메뉴 건너뛰기




Volumn 31, Issue 8, 2009, Pages 765-772

Challenges of genomics and proteomics in nephrology genomics and proteomics in nephrology

Author keywords

Acute kidney injury; Biomarkers; Diabetic nephropathy; Genomics; Glomerulonephritis; Proteomics; Urinary proteome

Indexed keywords

ACUTE KIDNEY FAILURE; CELL FUNCTION; CHRONIC KIDNEY DISEASE; DISEASE SEVERITY; GENE ACTIVITY; GENE EXPRESSION; GENOMICS; HUMAN; KIDNEY CLEARANCE; KIDNEY INJURY; MORBIDITY; MORTALITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEOMICS; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; UREMIA;

EID: 70350668664     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/08860220903100713     Document Type: Review
Times cited : (12)

References (53)
  • 1
    • 34447527541 scopus 로고    scopus 로고
    • Clinical proteomics-on the long way from bench to bedside
    • Mueller GA, Mueller CA, Dihazi H. Clinical proteomics-on the long way from bench to bedside. Nephrol Dial Transplant. 2007;22:1297-1300.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 1297-1300
    • Mueller, G.A.1    Mueller, C.A.2    Dihazi, H.3
  • 2
    • 34250169808 scopus 로고    scopus 로고
    • Genomics and proteomics in process development: Opportunities and challenges
    • Gupta P, Lee KH. Genomics and proteomics in process development: Opportunities and challenges. Trends Biotechnol. 2007;25:324-330.
    • (2007) Trends Biotechnol , vol.25 , pp. 324-330
    • Gupta, P.1    Lee, K.H.2
  • 5
    • 0034659898 scopus 로고    scopus 로고
    • Genomics, gene expression and DNA arrays
    • Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature. 2000;405:827-836.
    • (2000) Nature , vol.405 , pp. 827-836
    • Lockhart, D.J.1    Winzeler, E.A.2
  • 6
    • 39649124023 scopus 로고    scopus 로고
    • Array-based DNA diagnostics: Let the revolution begin
    • Beaudet AL, Belmont JW. Array-based DNA diagnostics: Let the revolution begin. Annu Rev Med. 2008;59:113-129.
    • (2008) Annu Rev Med , vol.59 , pp. 113-129
    • Beaudet, A.L.1    Belmont, J.W.2
  • 8
    • 0036707893 scopus 로고    scopus 로고
    • Genetics and pathogenesis of polycystic kidney disease
    • Ritz E. Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol. 2002;13:2384-2398.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2384-2398
    • Ritz, E.1
  • 9
    • 0031055335 scopus 로고    scopus 로고
    • Molecular genetic identification of families with juvenile nephronophthisis type 1: Rate of progression to renal failure
    • Hildebrandt F, Strahm B, Nothwang HG, Gretz N, Schnieders B, Singh-Sawhney I, et al. Molecular genetic identification of families with juvenile nephronophthisis type 1: Rate of progression to renal failure. Kidney Int. 1997;51:261-269.
    • (1997) Kidney Int , vol.51 , pp. 261-269
    • Hildebrandt, F.1    Strahm, B.2    Nothwang, H.G.3    Gretz, N.4    Schnieders, B.5    Singh-Sawhney, I.6
  • 10
    • 70349484209 scopus 로고    scopus 로고
    • Genetic variation in the transforming growth factor-b1.gene is associated with susceptibility to IgA nephropathy
    • Doi:10.1093/ndt/gfp079
    • Vuong MT, Lundberg S, Gunnarsson I, Wramner L, Seddighzadeh M, Hahn-Zoric M, et al. Genetic variation in the transforming growth factor-b1.gene is associated with susceptibility to IgA nephropathy. Nephrol Dial Transplant. 2009, doi:10.1093/ndt/gfp079.
    • (2009) Nephrol Dial Transplant
    • Vuong, M.T.1    Lundberg, S.2    Gunnarsson, I.3    Wramner, L.4    Seddighzadeh, M.5    Hahn-Zoric, M.6
  • 11
    • 62449129906 scopus 로고    scopus 로고
    • Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients
    • Yoon HJ, Chin HJ, Na KY, Chae DW, Kim S, Jeon US, et al. Association of angiotensin II type 2 receptor gene A1818T polymorphism with progression of immunoglobulin a nephropathy in Korean patients. J Korean Med Sci. 2009; 24(Suppl. 1):s38-s43.
