Preparation and evaluation of gel formulations for oral sustained delivery to dysphagic patients

Drug Development and Industrial Pharmacy

Volumn 35, Issue 7, 2009, Pages 780-787

  Miyazaki, Shozo ^a   Takahashi, Akie ^a   Itoh, Kunihiko ^a   Ishitani, Mariko ^a   Dairaku, Masatake ^b   Togashi, Mitsuo ^b   Mikami, Ryozo ^b   Attwood, David ^c  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b Teikoku Medix Co Ltd   (Japan)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Controlled release; Dysphagia; Gels; Oral drug delivery; Paracetamol

Indexed keywords

AGAR; GELATIN; GELLAN; GLUCAN; KAZEPITAN; PARACETAMOL; PECTIN; UNCLASSIFIED DRUG; XYLOGLUCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; DYSPHAGIA; ENVIRONMENT; FLOW KINETICS; GEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; STOMACH; STRENGTH; SUSTAINED DRUG RELEASE; SWALLOWING;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DEGLUTITION DISORDERS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; GELS; MALE; RATS; RATS, WISTAR; SWINE;

EID: 70350641506     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040802592443     Document Type: Article

References (30)

1. Hanya M, Itoh Y, Hiraiwa H, Arakawa T, Inagaki K, Okamoto Y, et al. (1997). An in vitro study on the release of caffeine from an agar-jelly preparation for a patient with tremors. Jpn J Hosp Pharm, 23:375-380
2. Kaneuchi M, Kohri N, Senbongi K, Sakai H, Iseki K. (2005). Preparing and evaluation of oral dosage form of ketamine considering simplicity for preparation in hospital and ease for patients to take. 1. Preparations using agar. Yakugaku Zasshi, 125:187-196
3. Hanawa T, Watanabe A, Hidaka M, Sugihara M, Watanabe M, Rikihisa T. (1996). New oral dosage form for elderly patients. Preparation and characterization of gelatin gel containing indigestible dextrin. Jpn J Hosp Pharm, 22:433-443
4. Hanawa T, Nakazawa M, Mohri K, Ito A, Tsuchiya T, Suzuki M, et al. (2000). Development of patient-friendly preparations: Preparation and characterization of allopurinol gelatin gel containing polyethylene oxide. J Pharm Sci Technol., (Jpn), 60:175-182
5. Hanawa T, Kasai I, Mohri K, Ito A, Tsuchiya T, Hanawa K, et al. (2000). Development of patient-friendly preparations III; preparation and characterization of carrageenan gel containing polyethylene oxide. Yakugaku Zasshi, 120:1209-1216
6. Endo H, Watanabe Y, Matsumoto M, Shirotake S. (2000). Preparation and evaluation of heat-sensitive melting gel-acetaminophen gel. Jpn J Hosp Pharm, 26:250-258
7. Watanabe A, Sugihara M. (1992). New dosage form for the elderly using sodium caseinate treated with moist heat in the form of saturated steam under pressure. Yakuzaigaku, 52:69-78.
8. Watanabe A, Hanawa T, Sugihara M, Yamamoto K. (1995). Development and pharmaceutical properties of a new oral dosage form of theophylline using sodium caseinate for possible use in elderly patients. Int J Pharm, 117:23-30.
9. Watanabe A, Hanawa M, Sugihara M. (1994). Application of glycerogelatin as oral dosage form for the elderly. J Pharm Sci Technol., (Jpn), 54:77-87.
10. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. (1995). New oral dosage form for elderly patients: Preparation and characterization of silk fibroin gel. Chem Pharm Bull, 43:284-288
11. Hanawa T, Watanabe A, Tsuchiya T, Ikoma R, Hidaka M, Sugihara M. (1995). New oral dosage form for elderly patients. II. Release behaviour of benfotiamine from silk fibroin gel. Chem Pharm Bull, 43:872-876
