Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor β on mRNA stability and translatability

BMC Genetics

Volumn 10, Issue , 2009, Pages 55-

  Putnik, Milica ^a   Zhao, Chunyan ^a   Gustafsson, Jan Åke ^a   Dahlman Wright, Karin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR BETA; MESSENGER RNA; DNA;

3' UNTRANSLATED REGION; ARTICLE; BREAST CARCINOMA; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; PLASMID; PROMOTER REGION; RNA STABILITY; RNA TRANSLATION; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; BREAST TUMOR; DNA SEQUENCE; EXON; FEMALE; GENETIC PREDISPOSITION; GENETICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ALLELES; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA, NEOPLASM; ESTROGEN RECEPTOR BETA; EXONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA STABILITY; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

EID: 70350743244     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-10-55     Document Type: Article

References (46)

1. Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, Maggi A, Muramatsu M, Parker MG, Gustafsson JA. International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev 2006, 58:773-81. 10.1124/pr.58.4.8, 17132854.
2. Herynk MH, Fuqua SA. Estrogen receptor mutations in human disease. Endocr Rev 2004, 25:869-98. 10.1210/er.2003-0010, 15583021.
3. Murphy LC, Watson P. Steroid receptors in human breast tumorigenesis and breast cancer progression. Biomed Pharmacother 2002, 56:65-77. 10.1016/S0753-3322(01)00157-3, 12000137.
4. Speirs V. Oestrogen receptor beta in breast cancer: good, bad or still too early to tell?. J Pathol 2002, 197:143-7. 10.1002/path.1072, 12015736.
5. Zhao C, Dahlman-Wright K, Gustafsson JA. Estrogen receptor beta: an overview and update. Nucl Recept Signal 2008, 6:e003. 2254331, 18301783.
6. Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene 2003, 22(48):7600-6. 10.1038/sj.onc.1207100, 14576822.
7. Li LC, Yeh CC, Nojima D, Dahiya R. Cloning and characterization of human estrogen receptor beta promoter. Biochem Biophys Res Commun 2000, 275(2):682-9. 10.1006/bbrc.2000.3363, 10964723.
8. SNP database. , http://snpper.chip.org/
9. Rosenkranz K, Hinney A, Ziegler A, Hermann H, Fichter M, Mayer H, Siegfried W, Young JK, Remschmidt H, Hebebrand J. Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. J Clin Endocrinol Metab 1998, 83:4524-7. 10.1210/jc.83.12.4524, 9851804.
10. Nilsson M, Naessen S, Dahlman I, Linden Hirschberg A, Gustafsson JA, Dahlman-Wright K. Association of estrogen receptor beta gene polymorphisms with bulimic disease in women. Mol Psychiatry 2004, 9:28-34. 10.1038/sj.mp.4001402, 14699439.
11. Reimann M, Vafeiadou K, Hall WL, Dierkes J, Nilsson M, Dahlman-Wright K, Ferrari M, Huebner U, Hallund J, Bugel S, Branca F, Williams CM, Koebnick C. Evidence for associations between common polymorphisms of estrogen receptor beta gene with homocysteine and nitric oxide. Climacteric 2006, 9:215-23. 10.1080/13697130600733758, 16766435.
12. Silvestri S, Thomsen AB, Gozzini A, Bagger Y, Christiansen C, Brandi ML. Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?. Menopause 2006, 13:451-61. 10.1097/01.gme.0000182804.14385.a2, 16735942.
13. Sundarrajan C, Liao WX, Roy AC, Ng SC. Association between estrogen receptor-beta gene polymorphisms and ovulatory dysfunctions in patients with menstrual disorders. J Clin Endocrinol Metab 2001, 86:135-9. 10.1210/jc.86.1.135, 11231990.
