Gas-phase Smiles rearrangement in structural analysis of a pseudo-oxidative impurity generated in the pharmaceutical synthesis of S-(thiobenzoyl)thioglycolic acid

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 3, 2010, Pages 577-582

  Wu, Lianming ^a   Zhou, Leon ^a   Vogt, Frederick G ^a   Liu, David Q ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Base catalyzed hydrolysis; DFT calculations; Gas phase Smiles rearrangement; Impurity characterization; Ipso nucleophilic substitution

Indexed keywords

(THIOBENZOYL)THIOGLYCOLIC ACID; BASE; THIOGLYCOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; CATALYSIS; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DEUTERIUM HYDROGEN EXCHANGE; DRUG IMPURITY; DRUG SYNTHESIS; GAS; HYDROLYSIS; MASS SPECTROMETRY; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

CHEMISTRY, PHARMACEUTICAL; DEUTERIUM EXCHANGE MEASUREMENT; DRUG CONTAMINATION; MASS SPECTROMETRY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIOGLYCOLATES;

EID: 70350613209     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.09.019     Document Type: Article

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