armstrong P., Barker P.G., et al. Magnetic resonance imaging of anal fistulae. Lancet 340 (1992) 394-396
25. Barker P.G., Lunniss P.J., Armstrong P., et al. Magnetic resonance imaging of fistula in ano: technique, interpretation, and accuracy. Clin Radiol 49 (1994) 7-13
26. Haggett P.J., Moore N.R., Shearman J.D., et al. Pelvic and perineal complications of Crohn's disease: assessment using magnetic resonance imaging. Gut 36 (1995) 407-410
27. Rasul I., Wilson S.R., MacRae H., et al. Clinical and radiological responses after infliximab treatment for perianal fistulizing Crohn's disease. Am J Gastroenterol 99 (2004) 82-88
28. Schwartz D.A., Wiersema M.J., Dudiak K.M., et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas. Gastroenterology 121 (2001) 1064-1072
29. Orsoni P., Barthet M., Portier F., et al. Prospective comparison of endosonography, magnetic resonance imaging, and surgical findings in anorectal fistula and abscess complicating Crohn's disease. Br J Surg 86 (1999) 360-364
30. Tio T.L., Mulder C.J., Wijers O.B., et al. Endosonography of perianal and pericolorectal fistula and/or abscess in Crohn's disease. Gastrointest Endosc 36 (1990) 331-336
31. Van Assche G., Vanbeckevoort D., Bielen D., et al. Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease. Am J Gastroenterol 98 (2003) 332-339
32. van Bodegraven A.A., Sloots C.E., Felt-Bersma R.J., et al. Endosonographic evidence of persistence of Crohn's disease-associated fistulas after infliximab treatment, irrespective of clinical response. Dis Colon Rectum 45 (2002) 39-45 [discussion: 45-6]
33. Bell S.J., Halligan S., Windsor A.C., et al. Response of fistulating Crohn's disease to infliximab treatment assessed by magnetic resonance imaging. Aliment Pharmacol Ther 17 (2003) 387-393
34. Brandt L.J., Bernstein L.H., Boley S.J., et al. Metronidazole therapy for perineal Crohn's disease: a follow-up study. Gastroenterology 83 (1982) 383-387
35. Present D.H., Korelitz B.I., Wisch N., et al. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 302 (1980) 981-987
36. Bernstein L.H., Frank M.S., Brandt L.J., et al. Healing of perineal Crohn's disease with metronidazole. Gastroenterology 79 (1980) 599
37. Thia K.T., Mahadevan U., Feagan B.G., et al. Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn's disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis 15 (2009) 17-24
38. Pearson D.C., May G.R., Fick G.H., et al. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med 123 (1995) 132-142
39. Dejaco C., Harrer M., Waldhoer T., et al. Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. Aliment Pharmacol Ther 18 (2003) 1113-1120
40. Gonzalez-Lama Y., Abreu L., Vera M.I., et al. Long-term oral tacrolimus therapy in refractory to infliximab fistulizing Crohn's disease: a pilot study. Inflamm Bowel Dis 11 (2005) 8-15
41. Fukushima T., Sugita A., Masuzawa S., et al. Effects of cyclosporin A on active Crohn's disease. Gastroenterol Jpn 24 (1989) 12-15
42. Lichtiger S. Cyclosporine therapy in inflammatory bowel disease: open-label experience. Mt Sinai J Med 57 (1990) 315-319
43. Hanauer S.B., and Smith M.B. Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A. Am J Gastroenterol 88 (1993) 646-649
44. Mahadevan U., and Sandborn W.J. Diagnosis and management of pouchitis. Gastroenterology 124 (2003) 1636-1650
45. Schroder O., Blumenstein I., Schulte-Bockholt A., et al. Combining infliximab and methotrexate in fistulizing Crohn's disease resistant or intolerant to azathioprine. Aliment Pharmacol Ther 19 (2004) 295-301
46. Schreiber S., Thomsen O.O., Hanauer S., et al. Cimzia is effective in the treatment of Crohn's disease patients with open fistulas. Inflamm Bowel Dis 14 (2008) S1
47. Topstad D.R., Panaccione R., Heine J.A., et al. Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn's disease: a single center experience. Dis Colon Rectum 46 (2003) 577-583
48. Ghosh S., Goldin E., Gordon F.H., et al. Natalizumab for active Crohn's disease. N Engl J Med 348 (2003) 24-32
49. Sandborn W.J., Colombel J.F., Enns R., et al. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 353 (2005) 1912-1925
50. Targan S.R., Feagan B.G., Fedorak R.N., et al. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology 132 (2007) 1672-1683
51. Lavy A., Weisz G., Adir Y., et al. Hyperbaric oxygen for perianal Crohn's disease. J Clin Gastroenterol 19 (1994) 202-205
52. Sandborn W.J., Fazio V.W., Feagan B.G., et al. AGA technical review on perianal Crohn's disease. Gastroenterology 125 (2003) 1508-1530
53. Fukuda Y., Takazoe M., Sugita A., et al. Oral spherical adsorptive carbon for the treatment of intractable anal fistulas in Crohn's disease: a multicenter, randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 103 (2008) 1721-1729