    • (2009) J Korean Med Sci , vol.24 , Issue.SUPPL. 1
    • Yoon, H.J.1    Chin, H.J.2    Na, K.Y.3    Chae, D.W.4    Kim, S.5    Jeon, U.S.6
  • 12
    • 62449084818 scopus 로고    scopus 로고
    • The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality
    • Chin HJ, Cho HJ, Lee TW, Na KY, Yoon HJ, Chae DW, et al. The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality. J Korean Med Sci. 2009;24 (Suppl. 1):s30-s37.
    • (2009) J Korean Med Sci , vol.24 , Issue.SUPPL. 1
    • Chin, H.J.1    Cho, H.J.2    Lee, T.W.3    Na, K.Y.4    Yoon, H.J.5    Chae, D.W.6
  • 13
    • 0035199469 scopus 로고    scopus 로고
    • Prevalence, genetics, and clinical features of patients carrying podocin mutations in steroid-resistant nonfamilial focal segmental glomerulosclerosis
    • Caridi G, Bertelli R, Carrea A, Diduca M, Catarsi P, Artero M, et al. Prevalence, genetics, and clinical features of patients carrying podocin mutations in steroid-resistant nonfamilial focal segmental glomerulosclerosis. J Am Soc Nephrol. 2001;12:2742-2746.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 2742-2746
    • Caridi, G.1    Bertelli, R.2    Carrea, A.3    Diduca, M.4    Catarsi, P.5    Artero, M.6
  • 14
    • 66649089156 scopus 로고    scopus 로고
    • Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes mellitus
    • Pezzolesi MG, Poznik GD, Mychaleckyj JC, Paterson AD, Barati MT, Klein JB, et al. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes mellitus. Diabetes. 2009;58:1403-1410.
    • (2009) Diabetes , vol.58 , pp. 1403-1410
    • Pezzolesi, M.G.1    Poznik, G.D.2    Mychaleckyj, J.C.3    Paterson, A.D.4    Barati, M.T.5    Klein, J.B.6
  • 15
    • 0242669254 scopus 로고    scopus 로고
    • Differential gene expression following early renal ischemia-reperfusion
    • Supavekin S, Zhang W, Kucherlapati R, et al. Differential gene expression following early renal ischemia-reperfusion. Kidney Int. 2003;63:1714-1724.
    • (2003) Kidney Int , vol.63 , pp. 1714-1724
    • Supavekin, S.1    Zhang, W.2    Kucherlapati, R.3
  • 16
    • 26444434342 scopus 로고    scopus 로고
    • Pharmacologic manipulation of cell death: Clinical applications insight?
    • Green DR, Kroemer G. Pharmacologic manipulation of cell death: Clinical applications insight? J Clin Invest. 2005;115: 2610-2617.
    • (2005) J Clin Invest , vol.115 , pp. 2610-2617
    • Green, D.R.1    Kroemer, G.2
  • 17
    • 33846878502 scopus 로고    scopus 로고
    • Genomics of renal cell cancer: The biology behind and the therapy ahead
    • Jones J, Libermann TA. Genomics of renal cell cancer: The biology behind and the therapy ahead. Clin Cancer Res. 2007;13(Suppl. 2):s685-s692.
    • (2007) Clin Cancer Res , vol.13 , Issue.SUPPL. 2
    • Jones, J.1    Libermann, T.A.2
  • 18
    • 33645972282 scopus 로고    scopus 로고
    • Genomics of renal cell cancer-does it provide breakthrough?
    • Kopper L, Timar J. Genomics of renal cell cancer-does it provide breakthrough? Pathol Oncol Res. 2006;12:5-11.
    • (2006) Pathol Oncol Res , vol.12 , pp. 5-11
    • Kopper, L.1    Timar, J.2
  • 19
    • 0034757770 scopus 로고    scopus 로고
    • Proteomics: The move to mixtures
    • Peng J, Gygi SP. Proteomics: The move to mixtures. J Mass Spect. 2001;36:1083-1091.
    • (2001) J Mass Spect , vol.36 , pp. 1083-1091
    • Peng, J.1    Gygi, S.P.2
  • 20
    • 4043094133 scopus 로고    scopus 로고
    • Proteomics in nephrology: Current status and future directions
    • Thongboonkerd V. Proteomics in nephrology: Current status and future directions. Am J Nephrol. 2004;24:360-378.
