Autologous chondrocyte implantation to repair knee cartilage injury: Ultrastructural evaluation at 2 years and long-term follow-up including muscle strength measurements

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 17, Issue 11, 2009, Pages 1278-1288

  Løken, Sverre ^a,b   Ludvigsen, Tom C ^a   Høysveen, Turid ^d   Holm, Inger ^c   Engebretsen, Lars ^a,b   Reinholt, Finn P ^c  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d Norwegian School of Sport Medicine   (Norway)

Author keywords

Articular cartilage; Autologous chondrocyte implantation; Chondrocytes; Electron; Histology; Knee; Microscopy; Muscle strength; Surgery

Indexed keywords

EID: 70350738104     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-009-0854-5     Document Type: Article

References (49)

1. Abdelhadi M, Ericzon BG, Hultenby K, Sjoden G, Reinholt FP, Nordenstrom J (2002) Structural skeletal impairment induced by immunosuppressive therapy in rats: cyclosporine A vs tacrolimus. Transpl Int 15:180-187.
2. Aroen A, Loken S, Heir S, Alvik E, Ekeland A, Granlund OG, Engebretsen L (2004) Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med 32:211-215.
3. Barber-Westin SD, Noyes FR, McCloskey JW (1999) Rigorous statistical reliability, validity, and responsiveness testing of the Cincinnati knee rating system in 350 subjects with uninjured, injured, or anterior cruciate ligament-reconstructed knees. Am J Sports Med 27:402-416.
4. Bartlett W, Gooding CR, Carrington RW, Briggs TW, Skinner JA, Bentley G (2005) The role of the Short Form 36 Health Survey in autologous chondrocyte implantation. Knee 12:281-285.
5. Bartlett W, Skinner JA, Gooding CR, Carrington RWJ, Flanagan AM, Briggs TWR, Bentley G (2005) Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective randomised study. J Bone Joint Surg Br 87:640-645.
6. Bentley G, Biant LC, Carrington RWJ, Akmal M, Goldberg A, Williams AM, Skinner JA, Pringle J (2003) A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 85:223-230.
7. Benya PD, Shaffer JD (1982) Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30:215-224.
8. Berman AT, Bosacco SJ, Israelite C (1991) Evaluation of total knee arthroplasty using isokinetic testing. Clin Orthop Relat Res 271:106-113.
9. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331:889-895.
10. Brittberg M, Winalski CS (2003) Evaluation of cartilage injuries and repair. J Bone Joint Surg Am 85:58-69.
11. Browne JE, Anderson AF, Arciero R, Mandelbaum B, Moseley JB Jr, Micheli LJ, Fu F, Erggelet C (2005) Clinical outcome of autologous chondrocyte implantation at 5years in US subjects. Clin Orthop Relat Res 436:237-245.
12. Brun P, Dickinson SC, Zavan B, Cortivo R, Hollander AP, Abatangelo G (2008) Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation. Arthritis Res Ther 10:R132.
13. Drobnic M, Kregar-Velikonja N, Radosavljevic D, Gorensek M, Koritnik B, Malicev E, Wozniak G, Jeras M, Knezevic M (2002) The outcome of autologous chondrocyte transplantation treatment of cartilage lesions in the knee. Cell Mol Biol Lett 7:361-363.
14. Eitzen I, Risberg MA, Holm I (2009) Preoperative quadriceps strength is a significant predictor of knee function two years after anterior cruciate ligament reconstruction. Br J Sports Med 43:371-376.
15. Erggelet C, Steinwachs MR, Reichelt A (2000) The operative treatment of full thickness cartilage defects in the knee joint with autologous chondrocyte transplantation. Saudi Med J 21:715-721.
16. Fu FH, Zurakowski D, Browne JE, Mandelbaum B, Erggelet C, Moseley JB Jr, Anderson AF, Micheli LJ (2005) Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up. Am J Sports Med 33:1658-1666.
17. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-394.
18. Henderson I, Francisco R, Oakes B, Cameron J (2005) Autologous chondrocyte implantation for treatment of focal chondral defects of the knee-a clinical, arthroscopic, MRI and histologic evaluation at 2years. Knee 12:209-216.
19. Henderson I, Lavigne P, Valenzuela H, Oakes B (2007) Autologous chondrocyte implantation: superior biologic properties of hyaline cartilage repairs. Clin Orthop Relat Res 455:253-261.
20. Holm I, Fosdahl MA, Friis A, Risberg MA, Myklebust G, Steen H (2004) Effect of neuromuscular training on proprioception, balance, muscle strength, and lower limb function in female team handball players. Clin J Sport Med 14:88-94.
21. Horas U, Pelinkovic D, Herr G, Aigner T, Schnettler R (2003) Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint: a prospective, comparative trial. J Bone Joint Surg Am 85:185-192.
22. Hunziker EB (2002) Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10:432-463.
23. Hyllested JL, Veje K, Ostergaard K (2002) Histochemical studies of the extracellular matrix of human articular cartilage-a review. Osteoarthritis Cartilage 10:333-343.