14. Kim JJ, Choi YM, Choung SH, Yoon SH, Lee GH, Moon SY. Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome. Fertil Steril. 2009, 19185861.
15. Westberg L, Hakansson A, Melke J, Shahabi HN, Nilsson S, Buervenich S, Carmine A, Ahlberg J, Grundell MB, Schulhof B, Klingborg K, Holmberg B, Sydow O, Olson L, Johnels EB, Eriksson E, Nissbrandt H. Association between the estrogen receptor beta gene and age of onset of Parkinson's disease. Psychoneuroendocrinology 2004, 29:993-8. 10.1016/j.psyneuen.2003.08.010, 15219649.
16. Kisiel B, Bednarczuk T, Kostrzewa G, Kosinska J, Miskiewicz P, Plazinska MT, Bar-Andziak E, Krolicki L, Krajewski P, Ploski R. Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease. Clin Endocrinol (Oxf) 2008, 68:429-34.
17. Maruyama A, Nakayama T, Sato N, Mizutani Y, Furuya K, Yamamoto T. Association study using single nucleotide polymorphisms in the estrogen receptor beta (ESR2) gene for preeclampsia. Hypertens Res 2004, 27:903-9. 10.1291/hypres.27.903, 15894829.
18. Forsti A, Zhao C, Israelsson E, Dahlman-Wright K, Gustafsson JA, Hemminki K. Polymorphisms in the estrogen receptor beta gene and risk of breast cancer: no association. Breast Cancer Res Treat 2003, 79:409-13. 10.1023/A:1024020609833, 12846425.
19. Maguire P, Margolin S, Skoglund J, Sun XF, Gustafsson JA, Borresen-Dale AL, Lindblom A. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. Breast Cancer Res Treat 2005, 94:145-52. 10.1007/s10549-005-7697-7, 16261413.
20. Georgopoulos NA, Adonakis GL, Fotopoulos A, Koika V, Spinos N, Saltamavros A, Keramopoulos A, Koukouras D, Decavalas G, Kourounis GS. Estrogen receptor polymorphisms in tamoxifen-treated women with breast cancer. Gynecol Endocrinol 2006, 22:185-9. 10.1080/09513590600645767, 16723304.
21. Gold B, Kalush F, Bergeron J, Scott K, Mitra N, Wilson K, Ellis N, Huang H, Chen M, Lippert R, Halldorsson BV, Woodworth B, White T, Clark AG, Parl FF, Broder S, Dean M, Offit K. Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res 2004, 64:8891-900. 10.1158/0008-5472.CAN-04-1256, 15604249.
22. Cox DG, Bretsky P, Kraft P, Pharoah P, Albanes D, Altshuler D, Amiano P, Berglund G, Boeing H, Buring J, Burtt N, Calle EE, Canzian F, Chanock S, Clavel-Chapelon F, Colditz GA, Feigelson HS, Haiman CA, Hankinson SE, Hirschhorn J, Henderson BE, Hoover R, Hunter DJ, Kaaks R, Kolonel L, LeMarchand L, Lund E, Palli D, Peeters PH, Pike MC, Riboli E, Stram DO, Thun M, Tjonneland A, Travis RC, Trichopoulos D, Yeager M. Breast and Prostate Cancer Cohort Consortium Haplotypes of the estrogen receptor beta gene and breast cancer risk. Int J Cancer 2008, 122(2):387-92. 10.1002/ijc.23127, 17935138.
23. Hughes TA. Regulation of gene expression by alternative untranslated regions. Trends Genet 2006, 22:119-22. 10.1016/j.tig.2006.01.001, 16430990.
24. de Moor CH, Meijer H, Lissenden S. Mechanisms of translational control by the 3' UTR in development and differentiation. Semin Cell Dev Biol 2005, 16:49-58. 10.1016/j.semcdb.2004.11.007, 15659339.
25. Mazumder B, Seshadri V, Fox PL. Translational control by the 3'-UTR: the ends specify the means. Trends Biochem Sci 2003, 28(2):91-8. 10.1016/S0968-0004(03)00002-1, 12575997.
26. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001, 107(4):451-64. 10.1016/S0092-8674(01)00578-5, 11719186.
27. Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell 2005, 20(6):905-915. 16364915, 10.1016/j.molcel.2005.10.031.
28. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136(2):215-33. 10.1016/j.cell.2009.01.002, 19167326.
