Bone morphogenetic protein 15 expression in human ovaries from fetuses, girls, and women

Fertility and Sterility

Volumn 92, Issue 5, 2009, Pages 1666-1673

  Margulis, Sima ^a   Abir, Ronit ^a   Felz, Carmela ^a   Nitke, Shmuel ^a   Krissi, Haim ^a   Fisch, Benjamin ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

BMP 15; human ovaries; immunohistochemistry; in situ hybridization; primordial follicles

Indexed keywords

BONE MORPHOGENETIC PROTEIN 15; MESSENGER RNA; PARAFFIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; FETUS; GESTATIONAL AGE; GRANULOSA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LAPAROSCOPY; OOCYTE; OUTCOME ASSESSMENT; PRECAMBRIAN; PREGNANCY TERMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SCHOOL CHILD; STROMA CELL; TERTIARY HEALTH CARE;

ADOLESCENT; ADULT; AGING; BONE MORPHOGENETIC PROTEIN 15; CELL COUNT; CHILD; CHILD, PRESCHOOL; FEMALE; FETUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HUMANS; OVARIAN FOLLICLE; OVARY; YOUNG ADULT;

EID: 70350749631     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.08.119     Document Type: Article

References (38)

1. Shimasaki S., Moore R.K., Otsuka F., and Erickson G.F. The bone morphogenetic protein system in mammalian reproduction. Endocr Rev 25 (2004) 72-101
2. Ten Dijke P., Korchynskyi O., Valdimarsdottir G., and Goumans M.J. Controlling cell fate by bone morphogenetic protein receptors. Mol Cell Endocrinol 211 (2003) 105-113
3. Dube J.L., Wang P., Elvin J., Lyons K.M., Celeste A.J., and Matzuk M.M. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol Endocrinol 12 (1998) 1809-1817
4. Moore R.K., and Shimasaki S. Molecular biology and physiological role of the oocyte factor, BMP-15. Mol Cell Endocrinol 234 (2005) 67-73
5. Moore R.K., Otsuka F., and Shimasaki S. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J Biol Chem 278 (2003) 304-310
6. Juengel J.L., Bodensteiner K.J., Heath D.A., Hudson N.L., Moeller C.L., Smith P., et al. Physiology of GDF9 and BMP15 signaling molecules. Anim Reprod Sci 82-83 (2004) 447-460
7. Abir R., Ben-Haroush A., Melamed N., Felz C., Krissi H., and Fisch B. Expression of bone morphogenetic proteins 4 and 7 and their receptors IA, IB, and II in human ovaries from fetuses and adults. Fertil Steril 89 (2008) 1430-1440
8. Nohe A., Keating E., Knaus P., and Petersen N.O. Signal transduction of bone morphogenetic protein receptors. Cell Signal 16 (2004) 291-299
9. Edwards S.J., Reader K.L., Lun S., Western A., Lawrence S., McNatty K.P., et al. The cooperative effect of growth and differentiation factor-9 and bone morphogenetic protein (BMP)-15 on granulosa cell function is modulated primarily through BMP receptor II. Endocrinol 149 (2008) 1026-1030
10. Gosden R.G. Oocyte development throughout life. In: Grudzinshes J.G., and Yovici J.L. (Eds). Gametes-the oocyte (1995), Cambridge University Press, Cambridge, U.K 119-149
11. Gougeon A. Regulations of ovarian follicular development in primates: facts and hypotheses. Endocrinol Rev 17 (1996) 121-155
12. I) for the Inverdale prolificacy gene located on the X chromosome. Biol Reprod 46 (1992) 636-640
13. I) are devoid of secondary and tertiary follicles but contain many abnormal structures. Biol Reprod 49 (1993) 895-907
14. Galloway S.M., McNatty K.P., Cambridge L.M., Laitinen M.P.E., Juengel J.L., Jokiranta T.S., et al. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Genet 25 (2000) 279-283
15. Hanrahan J.P., Gregan S.M., Mulsant P., Mullen M., Davis G.H., Powell R., et al. Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod 70 (2004) 900-909
16. Di Pasquale E., Beck-Peccoz P., and Persani L. Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Am J Hum Genet 75 (2004) 106-111
17. Juengel J.L., Hudson N.L., Heath D.A., Smith P., Reader K.L., Lawrence S.B., et al. Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep. Biol Reprod 67 (2002) 1777-1789
18. Laitinen M., Vuojolainen K., Jaatinen R., Ketola I., Aaltonen J., Lehtonen E., et al. A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis. Mech Dev 78 (1998) 135-140