    • (2004) Am J Nephrol , vol.24 , pp. 360-378
    • Thongboonkerd, V.1
  • 21
    • 0036236142 scopus 로고    scopus 로고
    • Proteomics and the kidney
    • Knepper MA. Proteomics and the kidney. J Am Soc Nephrol. 2002;13:1398-1408.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1398-1408
    • Knepper, M.A.1
  • 23
    • 33846930076 scopus 로고    scopus 로고
    • Urinary proteomics: A tool to discover biomarkers of kidney diseases
    • Dihazi H, Mueller GA. Urinary proteomics: A tool to discover biomarkers of kidney diseases. Proteomics. 2007;4: 39-50.
    • (2007) Proteomics , vol.4 , pp. 39-50
    • Dihazi, H.1    Mueller, G.A.2
  • 26
    • 31544463826 scopus 로고    scopus 로고
    • Proteomic patterns and prediction of glomerulosclerosis and its mechanisms
    • Xu BJ, Shyr Y, Liang X, Ma LJ, Donnert EM, Roberts JD, et al. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J Am Soc Nephrol. 2005;16: 2967-2975.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2967-2975
    • Xu, B.J.1    Shyr, Y.2    Liang, X.3    Ma, L.J.4    Donnert, E.M.5    Roberts, J.D.6
  • 27
    • 33645993265 scopus 로고    scopus 로고
    • Global survey of organ and organelle protein expression in mouse: Combined proteomic and transcriptomic profiling
    • Kislinger T, Cox B, Kannan A, Chung C, Hu P, Ignatchenko A, et al. Global survey of organ and organelle protein expression in mouse: Combined proteomic and transcriptomic profiling. Cell. 2006;125:173-186.
    • (2006) Cell , vol.125 , pp. 173-186
    • Kislinger, T.1    Cox, B.2    Kannan, A.3    Chung, C.4    Hu, P.5    Ignatchenko, A.6
  • 28
    • 4043077878 scopus 로고    scopus 로고
    • Proteome database of normal human glomerulus: Two-dimensional electrophoresis profiling and constructing of XML-based database
    • Yoshida Y, Miyazaki K, Kamijo K, Tsugita A, Kamiie J, Xu B, et al. Proteome database of normal human glomerulus: Two-dimensional electrophoresis profiling and constructing of XML-based database. J Am Soc Nephrol. 2003; 14(Suppl.):283A.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.SUPPL.
    • Yoshida, Y.1    Miyazaki, K.2    Kamijo, K.3    Tsugita, A.4    Kamiie, J.5    Xu, B.6
  • 29
    • 27844532498 scopus 로고    scopus 로고
    • Towards the application of proteomics in renal disease diagnosis
    • Vidal BC, Bonventre JV, Hong SI. Towards the application of proteomics in renal disease diagnosis. Clin Science. 2005;109:421-430.
    • (2005) Clin Science , vol.109 , pp. 421-430
    • Vidal, B.C.1    Bonventre, J.V.2    Hong, S.I.3
  • 30
    • 33645747471 scopus 로고    scopus 로고
    • Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis
    • Decramer S, Wittke S, Mischak H, et al. Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat Met. 2006;12:398-400.
    • (2006) Nat Met , vol.12 , pp. 398-400
    • Decramer, S.1    Wittke, S.2    Mischak, H.3
  • 31
    • 0346101481 scopus 로고    scopus 로고
    • Urine protein profiling with surface-enhanced laser-desorption/ionization time-offlight mass spectrometry
    • Schaub S, Wilkins J, Weiler T, et al. Urine protein profiling with surface-enhanced laser-desorption/ionization time-offlight mass spectrometry. Kidney Int. 2004;65:323-332.
    • (2004) Kidney Int , vol.65 , pp. 323-332
    • Schaub, S.1    Wilkins, J.2    Weiler, T.3
  • 32
    • 0036379687 scopus 로고    scopus 로고
    • Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation
    • Thongboonkerd V, McLeish KR, Arthur JM, Klein JB. Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation. Kidney Int. 2002;62:1461-1469.
    • (2002) Kidney Int , vol.62 , pp. 1461-1469
    • Thongboonkerd, V.1    McLeish, K.R.2    Arthur, J.M.3    Klein, J.B.4
  • 33
    • 11144356366 scopus 로고    scopus 로고
    • Characterization of the human urinary proteome: A method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots
    • Pieper R, Gatlin CL, McGrath AM, Makusky AJ, Mondal M, Seonarain M, et al. Characterization of the human urinary proteome: A method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics. 2004;4:1159-1174.