29. Zhao C, Lam EW, Sunters A, Enmark E, De Bella MT, Coombes RC, Gustafsson JA, Dahlman-Wright K. Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene 2003, 22(48):7600-6. 10.1038/sj.onc.1207100, 14576822.
30. Sugiura H, Toyama T, Hara Y, Zhang Z, Kobayashi S, Fujii Y, Iwase H, Yamashita H. Expression of estrogen receptor beta wild-type and its variant ERbetacx/beta2 is correlated with better prognosis in breast cancer. Jpn J Clin Oncol 2007, 37(11):820-8. 10.1093/jjco/hym114, 17932113.
31. Hartman J, Ström A, Gustafsson JA. Estrogen receptor beta in breast cancer--diagnostic and therapeutic implications. Steroids 2009, 74(8):635-41. 10.1016/j.steroids.2009.02.005, 19463683.
32. Macrogen DNA Sequencing Service. , http://dna.macrogen.com/eng/
33. Kahlert S, Nuedling S, van Eickels M, Vetter H, Meyer R, Grohe C. Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J Biol Chem 2000, 275:18447-53. 10.1074/jbc.M910345199, 10749889.
34. Vivacqua A, Bonofiglio D, Albanito L, Madeo A, Rago V, Carpino A, Musti AM, Picard D, Ando S, Maggiolini M. 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30. Mol Pharmacol 2006, 70:1414-23. 10.1124/mol.106.026344, 16835357.
35. Wang J, Pitarque M, Ingelman-Sundberg M. 3'-UTR polymorphism in the human CYP2A6 gene affects mRNA stability and enzyme expression. Biochem Biophys Res Commun 2006, 340:491-7. 10.1016/j.bbrc.2005.12.035, 16378601.
36. Pastinen T, Sladek R, Gurd S, Sammak A, Ge B, Lepage P, Lavergne K, Villeneuve A, Gaudin T, Brändström H, Beck A, Verner A, Kingsley J, Harmsen E, Labuda D, Morgan K, Vohl MC, Naumova AK, Sinnett D, Hudson TJ. A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics 2004, 16(2):184-93.
37. Popowski K, Sperker B, Kroemer HK, John U, Laule M, Stangl K, Cascorbi I. Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene. Pharmacogenetics 2003, 13:445-51. 10.1097/00008571-200308000-00002, 12893982.
38. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003, 31(13):3406-15. 10.1093/nar/gkg595, 169194, 12824337.
39. Nilsson M, Dahlman I, Jiao H, Gustafsson JA, Arner P, Dahlman-Wright K. Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study. BMC Med Genet 2007, 8:73. 10.1186/1471-2350-8-73, 2238734, 18053221.
40. Ichikawa S, Koller DL, Peacock M, Johnson ML, Lai D, Hui SL, Johnston CC, Foroud TM, Econs MJ. Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women. J Clin Endocrinol Metab 2005, 90:5921-7. 10.1210/jc.2004-2253, 1948071, 16118344.
41. Lee GH, Kim SH, Choi YM, Suh CS, Kim JG, Moon SY. Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis. Fertil Steril 2007, 88:785-8. 10.1016/j.fertnstert.2006.12.032, 17336962.
42. miRNA database. , http://microrna.sanger.ac.uk/sequences/
43. Rexrode KM, Ridker PM, Hegener HH, Buring JE, Manson JE, Zee RY. Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women. Clin Chem 2007, 53(10):1749-56. 10.1373/clinchem.2007.091454, 2085372, 17702854.
44. Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S. Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. Cancer Sci 2009, 100(5):927-33. 10.1111/j.1349-7006.2009.01118.x, 19298602.
45. Database of common gene variations in the Japanese population. , http://snp.ims.u-tokyo.ac.jp/
46. Dresner-Pollak R, Kinnar T, Friedlander Y, Sharon N, Rosenmann H, Pollak A. Estrogen receptor beta gene variant is associated with vascular dementia in elderly women. Genet Test Mol Biomarkers 2009, 13(3):339-42. 10.1089/gtmb.2008.0129, 19473078.