Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia

European Journal of Clinical Investigation

Volumn 34, Issue 5, 2004, Pages 335-341

  Pirro, M ^a   Schillaci, G ^a   Savarese, G ^a   Gemelli, F ^a   Vaudo, G ^a   Siepi, D ^a   Bagaglia, F ^a   Mannarino, E ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Abdominal fat; Arterial stiffness; C reactive protein; Hypercholesterolaemia; Pulse wave velocity

Indexed keywords

C REACTIVE PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ANTHROPOMETRY; ARTERY COMPLIANCE; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; INFLAMMATION; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OBESITY; PRIORITY JOURNAL; PULSE WAVE; SYSTOLIC BLOOD PRESSURE;

ABDOMEN; ADIPOSE TISSUE; AORTA; ARTERIES; ARTERIOSCLEROSIS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BODY CONSTITUTION; BODY MASS INDEX; C-REACTIVE PROTEIN; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; INFLAMMATION; MALE; MIDDLE AGED; RISK FACTORS;

EID: 2942519273     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2004.01345.x     Document Type: Article

References (29)

1. Lind L. Lipids and endothelium-dependent vasodilation - a review. Lipids 2002;37:1-15.
2. Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356, 222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986;256:2823-8.
3. Castelli WP, Garrison RJ, Wilson PWF, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels. JAMA 1986;256:2835-8.
4. Evans M, Roberts A, Rees A. The future direction of cholesterol-lowering therapy. Curr Opin Lipidol 2002;13:663-9.
5. Stokes KY, Cooper D, Tailor A, Granger DN. Hypercholesterolemia promotes inflammation and microvascular dysfunction, role of nitric oxide and superoxide. Free Radic Biol Med 2002;33:1026-36.
6. Scalia R, Appel JZ 3rd, Lefer AM. Leukocyte-endothelium interaction during the early stages of hypercholesterolemia in the rabbit. P-selectin, ICAM-1, and VCAM-1. Arterioscler Thromb Vasc Biol 1998;18:1093-100.
7. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation 1998;97:2007-11.
8. Lehmann ED, Hopkins KD, Gosling RG. Aortic compliance measurements using Doppler ultrasound: in vivo biochemical correlates. Ultrasound Med Biol 1993;19:683-710.
9. Cameron JD, Jennings GL, Dart AM. The relationship between arterial compliance, age, blood pressure and serum lipid levels. J Hypertens 1995;13:1718-23.
10. Toikka JO, Niemi P, Ahotupa M, Niinikoski H, Viikari JS, Ronnemaa T et al. Large-artery elastic properties in young men: relationships to serum lipoproteins and oxidized low-density lipoproteins. Arterioscler Thromb Vasc Biol 1999;19:436-41.
11. Hopkins KD, Lehmann ED, Gosling RG, Parker JR, Sonksen PH. Biochemical correlates of aortic distensibility in vivo in normal subjects. Clin Sci (Lond) 1993;84:593-7.
12. Wilkinson IB, Prasad K, Hall IR, Thomas A, MacCallum H, Webb DJ et al. Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol 2002;39:1005-11.
13. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001;37:1236-41.
14. Kontopoulos AG, Athyros VG, Pehlivanidis AN, Demitriadis DS, Papageorgiou AA, Boudoulas H. Long-term treatment effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients. Curr Med Res Opin 2003;19:22-7.
15. Ferrier KE, Muhlmann MH, Baguet JP, Cameron JD, Jennings GL, Dart AM et al. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. J Am Coll Cardiol 2002;39:1020-5.
16. Kool M, Lustermans F, Kragten H, Struijker-Boudier H, Hoeks A, Reneman R et al. Does lowering of cholesterol levels influence functional properties of large arteries? Eur J Clin Pharmacol 1995;48:217-23.
17. Raison J, Rudnichi A, Safar ME. Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study. J Hum Hypertens 2002;16:705-10.
18. Klocke R, Cockcroft JR, Taylor GJ, Hall IR, Blake DR. Arterial stiffness and central blood pressure, as determined by pulse wave analysis, in rheumatoid arthritis. Ann Rheum Dis 2003;62:414-8.
19. Wong M, Toh L, Wilson A, Rowley K, Karschimkus C, Prior D et al. Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation. Arthritis Rheum 2003;48 (1):81-9.
20. Selzer F, Sutton-Tyrrell K, Fitzgerald S, Tracy R, Kuller L, Manzi S. Vascular stiffness in women with systemic lupus erythematosus. Hypertension 2001;37:1075-82.
21. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003;107:499-511.
22. Torzewski J, Torzewski M, Bowyer DE, Frohlich M, Koenig W, Waltenberger J et al. C-reactive protein frequently colocalizes with the terminal complement complex in the intima of early atherosclerotic lesions of human coronary arteries. Arterioscler Thromb Vasc Biol 1998;18 (9):1386-92.
23. Coppack SW. Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 2001;60:349-56.
24. Fried SK, Bunkin DA, Greenberg AS. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998;83:847-50.
25. Lemieux I, Pascot A, Prud'homme D, Almeras N, Bogaty P, Nadeau A et al. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 2001;21:961-7.
26. Danias PG, Tritos NA, Stuber M, Botnar RM, Kissinger KV, Manning WJ. Comparison of aortic elasticity determined by cardiovascular magnetic resonance imaging in obese versus lean adults. Am J Cardiol 2003;91:195-9.
27. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosder Thromb Vasc Biol 1999;19:972-8.
28. Vigili de Kreutzenberg S, Kiwanuka E, Tiengo A, Avogaro A. Visceral obesity is characterized by impaired nitric oxide-independent vasodilation. Eur Heart J 2003;24:1210-5.
29. Nigam A, Mitchell GF, Lambert J, Tardif JC. Relation between conduit vessel stiffness (assessed by tonometry) and endothelial function (assessed by flow-mediated dilatation) in patients with and without coronary heart disease. Am J Cardiol 2003;15 (92):395-9.