A JNK inhibitor SP600125 induces defective cytokinesis and enlargement in P19 embryonal carcinoma cells

Cell Biochemistry and Function

Volumn 27, Issue 7, 2009, Pages 468-472

  Nakaya, Kohei ^a   Ooishi, Ryo ^a   Funaba, Masayuki ^b   Murakami, Masaru ^a  

^a AZABU UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

c Jun NH2 terminal kinase; Cell size; Endoreduplication; P19; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; PROTEIN P21; RETINOIC ACID; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL ENLARGEMENT; CELL SIZE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; DNA CONTENT; EMBRYONAL CARCINOMA STEM CELL; ENDOREDUPLICATION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTHRACENES; CELL ENLARGEMENT; CELL PROLIFERATION; CELL SHAPE; CYTOKINESIS; DEMECOLCINE; EMBRYONAL CARCINOMA STEM CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; PROTEIN KINASE INHIBITORS;

EID: 70350584759     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1597     Document Type: Article

References (30)

1. Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 2007; 19: 142-149.
2. Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA. Defective T cell differentiation in the absence of Jnk1. Science 1998; 282: 2092-2095. (Pubitemid 29001267)
3. Yang DD, Conze D, Whitmarsh AJ, et al. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 1998; 9: 575-585. (Pubitemid 28499208)
4. Wang H, Ikeda S, Kanno S, et al. Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells. FEBS Lett 2001; 503: 91-96. (Pubitemid 32769962)
5. Amura CR, Marek L,Winn RA, Heasley LE. Inhibited neurogenesis in JNK1-deficient embryonic stem cells. Mol Cell Biol 2005; 25: 10791-10802.
6. McBurney MW. P19 embryonal carcinoma cells. Int J Dev Biol 1993; 37: 135-140.
7. Nakaya K, Murakami M, Funaba M. Regulatory expression of Brachyury and Goosecoid in P19 embryonal carcinoma cells. J Cell Biochem 2008; 105: 801-813.
8. Smith PK, Krohn RI, Hermanson GT, et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 150: 76-85.
9. Murakami M, Kondo S, Funaba M. Expression and function of alternative splice variants of the mouse TGF-β type I receptor. Cell Biol Int 2008; 32: 848-854.
10. Funaba M, Ikeda T, Murakami M, et al. Transcriptional activation of mouse mast cell protease-7 by activin and transforming growth factor-β is inhibited by microphthalmia-associated transcription factor. J Biol Chem 2003; 278: 52032-52041. (Pubitemid 38035788)
11. Heasley LE, Storey B, Fanger GR, et al. GTPase-deficient Gα16 and Gαq induce PC12 cell differentiation and persistent activation of cJun NH2-terminal kinases. Mol Cell Biol 1996; 16: 648-656. (Pubitemid 3021962)
12. Akiyama S, Yonezawa T, Kudo TA, et al. Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells. J Biol Chem 2004; 279: 36616-36620. (Pubitemid 39129006)
13. Bennett BL, Sasaki DT, Murray BW, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001; 98: 13681-13686.
14. Landberg G, Tan EM, Roos G. Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp Cell Res 1990; 187: 111-118. (Pubitemid 20069605)
15. 2-terminal kinase (JNK) activation in multiple myeloma cell lines. Oncogene 2003; 22: 8797-8801.
16. Du L, Lyle CS, Obey TB, et al. Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem 2004; 279: 11957-11966.
17. Jacobs-Helber SM, Sawyer ST. Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines. Blood 2004; 104: 696-703.
18. Mingo-Sion AM, Marietta PM, Koller E, Wolf DM, Van Den Berg CL. Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. Oncogene 2004; 23: 596-604.
19. Moon DO, Kim MO, Choi YH, Kim ND, Chang JH, Kim GY. Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cells. Cancer Lett 2008; 264: 316-325.
20. Miyamoto-Yamasaki Y, Yamasaki M, Tachibana H, Yamada K. Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Cell Biol Int 2007; 31: 1501-1506. (Pubitemid 47610738)
21. 2/M. Mol Cell Biol 1999; 19: 8469-8478.
22. Canman JC, Lewellyn L, Laband K, et al. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science 2008; 322: 1543-1546.
23. Miller AL, Bement WM. Regulation of cytokinesis by Rho GTPase flux. Nat Cell Biol 2009; 11: 71-77.
24. Lim L, Manser E, Leung T, Hall C. Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur J Biochem 1996; 242: 171-185. (Pubitemid 26414218)
25. Gaillard P, Jeanclaude-Etter I, Ardissone V, et al. Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J Med Chem 2005; 48: 4596-4607. (Pubitemid 40993420)
26. Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497-1501. (Pubitemid 28538613)
27. Chan TA, Hwang PM, Hermeking H, Kinzler KW, Vogelstein B. Cooperative effects of genes controlling the G2/M checkpoint. Genes Dev 2000; 14: 1584-1588. (Pubitemid 30460907)
28. Sugimoto-Shirasu K, Roberts K. "Big it up": endoreduplication and cell-size control in plants. Curr Opin Plant Biol 2003; 6: 544-553.
29. Lilly MA, Duronio RJ. New insights into cell cycle control from the Drosophila endocycle. Oncogene 2005; 24: 2765-2775. (Pubitemid 40638088)
30. Lee CH, Inoki K, Guan KL. mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol 2007; 47: 443-467.