    • (2004) Proteomics , vol.4 , pp. 1159-1174
    • Pieper, R.1    Gatlin, C.L.2    McGrath, A.M.3    Makusky, A.J.4    Mondal, M.5    Seonarain, M.6
  • 34
    • 29544433936 scopus 로고    scopus 로고
    • Human urine proteome analysis by three separation approaches
    • Sun W, Li F, Wu S, Wang X, Zheng D, Wang J, Gao Y. Human urine proteome analysis by three separation approaches. Proteomics. 2005;5:4994-5001.
    • (2005) Proteomics , vol.5 , pp. 4994-5001
    • Sun, W.1    Li, F.2    Wu, S.3    Wang, X.4    Zheng, D.5    Wang, J.6    Gao, Y.7
  • 36
    • 33750364830 scopus 로고    scopus 로고
    • The human urinary proteome contains more than 1500 proteins including a large proportion of membranes proteins
    • Adachi J, Kumar C, Zhang Y, Olsen JV, Mann M. The human urinary proteome contains more than 1500 proteins including a large proportion of membranes proteins. Genome Biol. 2006;7:R80.
    • (2006) Genome Biol , vol.7
    • Adachi, J.1    Kumar, C.2    Zhang, Y.3    Olsen, J.V.4    Mann, M.5
  • 37
    • 3042570252 scopus 로고    scopus 로고
    • Discovery of protein biomarkers for renal diseases
    • Hewitt SM, Dear J, Star RA. Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol. 2004;15: 1677-1689.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1677-1689
    • Hewitt, S.M.1    Dear, J.2    Star, R.A.3
  • 38
    • 33750603834 scopus 로고    scopus 로고
    • Exosomal fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury
    • Zhou H, Pisitkun T, Aponte A, Yuen PS, Hoffert JD, Yasuda H, et al. Exosomal fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury. Kidney Int. 2006;70:1847-1857.
    • (2006) Kidney Int , vol.70 , pp. 1847-1857
    • Zhou, H.1    Pisitkun, T.2    Aponte, A.3    Yuen, P.S.4    Hoffert, J.D.5    Yasuda, H.6
  • 40
    • 32944479783 scopus 로고    scopus 로고
    • Establishment of a 2-D human urinary proteomic map in IgA nephropathy
    • Park MR, Wang EH, Jin DC, Cha JH, Lee KH, Yang CW, et al. Establishment of a 2-D human urinary proteomic map in IgA nephropathy. Proteomics. 2006;6:1066-1076.
    • (2006) Proteomics , vol.6 , pp. 1066-1076
    • Park, M.R.1    Wang, E.H.2    Jin, D.C.3    Cha, J.H.4    Lee, K.H.5    Yang, C.W.6
  • 41
    • 43549099362 scopus 로고    scopus 로고
    • Urinary proteome and potential biomarkers associated with serial pathogenesis steps of focal segmental glomerulosclerosis
    • Shui HA, Huang TZ, Ka SM, Chen PH, Lin YF, Chen A. Urinary proteome and potential biomarkers associated with serial pathogenesis steps of focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2008;23:176-185.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 176-185
    • Shui, H.A.1    Huang, T.Z.2    Ka, S.M.3    Chen, P.H.4    Lin, Y.F.5    Chen, A.6
  • 42
    • 23044462246 scopus 로고    scopus 로고
    • Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy
    • Haubitz M, Wittke S, Weissinger EM, Walden M, Rupprecht HD, Floege J, et al. Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy. Kidney Int. 2005;67:2313-2320.
    • (2005) Kidney Int , vol.67 , pp. 2313-2320
    • Haubitz, M.1    Wittke, S.2    Weissinger, E.M.3    Walden, M.4    Rupprecht, H.D.5    Floege, J.6
  • 43
    • 2442670130 scopus 로고    scopus 로고
    • Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes
    • Weissinger EM, Wittke S, Kaiser T, Haller H, Bartel S, Krebs R, et al. Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Kidney Int. 2004;65:2426-2434.
