In situ gelling pectin formulations for oral drug delivery at high gastric pH

International Journal of Pharmaceutics

Volumn 335, Issue 1-2, 2007, Pages 90-96

  Itoh, Kunihiko ^a   Hirayama, Tomohiro ^a   Takahashi, Akie ^a   Kubo, Wataru ^a   Miyazaki, Shozo ^a   Dairaku, Masatake ^b   Togashi, Mitsuo ^b   Mikami, Ryozo ^b   Attwood, David ^c  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b Teikoku Medix Co Ltd   (Japan)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Ambroxol; Gastric acidity; In situ gelation; Oral drug delivery; Pectin gels; Sustained release

Indexed keywords

AMBROXOL; CALCIUM ION; GALACTURONIC ACID; PECTIN;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ESTERIFICATION; GEL; GELATION; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STOMACH CONTENT; STOMACH JUICE; STOMACH PH; SUSTAINED DRUG RELEASE;

ADMINISTRATION, ORAL; AMBROXOL; ANIMALS; CALCIUM CHLORIDE; CHEMISTRY, PHARMACEUTICAL; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; ESTERIFICATION; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; GELS; HYDROGEN-ION CONCENTRATION; MALE; MODELS, CHEMICAL; PECTINS; RABBITS; RHEOLOGY; SOLUBILITY; STOMACH; VISCOSITY;

EID: 33947576770     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.10.042     Document Type: Article

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