Inhibitory effect on LPS-induced retinal microglial activation of downregulation of t-pa expression by siRNA interference

Current Eye Research

Volumn 34, Issue 6, 2009, Pages 476-484

  Wang, Wen Ying ^a,c   Xu, Ge Zhi ^a   Tian, Jie ^a   Sprecher, Alicia J ^b  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c QINGDAO UNIVERSITY   (China)

Author keywords

Activation; Cell culture; Microglia; Retina; Tissue plasminogen activator

Indexed keywords

INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CLINICAL EVALUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; LENTIVIRINAE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; LIPOPOLYSACCHARIDES; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; RETINAL NEURONS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TISSUE PLASMINOGEN ACTIVATOR; TRANSFECTION;

EID: 70350675559     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680902916108     Document Type: Article

References (26)

1. Ni Y-Q, Xu G-Z Xu,HuW-Z, Shi L,Qin Y-W, Da C-D. Neuroprotective effects of naloxone against light-induced photoreceptor degeneration through inhibiting retinal microglial activation. Invest Ophthalmol Vis Sci. 2008;49:2589-2598
2. Rogove AD, Tsirka SE. Neurotoxic responses by microglia elicited by excitotoxic injury in the mouse hippocampus. Curr Biol. 1997;8:19-25
3. RogoveAD, Siao C, Keyt B, Strickland S, Tsirka SE.Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system. J Cell Sci. 1999;112:4007-4016
4. Siao CJ, Tsirka SE. Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II. J Neurosci. 2002;22:3352-3358
5. Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med. 1998;4:228-231
6. Nagai N, De Mol M, Lijnen HR, Carmeliet P, Collen D. Role of plasminogen system components in focal cerebral ischemic infarction: A gene targeting and gene transfer study in mice. Circulation 1999;9:2440-2444
7. Tsirka S, Gualandris A, Amaral D, Strickland S. Excitotoxin induced neuronal degeneration and seizure are mediated by tissue-type plasminogen activator. Nature 1995;377:340-344
8. Bahi A, Dreyer JL. Overexpression of plasminogen activators in the nucleus accumbens enhances cocaine-, amphetamine, and morphine-induced reward and behavioral sensitization. Genes, Brain, Behav. 2008;7:244-256
9. Bahi A, Boyer F, le Gumy C, Kafri T, Dreyer JL. In vivo gene delivery of urokinase-type plasminogen activator with regulatable lentivirus induces behavioural changes in chronic cocaine administration. Eur J Neurosci. 2004;20:3473-3488
10. Bahi A, Kusnecov A, Dreyer JL. The role of tissue-type plasminogen activator system in amphetamine-induced conditional place preference extinction and reinstatement. Neuropsychopharmacology 2008;33:2726-2734
11. Imai Y, Kohsaka S. Intracellular signaling in M-CSF-induced microglia activation: Role of Iba1. Glia 2002;40:164-174
12. Sindhu S, Wu GS, Rao NA. Retinal microglial activation and chemotaxis by docosahexaenoic acid hydroperoxide. Invest Ophthalmol Vis Sci. 2006;47:3656-3663
13. Collen D. The plasminogen (fibrinolytic) system. Thromb Haemost 1999;82:259-270
14. Tsirka S, Rogove A, Bugge T, Degen J, Strickland S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci. 1997;17:543-552
15. Chen Z-L, Strickland S. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 1997;91:917-925
16. Chao CC,Hu S, Peterson PK. Glia, cytokines, and neurotoxicity. Crit Rev Neurobiol. 1995;9:189-205
17. Gehrmann J, Matsumoto Y, Kreutzberg GW. Microglia: Intrinsic immuneffector cell of the brain. Brain Res Brain Res Rev. 1995;20:269-287
18. Zeiss CJ, Johnson EA. Proliferation of microglia, but not photoreceptors, in the outer nuclear layer of the rd-1 mouse. Invest Ophthalmol Vis Sci. 2004;45:971-976
19. Zeng HY, Zhu XA, Zhang C, Yang LP, Wu LM, Tso MO. Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice. Invest Ophthalmol Vis Sci. 2005;46:2992-2999
20. Wang AL, Yu AC, Lau LT, Lee C, Wu LM, Zhu X, Tso MO. Minocycline inhibits LPS-induced retinal microglia activation. Neurochem Int. 2005;47:152-158 (Pubitemid 40848704)
21. Kreutzberg G. Microglia: A sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318
22. Gualandris A, Jones T, Strickland S, Tsirka S. Membrane depolarization induces the Ca 2+-dependent release of tissue plasminogen activator. J Neurosci. 1996;16:2220-2225
23. Akiyama H, Ikeda K, Kondo H, McGeer P, McGeer E. Immunohistochemical study of type-1 plasminogen activator inhibitor(PAI-1) in brain. Soc Neurosci Abstr. 1995;21:741
24. Krueger SR, Ghisu GP, Cinelli P, Gschwend TP, Osterwalder T, Wolfer DP, Sonderegger P. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997;17:8984-8996
25. Seeds N, Basham M, Haffke S. Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene. Proc Natl Acad Sci USA 1999;96:14118-14123
26. Wu Y-P, Siao C-J, Lu W, Sung T-C, FrohmanM, Milev P, Bugge T, Degen J, Levine J, Margolis R, Tsirka S. The tPA/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. J Cell Biol. 2000;148:1295-1304