54. Spradlin N., Wise P., Herline A., et al. A randomized prospective trial of endoscopic ulrasound (EUS) to guide combination medical and surgical treatment for Crohn's perianal fistulas. Am J Gastroenterol 103 (2008) 2527-2535
55. Schwartz D.A., White C.M., Wise P.E., et al. Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn's perianal fistulas. Inflamm Bowel Dis 11 (2005) 727-732
56. Spradlin N.M., Wise P.E., Herline A.J., et al. A randomized prospective trial of endoscopic ultrasound to guide combination medical and surgical treatment for Crohn's perianal fistulas. Am J Gastroenterol 103 (2008) 2527-2535
57. Tougeron D., Savoye G., Savoye-Collet C., et al. Predicting factors of fistula healing and clinical remission after infliximab-based combined therapy for perianal fistulizing Crohn's disease. Dig Dis Sci 54 (2009) 1746-1752
58. Fichera A., and Michelassi F. Surgical treatment of Crohn's disease. J Gastrointest Surg 11 (2007) 791-803
59. Williams J.G., Farrands P.A., Williams A.B., et al. The treatment of anal fistula: ACPGBI position statement. Colorectal Dis 9 Suppl 4 (2007) 18-50
60. Fuhrman G.M., and Larach S.W. Experience with perirectal fistulas in patients with Crohn's disease. Dis Colon Rectum 32 (1989) 847-848
61. Present D.H., Rutgeerts P., Targan S., et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340 (1999) 1398-1405
62. Sands B.E., Anderson F.H., Bernstein C.N., et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 350 (2004) 876-885
63. van der Hagen S.J., Baeten C.G., Soeters P.B., et al. Staged mucosal advancement flap for the treatment of complex anal fistulas: pretreatment with noncutting setons and in case of recurrent multiple abscesses a diverting stoma. Colorectal Dis 7 (2005) 513-518
64. Levien D.H., Surrell J., and Mazier W.P. Surgical treatment of anorectal fistula in patients with Crohn's disease. Surg Gynecol Obstet 169 (1989) 133-136
65. Makowiec F., Jehle E.C., and Starlinger M. Clinical course of perianal fistulas in Crohn's disease. Gut 37 (1995) 696-701
66. Hyman N. Endoanal advancement flap repair for complex anorectal fistulas. Am J Surg 178 (1999) 337-340
67. Abel M.E., Chiu Y.S., Russell T.R., et al. Autologous fibrin glue in the treatment of rectovaginal and complex fistulas. Dis Colon Rectum 36 (1993) 447-449
68. Cintron J.R., Park J.J., Orsay C.P., et al. Repair of fistulas in ano using fibrin adhesive: long-term follow-up. Dis Colon Rectum 43 (2000) 944-949 [discussion: 949-50]
69. Lindsey I., Smilgin-Humphreys M.M., Cunningham C., et al. A randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistula. Dis Colon Rectum 45 (2002) 1608-1615
70. Singer M., Cintron J., Nelson R., et al. Treatment of fistulas in ano with fibrin sealant in combination with intra-adhesive antibiotics and/or surgical closure of the internal fistula opening. Dis Colon Rectum 48 (2005) 799-808
71. Schwandner O., Stadler F., Dietl O., et al. Initial experience on efficacy in closure of cryptoglandular and Crohn's transsphincteric fistulas by the use of the anal fistula plug. Int J Colorectal Dis 23 (2008) 319-324
72. Ky A.J., Sylla P., Steinhagen R., et al. Collagen fistula plug for the treatment of anal fistulas. Dis Colon Rectum 51 (2008) 838-843
73. Practice parameters for treatment of fistula in ano-supporting documentation. The Standards Practice Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum 39 (1996) 1363-1372
74. Yamamoto T., Bain I.M., Allan R.N., et al. Persistent perineal sinus after proctocolectomy for Crohn's disease. Dis Colon Rectum 42 (1999) 96-101
75. Galandiuk S., Kimberling J., Al-Mishlab T.G., et al. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg 241 (2005) 796-801 [discussion:801-2]
76. Singh B., Mc C.M.N.J., Jewell D.P., et al. Perianal Crohn's disease. Br J Surg 91 (2004) 801-814
77. Bauer J.J., Sher M.E., Jaffin H., et al. Transvaginal approach for repair of rectovaginal fistulae complicating Crohn's disease. Ann Surg 213 (1991) 151-158
78. Songne K., Scotte M., Lubrano J., et al. Treatment of anovaginal or rectovaginal fistulas with modified Martius graft. Colorectal Dis 9 (2007) 653-656
79. Sands B.E., Blank M.A., Patel K., et al. Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2 (2004) 912-920
80. Schreiber S., Colombel J.F., Panes J., et al. Recent-onset Crohn's disease shows higher remission rates and durability of response to treatment with subcutaneous monthly certolizumab pegol: results from the analysis of the PRECISE 2 phase III study [abstract]. Gut 55 (2006) A131
81. Schreiber S., and Colombel J.F. Early Crohn's disease shows high levels of remission to therapy with adalimumab: sub-analysis of CHARM [abstract]. Gastroenterology 132 Suppl 2 (2007) A985
82. Sandborn W.J., Present D.H., Isaacs K.L., et al. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology 125 (2003) 380-388