Bioavailability of a natural isomer mixture compared with synthetic all-trans β-carotene in human serum

American Journal of Clinical Nutrition

Volumn 63, Issue 5, 1996, Pages 729-734

  Ben Amotz, Ami ^a   Levy, Yishai ^b  

^a NATIONAL INSTITUTE OF OCEANOGRAPHY   (Israel)

^b NONE

Author keywords

Dunaliella bardawil; HPLC; Carotene; carotene isomers

Indexed keywords

ALGAE; DUNALIELLA BARDAWIL;

ANTIOXIDANT; BETA CAROTENE;

ADULT; ARTICLE; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG SCREENING; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; VITAMIN INTAKE;

ADULT; ALGAE, GREEN; ANTIOXIDANTS; BETA CAROTENE; BIOLOGICAL AVAILABILITY; CAROTENOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; ISOMERISM; MALE; VITAMIN A; VITAMIN E;

EID: 0029868579     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/63.5.729     Document Type: Article

References (36)

1. Ben-Amotz A, Avron M. The biotechnology of cultivating the halotolerant alga Dunaliella. Trends Biotechnol 1990;8:121-6.
2. Chandler LA, Schwartz SJ. HPLC separation of cis-trans carotene isomers in fresh and processed fruits and vegetables. J Food Sci 1987;52:669-72.
3. Ben-Amotz A, Lers A, Avron M. Stereoisomers of β-carotene and phytoene in the alga Dunaliella bardawil. Plant Physiol 1988;86: 1286-91.
4. Ben-Amotz A, Mokady S, Avron M. The β-carotene rich alga Dunaliella bardawil as a source of retinol in rat diet. Br J Nutr 1988;59: 443-9.
5. Zechmeister L. Cis-trans isomeric carotenoids, vitamin A and arylpolyenes. Vienna: Springer Verlag, 1962.
6. Ben-Amotz A, Mokady S, Edelstein S, Avron M. Bioavailability of natural isomer mixture as compared with synthetic all-trans β-carotene in rats and chicks. J Nutr 1989;119:1013-9.
7. Mokady S, Avron M, Ben-Amotz A. Accumulation in chick livers of 9-cis versus all-trans β-carotene. J Nutr 1990;120:889-92.
8. Levin G, Ben-Amotz A, Mokady S. Liver accumulation of soluble all-trans or 9-cis β-carotene in rats and chicks. Comp Biochem Physiol 1994;107A:203-7.
9. Stahl W, Schwartz W, Sundquist A, Sies H. Cis-trans isomers of lycopene and β-carotene in human serum and tissues. Arch Biochem Biophys 1992;294:173-7.
10. Stahl W, Schwartz W, Sies H. Human serum concentrations of all-trans β- and α-carotene but not 9-cis β-carotene increase upon ingestion of a natural isomer mixture obtained from Dunaliella salina (Betatene). J Nutr 1993;123:847-51.
11. Tamai H, Murata T, Morinobu T, et al. Bioavailability of β-carotene in a carotenoid preparation derived from Dunaliella bardawil in human male adults. Vitamins (Japan) 1993;67:127-32.
12. Micozzi MS, Brown ED, Edwards DK, et al. Plasma carotenoid response to chronic intake of selected food and β-carotene supplements in men. Am J Clin Nutr 1992;55:1120-5.
13. Wang XD, Krinsky N, Benotti PN, Russell RM. Biosynthesis of 9-cis retinoic acid from 9-cis β-carotene in human intestinal mucosa in vitro. Arch Biochem Biophys 1994;313:150-5.
14. Jimenez C, Pick U. Differential reactivity of β-carotene isomers from Dunaliella bardawil toward oxygen radicals. Plant Physiol 1993;101: 381-90.
15. Levin G, Mokady S Antioxidant activity of 9-cis compared to all-trans β-carotene in vitro. Free Radic Biol Med 1994;17:77-82.
16. Bitterman N, Melamed Y, Ben-Amotz A. β-Carotene and CNS oxygen toxicity in rats. J Appl Physiol 1994;76:1073-6.
17. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330: 1029-35.
18. Greenberg ER, Baron JA, Tosteson TD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 1994;331:141-7.
19. Ziegler RG. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 1989;119:116-22.
20. Ziegler RG. Vegetables, fruits and carotenoids and the risk of cancer. Am J Clin Nutr 1991;53(suppl):251S-9S.
21. Shaish A, Avron M, Ben-Amotz A. Effect of irradiation on the formation of stereoisomers in the biosynthesis of β-carotene in Dunaliella bardawil. Plant Cell Physiol 1990;31:689-96.
22. Jorgensen K, Skibsted LH. Carotenoids scavenging of radicals. Z Lebensm Unters Forsch 1993;196:423-9.
23. Ben-Amotz A, Edelstein S, Avron M. Use of Dunaliella bardawil as a source of vitamin A. Br Poultry Sci 1986;27:613-9.
24. Jensen CD, Howes TW, Spiller GA, Pattison TS, Whittam JH, Scala J. Observations on the effects of ingesting cis and trans β-carotene isomers on human serum concentrations. Nutr Rep Int 1987;35:413-22.
25. Mokady S, Cogan U. Nutritional evaluation of a protein concentrate and of carotenes derived from Dunaliella bardawil. J Sci Food Agric 1988;42:249-54.
26. Lavy A, Ben-Amotz A, Aviram M. Preferential inhibition of LDL oxidation by all-trans isomer of β-carotene in comparison with 9-cis β-carotene. Eur J Clin Chem Clin Biochem 1993;31:83-90.
27. Bauernfeind JC, ed. Carotenoids as colorants and retinol precursors. New York: Academic Press, 1981.
28. Krinsky NI. Antioxidant functions of carotenoids. Free Radic Biol Med 1989;7:617-35.
29. Terao J. Antioxidant activity of β-carotene related carotenoids in solution. Lipids 1989;24:659-61.
30. Lin BP, Nagao A, Terao J, Tanaka K, Suzuki T, Takama K. Antioxidant activity of xanthophylls on peroxyl radical mediated phospholipid peroxidation. Biochim Biophys Acta 1992;1126:178-84.
31. Hughes GS, Ringer TV, Francon SF, Means LK, De Loof MJ. Lack of effect of beta-carotene on lipids and sex steroid hormones in hyperlipidemics. Am J Med Sci 1994;308:16-22.
32. Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA, Brookmeyer R. Serum beta-carotene, vitamin A and E, selenium and die risk of cancer. N Engl J Med 1988;315:1250-4.
33. Comstock GW, Menkes MS, Schober SE, Vuilleumier JP, Helsing KJ. Serum levels of retinol, beta-carotene and alpha-tocopherol in older adults. Am J Epidemiol 1988;127:114-23.
34. Wang XD, Krinsky NI, Benotti PN, Russell RM. Biosynthesis of 9-cis retinoic acid from 9-cis β-carotene in human intestinal mucosa in vitro. Arch Biochem Biophys 1994;313:150-5.
35. Nagano A, Olson JA. Enzymatic formation of 9-cis, 13-cis and all-trans retinols from isomers of β-carotene. FASEB J 1994;8:968-73.
36. Gaziano JM, Johnson EJ, Russell RM, et al. Discrimination in absorption or transport of β-carotene isomers after oral supplementation with either all-trans- or 9-cis β-carotene. Am J Clin Nutr 1995;61:1248-52.