19. Sadeu J.C., Adriaenssens T., and Simtz J. Expression of growth differentiation factor 9, bone morphogenetic protein 15 and anti-Müllerian hormone in cultured mouse primary follicles. Reprod 136 (2008) 195-203
20. Jaatinen R., Laitinen M., Vuojolainen K., Aaltonen J., Louhio H., Heikinheimo K., et al. Localization of growth differentiation factor-9 (GDF-9) mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B. Mol Cell Endocrinol 156 (1999) 189-193
21. Eckery D.C., Whale L.J., Lawrence S.B., Wylde K.A., McNatty K.P., and Juengel J.L. Expression of mRNA encoding growth differentiation factor 9 and bone morphogenetic protein 15 during follicular formation and growth in a marsupial, the brushtail possum (Trichosurus vulpecula). Mol Cell Endocrinol 192 (2002) 115-126
22. Aaltonen J., Laitinen M.P., Vuojolainen K., Jaatinen R., Horelli-Kuitunen N., Seppa L., et al. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis. J Clin Endocrinol Metab 84 (1999) 2744-2750
23. Teixeira Filho F.L., Baracat E.C., Lee T.H., Suh C.S., Matsui M., Chang R.J., et al. Aberrant expression of growth differentiation factor-9 in oocytes of women with polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 1337-1344
24. Silva J.R.V., Van Den Hurk R., Van Tol H.T.A., Roelen B.A.J., and Figueiredo J.R. Expression of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and BMP receptors in the ovaries of goats. Mol Reprod Dev 70 (2005) 11-19
25. Mery L., Lefevre A., Benchaib M., Demirci B., Salle B., Guerin J.-F., et al. Follicular growth in vitro: detection of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during in vitro culture of ovine cortical slices. Mol Reprod Dev 74 (2007) 767-774
26. Biron-Shental T., Fisch B., Van Den Hurk R., Felz C., Feldberg D., and Abir R. Survival of frozen-thawed human ovarian fetal follicles in long-term organ culture. Fertil Steril 81 (2004) 716-719
27. Feigin E., Freud E., Fisch B., Orvieto R., Kravarusic D., Avrahami G., et al. Fertility preservation in female adolescents with malignancies. In: Moorland M.T. (Ed). Cancer in female adolescents (2008), Nova Science Publishers, Hauppauge, NY chapter 3, 103-38
28. Abir R., Nitke S., Ben-Haroush A., and Fisch B. In vitro maturation of human primordial ovarian follicles-Clinical significance, progress and methods for growth evaluation. Histol Histopathol 21 (2006) 887-898
29. Alberts B., Johnson A., Lewis J., Raff M., Roberts K., and Walter P. How cells read the genome: from DNA to protein. In: Alberts B., Johnson A., Lewis J., Raff M., Roberts K., and Walter P. (Eds). Molecular biology of the cell. 4th ed. (2002), Garland Science, New York, NY 299-374
30. Yan C., Wang P., DeMayo J., DeMayo F.J., Elvin J.A., Carino C., et al. Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol 15 (2001) 854-866
31. Galloway S.M., Gregan S.M., Wilson T., McNatty K.P., Juengel J.L., Ritvos O., et al. BMP15 mutations and ovarian function. Mol Cell Endocrinol 191 (2002) 15-18
32. I) on the X chromosome that influences ovulation rate. Biol Reprod 48 (1993) 1150-1156
33. Demeestere I., Simon P., Emiliani S., Delbaere A., and Englert Y. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin's disease. Oncologist 12 (2007) 1437-1442
34. Otsuka F., and Shimasaki S. A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis. Proc Natl Acad Sci U S A 99 (2002) 8060-8065
35. Otsuka F., Yamamoto S., Erickson G.F., and Shimasaki S. Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. J Biol Chem 276 (2001) 11387-11392
36. Otsuka F., and Shimasaki S. A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes. Endocrinology 143 (2002) 4938-4941
37. Huang H.-J., Wu J.C., Su P., Zhirnov O., and Miller W.L. A novel role for bone morphogenetic proteins in the synthesis of follicle-stimulating hormone. Endocrinology 142 (2001) 2275-2283
38. Otsuka F., Moore R.K., Iemura S., Ueno N., and Shimasaki S. Follistatin inhibits the function of the oocyte-derived factor BMP-15. Biochem Biophys Res Commun 289 (2001) 961-966