12. Hanawa T, Maeda R, Muramatsu E, Suzuki M, Sugihara M, Nakajima M. (2000). New oral dosage form for elderly patients. III. Stability of trichlormethiazide in silk fibroin gel and various sugar solutions. Drug Dev Ind Pharm, 26:1091-1097
13. Kubo W, Miyazaki S, Attwood D. (2003). Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations. Int J Pharm, 258:55-64. (Pubitemid 36712870)
14. Miyazaki S, Aoyama H, Kawasaki N, Kubo W, Attwood D. (1999). In situ gelling gellan formulations as vehicles for oral delivery. J Control Release, 60:287-295
15. Miyazaki S, Kawasaki N, Kubo W, Endo K, Attwood D. (2001). Comparison of in situ gelling formulations for the oral delivery of cimetidine. Int J Pharm, 220:161-168
16. Kubo W, Miyazaki S, Dairaku M, Togashi M, Mikami R, Attwood D. (2004). Oral sustained delivery of ambroxol from in situ-gelling pectin formulations. Int J Pharm, 271:233-240 (Pubitemid 38210101)
17. Kubo W, Konno Y, Miyazaki S, Attwood D. (2004). In situ gelling pectin formulations for oral sustained delivery of paracetamol. Drug Dev Ind Pharm, 30:593-599 (Pubitemid 38924629)
18. Kubo W, Itoh K, Miyazaki S, Attwood D. (2005). Oral sustained delivery of theophylline and cimetidine from in situ gelling pectin formulations in rabbits. Drug Dev Ind Pharm, 318:19-25.
19. Miyazaki S, Kubo W, Itoh K, Konno Y, Fujiwara M, Dairaku M, et al. (2005). The effect of taste masking agents on in situ gelling pectin formulations for oral sustained delivery of paracetamol and ambroxol. Int J Pharm, 297:38-49. (Pubitemid 40720264)
20. Itoh K, Kubo W, Fujiwara M, Hirayama T, Miyazaki S, Dairaku M, et al. (2006). The influence of variation of gastric pH on the gelation and release characteristics of in situ gelling pectin formulations. Int J Pharm, 312:37-42.
21. Itoh K, Kubo W, Fujiwara M, Watanabe H, Miyazaki S, Attwood D. (2006). The influence of gastric acidity and taste masking agent on in situ gelling pectin formulations for oral sustained delivery of acetaminophen. Biol Pharm Bull, 29:343-347
22. Itoh K, Hirayama T, Takahashi A, Kubo W, Miyazaki S, Dairaku M, et al, (2007). In situ pectin formulations for oral drug delivery at high gastric pH. Int J Pharm, 335:90-96
23. Kawasaki N, Ohkura R, Miyazaki S, Uno Y, Sugimoto S, Attwood D. (1999). Thermally reversible xyloglucan gels as vehicles for oral drug delivery. Int J Pharm, 181:227-234 (Pubitemid 29229809)
24. Miyazaki S, Kawasaki N, Endo K, Attwood D. (2001). Oral sustained delivery of theophylline from thermally reversible xyloglucan gels in rabbits. J Pharm Pharmacol, 53:1185-1191
25. Miyazaki S, Endo K, Kawasaki N, Kubo W, Watanabe H, Attwood D. (2003). Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. Drug Dev Ind Pharm, 29:113-119 (Pubitemid 36292934)
26. Ameer B, Greenblatt DJ, Divoll M, Abernethy DR, Shargel L. (1981). High-performance liquid chromatographic determination of acetaminophen in plasma: Single dose pharmacokinetic studies. J Chromatogr, 226:4-230.
27. Sugihara M. (1996). Development and application of dosage forms for elderly patients. Pharmaceuticals Monthly, 38:1703-1706
28. McConnell EL, Basit AW, Murdan S. (2008). Measurement of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments. J Pharm Pharmacol, 60:63-70.
29. Yamaoka K, Tanigawa Y, Nakagawa T, Uno T. (1981). Pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn, 4:879-885
30. Dressman JB, Berardi RR, Dermentzoglou LC, Russell TL, Schmaltz SP, Barnett JL, et al. (1990). Upper gastrointestinal pH in young, healthy men and women. Pharm Res, 7:756-761