Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha

Immunopharmacology and Immunotoxicology

Volumn 31, Issue 3, 2009, Pages 459-467

  Cho, Min Chul ^a   Lee, Sojung ^a   Choi, Hee Sook ^a   Yang, Young ^b   Tae Hong, Jin ^c   Kim, Sun Jong ^a   Yoon, Do Young ^a  

^a Konkuk University   (South Korea)

^b Sookmyung Women's University   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Coactivator; ELISA; Ligand; Metabolic disorder; PPAR?

Indexed keywords

BEZAFIBRATE; BINDING PROTEIN; LINOLEIC ACID; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COACTIVATOR P300; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PIRINIXIC ACID; RECEPTOR ANTIBODY; RECOMBINANT PROTEIN; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DOMAIN;

DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEP G2 CELLS; HUMANS; LIGANDS; LINOLEIC ACID; PEROXISOME PROLIFERATORS; PPAR ALPHA; PROTEIN BINDING; PYRIMIDINES; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS;

EID: 70350674189     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970902785246     Document Type: Article

References (21)

1. Lock, E.A., Mitchell, A.M., Elcombe, C.R. Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu. Rev. Pharmacol. Toxicol. 1989, 29, 145-164.
2. Giguere, V. Orphan nuclear receptors: from gene to function. Endocrinol. Rev. 1999, 20, 689-725.
3. Issemann, I., Green, S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990, 347, 645-650.
4. Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., Wahli, W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell. 1992, 68, 879-887.
5. Werman, A., Hollenberg, A., Solanes, G., Bjorbaek, C., Vidal- Puig, A. J., Flier, J.S. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. J. Biol. Chem. 1997, 272, 20230-20235.
6. Steinmetz, A.C., Renaud, J. P., Moras, D. Binding of ligands and activation of transcription by nuclear receptors. Annu. Rev. Biophys. Biomol. Struct. 2001, 30, 329-359.
7. Cho, M.C., Lee, K., Paik, S.G., Yoon, D.Y. Peroxisome proliferators- activated receptor (PPAR) modulators and metabolic disorsders. PPAR Res. 2008, 2008, 679137.
8. Reddy, J.K., Hashimoto, T. Peroxisomal beta-oxidation and peroxisome proliferators-activated receptor alpha: An adaptive metabolic system. Annu. Rev. Nutr. 2001, 21, 193-230.
9. Chou, C.J., Haluzik, M., Gregory, C., Dietz, K.R., Vinson, C., Gavrilova, O., Reitman, M.L. Wy14,643, a peroxisome proliferators- activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J. Biol. Chem. 2002, 277, 24484-24489.
10. Vu-Dac, N., Chopin-Delnnoy, S., Gervois, P., Bonnelye, E., Martin, G., Fruchart, J.C., Laudet, V., Staels, B. The nuclear receptors peroxisome proliferators-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-1 expression by fibrates. J. Biol. Chem. 1998, 273, 25713-25720.
11. Knight, B.L., Patel, D.D., Humphreys, S.M., Wiggins, D., Gibbons, G.F. Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. J. Lipid. Res. 2003, 44, 2049-2058.
12. Zandbergen, F., Plutzky, J. PPARalpha in Atherosclerosis and inflammation. Biochem. Biophys Acta. 2007, 1771, 972-982.
13. Chinetti, G., Gbaguidi, F.G., Griglio, S., Mallat, Z., Antonucci, M., Poulain, P., Chapman, J., Fruchart, J.C., Tedgui, A., Najib- Fruchart, J., Staels, B. CLA-1/SR-B1 is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferators-activated receptors. Circulation 2000, 101, 2411-2417.
14. Dowell, P., Ishmael, J.E., Avram, D., Peterson, V.J., Nevrivy, D.J., Leid, M. p300 functions as a coavtivator for the peroxisome proliferators- activated receptor alpha. J. Biol. Chem. 1997, 272, 33435-33443.
15. Miao, B., Sun, S., Santomenna, L.D., Zhang, J.H., Young, P., Mukherjee, R. Ligand-induced coactivator recruitment to peroxisome proliferators-activated receptor alpha characterized by fluorescence resonance energy transfer. Methods Enzymol. 2002, 357, 180-188.
16. Cho, M.C., Yoon, H.E., Kang, J.W., Park, S.W., Yang, Y., Hong, J.T., Song, E.Y., Paik, S.G., Kim, S.H., Yoon, D.Y. A simple method to screen ligands of peroxisome proliferators-activated receptor delta. Eur. J. Pharm. Sci. 2006, 29, 355-360.
17. Mckenna, N.J., Lanz, R.B; O' Malley B.W. Nuclear receptor coactivators: Cellular and molecular biology. Endocr. Rev. 1999, 20, 321-344.
18. Lim, H.J., Moon, I., Han, K. Transcription cofactor exhibit differential preference toward peroxisome proliferators-activated receptors alpha and delta in uterine cells. Endocrinology. 2004, 145, 2886-2895.
19. Corton, J.C., Anderson, S.P., Stauber, A. Central role of perosixome proliferators-activated receptors in the actions of peroxisome proliferators. Annu. Rev. Pharmacol. Toxicol. 2000, 40, 491-518.
20. Fruchart, J.C. Novel peroxisome proliferators activated receptoralpha agonist. Am. J. Cardiol. 2007, 100, n41-46.
21. Lee, H.S., Cho, M.C., Baek, T.W., Choe, Y.K., Kim, J.W., Hong, J.T., Myung, P.K., Paik, S.G., Yoon, D.Y. Epitope analysis of PPARgamma monoclonal antibody Pgamma48.34A and its application for screening PPARgamma ligands. J. Immunol. Methods. 2005, 296, 125-134.