Localization of growth differentiation factor-9 (GDF-9) mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B

Molecular and Cellular Endocrinology

Volumn 156, Issue 1-2, 1999, Pages 189-193

  Jaatinen, Risto ^a   Laitinen, Mika P ^a   Vuojolainen, Kaisa ^a   Aaltonen, Johanna ^a   Louhio, Henna ^b   Heikinheimo, Kristiina ^c   Lehtonen, Eero ^a   Ritvos, Olli ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Infertility Clinic   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

BMP 15; Bone morphogenetic protein; Folliculogenesis; GDF 9; GDF 9B; Growth differentiation factor; Oocyte; Ovary; Protein localization

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COMPLEMENTARY DNA; GROWTH FACTOR; MESSENGER RNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; OVARY; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

AGING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GROWTH SUBSTANCES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; OOCYTES; OVARIAN FOLLICLE; OVARY; PROTEIN SORTING SIGNALS; RATS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032860525     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(99)00100-8     Document Type: Article

References (16)

1. Bodensteiner K.J., Clay C.M., Moeller C.L., Sawyer H.R. Molecular cloning of the ovine growth/differentiation factor-9 gene and expression of growth/differentiation factor-9 in ovine and bovine ovaries. Biol. Reprod. 60:1999;381-386.
2. Dong J., Albertini D.F., Nishimori K., Kumar T.R., Lu N., Matzuk M.M. Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature. 383:1996;531-535.
3. Dube J.L., Wang P., Elvin J., Lyons K.M., Celeste A.J., Matzuk M.M. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes. Mol. Endocrinol. 12:1998;1809-1817.
4. Elvin J.A., Matzuk M.M. Mouse models of ovarian failure. Rev. Reprod. 3:1998;183-195.
5. Erämaa M., Heikinheimo K., Tuuri T., Hildén K., Ritvos O. Inhibin/activin subunit mRNA expression in human granulosa-luteal cells. Mol. Cell. Endocrinol. 92:1993;R15-R20.
6. Fitzpatrick S.L., Sindoni D.M., Shughrue P.J., Lane M.V., Merchenthaler I.J., Frail D.E. Expression of growth differentiation factor-9 messenger ribonucleic acid in ovarian and nonovarian rodent and human tissues. Endocrinology. 139:1998;2571-2578.
7. Gougeon A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr. Rev. 17:1996;121-155.
8. Hayashi M., McGee E.A., Min G., Klein C., Rose U.M., van Duin M., Hsueh A.J. Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles. Endocrinology. 140:1999;1236-1244.
9. Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., Wilson D.B. Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology. 138:1997;3505-3514.
10. Hsu S.Y., Kaipia A., McGee E., Lomeli M., Hsueh A.J. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. USA. 94:1997;12401-12406.
11. Laitinen M., Rutanen E.-M., Ritvos O. Expression of c-kit ligand messenger ribonucleic acids in human ovaries and regulation of their steady state levels by gonadotropins in cultured granulosa-luteal cells. Endocrinology. 136:1995;4407-4414.
12. Laitinen M., Vuojolainen K., Jaatinen R., Ketola I., Aaltonen J., Lehtonen E., Heikinheimo M., Ritvos O. A novel growth differentiation factor-9 (GDF-9) related factor is co-expressed with GDF-9 in mouse oocytes during folliculogenesis. Mech. Dev. 78:1998;135-140.
13. McGrath S.A., Esquela A.F., Lee S.J. Oocyte-specific expression of growth/differentiation factor-9. Mol. Endocrinol. 9:1995;131-136.
14. McPherron A.C., Lee S.J. GDF-3 and GDF-9: two new members of the transforming growth factor-ß superfamily containing a novel pattern of cysteines. J. Biol. Chem. 268:1993;3444-3449.
15. Nielsen H., Engelbrecht J., Brunak S., von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng. 10:1997;1-6.
16. Sidis Y., Fujiwara T., Leykin L., Isaacson K., Toth T., Schneyer A.L. Characterization of inhibin/activin subunit, activin receptor, and follistatin mRNA in human and mouse oocytes: evidence for activin's paracrine signaling from granulosa cells to oocytes. Biol. Reprod. 59:1998;807-812.