24. International Cartilage Repair Society (1998) Cartilage repair assessment. ICRS Newsletter, Spring.
25. Jakobsen RB, Engebretsen L, Slauterbeck JR (2005) An analysis of the quality of cartilage repair studies. J Bone Joint Surg Am 87:2232-2239.
26. Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O (2007) A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am 89:2105-2112.
27. Knutsen G, Engebretsen L, Ludvigsen TC, Drogset JO, Grontvedt T, Solheim E, Strand T, Roberts S, Isaksen V, Johansen O (2004) Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am 86:455-464.
28. Krishnan SP, Skinner JA, Bartlett W, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2006) Who is the ideal candidate for autologous chondrocyte implantation? J Bone Joint Surg Br 88:61-64.
29. Krishnan SP, Skinner JA, Carrington RW, Flanagan AM, Briggs TW, Bentley G (2006) Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee: two- to seven-year results. J Bone Joint Surg Br 88:203-205.
30. Lindahl A, Brittberg M, Peterson L (2001) Health economics benefits following autologous chondrocyte transplantation for patients with focal chondral lesions of the knee. Knee Surg Sports Traumatol Arthrosc 9:358-363.
31. Loge JH, Kaasa S (1998) Short Form 36 (SF-36) Health Survey: normative data from the general Norwegian population. Scand J Soc Med 26:250-258.
32. Marcacci M, Berruto M, Brocchetta D, Delcogliano A, Ghinelli D, Gobbi A, Kon E, Pederzini L, Rosa D, Sacchetti GL, Stefani G, Zanasi S (2005) Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 435:96-105.
33. Micheli LJ, Browne JE, Erggelet C, Fu F, Mandelbaum B, Moseley JB, Zurakowski D (2001) Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up. Clin J Sport Med 11:223-228.
34. Moriya T, Wada Y, Watanabe A, Sasho T, Nakagawa K, Mainil-Varlet P, Moriya H (2007) Evaluation of reparative cartilage after autologous chondrocyte implantation for osteochondritis dissecans: histology, biochemistry, and MR imaging. J Orthop Sci 12:265-273.
35. Munirah S, Samsudin OC, Chen HC, Salmah SH, Aminuddin BS, Ruszymah BH (2007) Articular cartilage restoration in load-bearing osteochondral defects by implantation of autologous chondrocyte-fibrin constructs: an experimental study in sheep. J Bone Joint Surg Br 89:1099-1109.
36. Outerbridge RE (1961) The etiology of chondromalacia patellae. J Bone Joint Surg Br 43:752-757.
37. Peterson L, Minas T, Brittberg M, Lindahl A (2003) Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am 85:17-24.
38. Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A (2000) Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374:212-234.
39. Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A (2002) Autologous chondrocyte transplantation: biomechanics and long-term durability. Am J Sports Med 30:2-12.
40. Ramstad VE, Franzen A, Heinegard D, Wendel M, Reinholt FP (2003) Ultrastructural distribution of osteoadherin in rat bone shows a pattern similar to that of bone sialoprotein. Calcif Tissue Int 72:57-64.
41. Risberg MA, Holm I, Steen H, Eriksson J, Ekeland A (1999) The effect of knee bracing after anterior cruciate ligament reconstruction. A prospective, randomized study with two years' follow-up. Am J Sports Med 27:76-83.
42. Saris DB, Vanlauwe J, Victor J, Haspl M, Bohnsack M, Fortems Y, Vandekerckhove B, Almqvist KF, Claes T, Handelberg F, Lagae K, van der BJ, Vandenneucker H, Yang KG, Jelic M, Verdonk R, Veulemans N, Bellemans J, Luyten FP (2008) Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36:235-246.
43. Schnabel M, Marlovits S, Eckhoff G, Fichtel I, Gotzen L, Vecsei V, Schlegel J (2002) Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthritis Cartilage 10:62-70.
44. Shahdadfar A, Loken S, Dahl JA, Tunheim SH, Collas P, Reinholt FP, Engebretsen L, Brinchmann JE (2008) Persistence of collagen type II synthesis and secretion in rapidly proliferating human articular chondrocytes in vitro. Tissue Eng Part A 14:1999-2007.
45. Sharma A, Wood LD, Richardson JB, Roberts S, Kuiper NJ (2007) Glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage. Arthritis Res Ther 9:R79.
46. Shelbourne KD, Jari S, Gray T (2003) Outcome of untreated traumatic articular cartilage defects of the knee: a natural history study. J Bone Joint Surg Am 85-A(Suppl 2):8-16.
47. Tins BJ, McCall IW, Takahashi T, Cassar-Pullicino V, Roberts S, Ashton B, Richardson J (2005) Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1-year follow-up. Radiology 234:501-508.
48. Ware JE Jr, Sherbourne CD (1992) The MOS 36-item Short-Form Health Survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473-483.
49. Zheng MH, Willers C, Kirilak L, Yates P, Xu J, Wood D, Shimmin A (2007) Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment. Tissue Eng 13:737-746.