    • (2004) Kidney Int , vol.65 , pp. 2426-2434
    • Weissinger, E.M.1    Wittke, S.2    Kaiser, T.3    Haller, H.4    Bartel, S.5    Krebs, R.6
  • 44
    • 22044440445 scopus 로고    scopus 로고
    • Two-dimensional fluorescence difference gel electrophoresis analysis of the urine proteome in human diabetic nephropathy
    • Sharma K, Lee S, Han S, Lee S, Francos B, McCue P, et al. Two-dimensional fluorescence difference gel electrophoresis analysis of the urine proteome in human diabetic nephropathy. Proteomics. 2005;5:2648-2655.
    • (2005) Proteomics , vol.5 , pp. 2648-2655
    • Sharma, K.1    Lee, S.2    Han, S.3    Lee, S.4    Francos, B.5    McCue, P.6
  • 45
    • 34548363484 scopus 로고    scopus 로고
    • Characterization of diabetic nephropathy by urinary proteomic analysis: Identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients
    • Dihazi H, Mueller GA, Lindner S, Meyer M, Asif AR, Oellerich M, Strutz F. Characterization of diabetic nephropathy by urinary proteomic analysis: Identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients. Clin Chem. 2007;53:1636-1645.
    • (2007) Clin Chem , vol.53 , pp. 1636-1645
    • Dihazi, H.1    Mueller, G.A.2    Lindner, S.3    Meyer, M.4    Asif, A.R.5    Oellerich, M.6    Strutz, F.7
  • 46
    • 28044460957 scopus 로고    scopus 로고
    • Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients
    • Wittke S, Haubitz M, Walden M, Rohde F, Schwarz A, Mengel M, et al. Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients. Am J Transplant. 2005;5:2479-2488.
    • (2005) Am J Transplant , vol.5 , pp. 2479-2488
    • Wittke, S.1    Haubitz, M.2    Walden, M.3    Rohde, F.4    Schwarz, A.5    Mengel, M.6
  • 48
    • 48949093788 scopus 로고    scopus 로고
    • Exploring the uremic toxins using proteomic technologies
    • Schiffer E, Mischak H, Vanholder RC. Exploring the uremic toxins using proteomic technologies. Contrib Nephrol. 2008; 160:159-171.
    • (2008) Contrib Nephrol , vol.160 , pp. 159-171
    • Schiffer, E.1    Mischak, H.2    Vanholder, R.C.3
  • 49
    • 0035490569 scopus 로고    scopus 로고
    • Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase
    • Sarto C, Deon C, Doro G, Hochstrasser DF, Mocarelli P, Sanchez JC. Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase. Proteomics. 2001;1:1288-1294.
    • (2001) Proteomics , vol.1 , pp. 1288-1294
    • Sarto, C.1    Deon, C.2    Doro, G.3    Hochstrasser, D.F.4    Mocarelli, P.5    Sanchez, J.C.6
  • 51
    • 33644843348 scopus 로고    scopus 로고
    • Cytokeratin-20 and seminal vesicle secretory protein VI as possible marker proteins in urinary bladder preneoplastic lesions induced by N-butyl-N-(4-hydroxybutyl) nitrosamine
    • Kim HJ, Sohng I, Hwang CH, Park JY. Cytokeratin-20 and seminal vesicle secretory protein VI as possible marker proteins in urinary bladder preneoplastic lesions induced by N-butyl-N-(4-hydroxybutyl) nitrosamine. Int J Urol. 2006; 13(2):142-147.
    • (2006) Int J Urol , vol.13 , Issue.2 , pp. 142-147
    • Kim, H.J.1    Sohng, I.2    Hwang, C.H.3    Park, J.Y.4
  • 52
    • 32144462497 scopus 로고    scopus 로고
    • Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis
    • Tolson JP, Flad T, Gnau V, Dihazi H, Hennenlotter J, Beck A, et al. Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis. Proteomics. 2006;6: 697-708.
    • (2006) Proteomics , vol.6 , pp. 697-708
    • Tolson, J.P.1    Flad, T.2    Gnau, V.3    Dihazi, H.4    Hennenlotter, J.5    Beck, A.6
  • 53
    • 0030008236 scopus 로고    scopus 로고
    • Towards a comprehensive database of proteins from the urine of patients with bladder cancer
    • Rasmussen HH, Orntoft TF, Wolf H, Celis JE. Towards a comprehensive database of proteins from the urine of patients with bladder cancer. J Urol. 1996;155:2113-2119.
    • (1996) J Urol , vol.155 , pp. 2113-2119
    • Rasmussen, H.H.1    Orntoft, T.F.2    Wolf, H.3    Celis, J.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.